Endothelin peptides

Current Opinion in Nephrology and Hypertension

Volumn 5, Issue 1, 1996, Pages 12-15

  Hirata, Yukio ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN ISOPEPTIDE; ENDOTHELIN PEPTIDE; ENDOTHELIN PEPTIDE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; CARDIOVASCULAR MALFORMATION; CONGENITAL MALFORMATION; CRANIOFACIAL MALFORMATION; HIRSCHSPRUNG DISEASE; MEGACOLON; MOUSE; NEURAL CREST; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0029932661     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199601000-00004     Document Type: Review

References (16)

1. Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R, Oda H, Kuwaki T, Cao W, Kamada N, Jishage K et al.: Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 1994, 368:707-710. This paper is the first report on ET-1 null mice by gene targeting, showing an unexpected phenotype with craniofacial abnormalities, indicating that ET-1 is essential for the development of craniopharyngeal tissues. An interesting observation is that heterozygous mice presented with hypertension rather than hypotension.
2. Kuriha Y, Kurihara H, Oda H, Maemura K, Nagai R, Ishikawa T, Yazaki Y: Aortic arch malformation and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest 1995, 96:293-300. ET-1 null mice presented with aortic arch malformation and ventricular septal defect, suggesting that ET-1 is important in the development of the cardiovascular system derived from the first branchial arch and endocardial cushion.
3. Harats D, Kurihara H, Belloni P, Oakley H, Zioben A, Ackley D, Cain G, Kurihara Y, Lawa R, Sigol E: Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter. J Clin Invest 1995, 95:1335-1344.
4. Télémaque S, Niranjan V, deWit O, Yanagisawa M: Adenovirus-mediated in vivo expression of human endothelin-1 cDNA in the rat [Abstract]. IV International Conference on Endothelin, London 1995. C15.
5. A knockout mice [Abstract]. IV International Conference on Endothelin, London 1995, C29.
6. Baynash AG, Hosoda K, Giaid A, Richardson JA, Emoto N, Hammer RE, Yanagisawa M: Interaction of endothelin-3 and endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 1994, 79:1277-1285. This paper is the first report on ET-3 null mice by gene targeting, showing an unexpected phenotype with megacolon and coat colour spotting. It is interesting that defects in the ET-3 gene may cause Hirschsprung's disease in humans.
7. B receptor.
8. B receptor is essential for the development of two neural crest-derived cell lineages (enteric ganglion neuron and epidermal melanocytes).
9. Romeo G, Ronchetto P, Luo Y, Barone V, Ceccherini I, Pasini P, Bocciardi R, Lerone M, Kaarlainen H, Martucciello G: Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschpsrung's disease. Nature 1994, 367:377-378.
10. Xu D, Emoto N, Giaid A, Slanghter C, Kaw S, deWit D, Yanagisawa M: ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 1994, 78:473-485. This paper describes the identification and characterization of ECE-1 from bovine adrenal glands. ECE-1 is a type II integral membrane-bound metalloprotease structurally homologous to neural endopeptidase 24,11 and Kell blood group protein. The proposed mechanism for its intracellular processing sites (Golgi complex and secretory vesicles), other than the plasma membrane, is intriguing.
11. Ikura T, Sawamura T, Shiraki T, Hosokawa H, Kido T, Hoshikawa H, Shimada K, Tanzawa K, Kobayashi S, Miwa S, Masaki T: cDNA cloning and expression of bovine endothelin converting enzyme. Biochem Biophys Res Commun 1994, 203:1417-1422.
12. Shimada K, Takahashi M, Tanzawa K: Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells. J Biol Chem 1994, 269:18275-18278. First cloning of ECE-1 from rat endothelial cells, revealing an identical enzyme isolated from bovine adrenal gland [9••].
13. Shimada K, Matsushima Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K: Cloning and functional expression of human endothelin-converting enzyme cDNA. Biochem Biophys Res Commun 1995, 207:807-812.
14. Yorimitsu K, Moroi K, Inagaki N, Saito T, Matsuda Y, Masaki T, Seino S, Kimura S: Cloning and sequence of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2. Biochem Biophys Res Commun 1995, 208:721-727.
15. Emoto N, Yanagisawa M: Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem 1995, 270:15262-15268.
16. Yanagisawa H, Makiba SD, deWit D, Emoto N, Yanagisawa M, Hammer RE: Knocking out ECE-1 and ECE-2 in mice [Abstract]. IV International Conference on Endothelin, London, 1995. p14.