Both total chain length and position of dimethyl-branching effect the myocardial uptake and retention of radioiodinated analogues of 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid (DMIPP)

Annals of Nuclear Medicine

Volumn 10, Issue 1, 1996, Pages 19-32

  Knapp Jr , F F ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

Cardiac SPECT; Cardiodine; DMIPP; Iodine 123; Methyl branched fatty acids

Indexed keywords

15 (4 IODOPHENYL) 3 METHYLPENTADECANOIC ACID I 123; DECANOIC ACID DERIVATIVE; IODINE 123;

ANIMAL EXPERIMENT; ARTICLE; DOG; FATTY ACID METABOLISM; HEART INFARCTION; HEART MUSCLE ISCHEMIA; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

ANIMALS; DOGS; ENERGY METABOLISM; FATTY ACIDS; FEMALE; HEART; IODINE RADIOISOTOPES; IODOBENZENES; MOLECULAR STRUCTURE; MYOCARDIUM; RATS; RATS, INBRED F344; TISSUE DISTRIBUTION;

EID: 0029932539     PISSN: 09147187     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03165050     Document Type: Article

References (8)

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2. Knapp FF Jr, Goodman MM. The design and biological properties of iodine-123-labeIed 3-methyl-branched fatty acids. In Proceedings of the Workshop on Radiolabeled Free Fatty acids, Academic Hospital Free University, Amsterdam, The Netherlands, July 6,1984;
3. Eur Heart J 6: 71-84, 1985.
4. Knapp FF Jr, Goodman MM, Ambrose KR, Som P, Brill AB, Yamamoto K, et al. The development of radioiodinated 3-methyl-branched fatty acids for evaluation of myocardial disease by single photon techniques. In Noninvasive Measurement of Cardiac Metabolism, EE van der Wall (ed.), Amsterdam, Martinus Nijhoff Publishers, pp. 159-202, 1987.
5. Knapp JR FF, Ambrose KR, Goodman MM. New radioiodinated methyl-branched fatty acids for cardiac imaging. Eur J Nucl Med 12: S539-544, 1986.
6. Knapp Jr FF, Kropp J. Iodine-123-labeled fatty acids for myocardial SPECT: Current status and future perspectives. Eur J Nucl Med, Invited Review, 22: 361-381, 1995.
7. Dudczak R, Schmoliner R, Angelberger P, Knapp FF Jr, Goodman MM. Structurally modified fatty acids: clinical potential as tracers of metabolism. Eur J Nucl Med 12: S45-S48, 1986.
8. Goodman MM, Callahan AP, Cunningham EB, Kirsch G, Knapp FF Jr. Synthesis and evaluation of radioiodinated terminal p-iodothienyl-substituted α- and β-methylbranched fatty acids: a new class of myocardial imaging agents. J Med Chem 27: 390-396, 1984.