Inhibition of CD4 cross-linking - Induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: Vesnarinone inhibits fas expression and apoptosis by blocking cytokine secretion

Blood

Volumn 87, Issue 6, 1996, Pages 2361-2368

  Oyaizu, Naoki ^a,b   Mc Closkey, Thomas W ^a   Than, Soe ^a   Pahwa, Savita ^a  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^b NSUH CUMC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; FAS ANTIGEN; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 2; INTERLEUKIN 4; PIPERANOMETOZINE; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; DRUG ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADJUVANTS, IMMUNOLOGIC; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; ANTIGENS, CD95; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; DEPRESSION, CHEMICAL; GENE EXPRESSION REGULATION; HIV SERONEGATIVITY; HUMANS; IMMUNOLOGIC CAPPING; LYMPHOKINES; QUINOLINES;

EID: 0029932280     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.6.2361.bloodjournal8762361     Document Type: Article

References (59)

1. Maruyama I, Maruyama Y, Nakajima T, Kitajima I, Osame M, Zhao J-Q, Chen ISY, Nakai S, Ikeda M, Yabu-uchi Y, Adachi M: Vesnarinone inhibits production of HIV-1 in cultured cells. Biochem Biophys Res Commun 195:1264, 1993
2. Busch FW, Tillmann A, Becker EW, Owsianowski M, Berg PA: The inhibitory effects of a positive quinolinone derivative, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinoline (OPC-8212), on bone-marrow progenitor cells and peripheral lymphocytes. Eur J Pharamacol 42:629, 1992
3. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 175:331, 1992
4. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keel RPM, Miedema F: Programmed cell death of T cells in HIV-1 infection. Science 257:217, 1992
5. Oyaizu N, McCloskey TW, Coronesi M, Chirmule N, Katyanaraman VS, Pahwa S: Accelerated apoptosis in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood 82:3392, 1993
6. + T cells from HIV-infected persons. J Immunol 153:412, 1994
7. Carbonari M, Cibati M, Cherchi M, Sbarigia D, Pesce AM, Dell' Anna L, Modica A, Fiorilli M: Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotheraphy by an novel flow immunocytometric method. Blood 83:1268, 1994
8. Patterson BK, Till M, Otto P, Goolsby C, Furtado MR, McBride LJ, Wolindky SM: Detection of HIV-1 DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry. Science 260:976, 1993
9. Saksela K, Stevens C, Rubinstein P, Baltimore D: Human immunodeficiency virus type 1 mRNA expression in peripheral blood cells predicts disease progression independently of the numbers of CD4+ lymphocytes Proc Natl Acad Sci USA 91:1104, 1994
10. Yonehara S, Ishii A, Yonehara M: A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J Exp Med 169:1747, 1989
11. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen fas can mediate apoptosis. Cell 66:233, 1991
12. Oyaizu N, McCloskey TW, Soe Than, Hu R, Kalyanaraman VS, Pahwa S: Crosslinking of CD4 molecules up-regulates Fas antigen expression in lymphocytes by inducing interferon γ and tumor necrosis factor-α secretion. Blood 84:2622, 1994
13. Lahdevirta J, Maury CPJ, Teppo A-M, Repo H: Elevated levels of circulating cahectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 85:289, 1988
14. Fuchs D, Hausen A, Reibnegger G, Werner ER, Werner-Felmayer G, Dierich MP, Wachter H: Interferon-γ concentration are increased in sera from individuals infected with human immunodeficiency virus type 1. J Acquire Immune Deitc Syndr 2:158, 1989
15. Emille D, Permutter M, Malliot MC, Crevon MC, Brousse N, Delfraissy JF, Dormont J, Galanaud P: Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes. J Clin Invest 86:148, 1990
16. Fan J, Bass HZ, Fahey JL: Elevated IFN-γ and decreased IL-2 gene expression are associated with HIV infection. J Immunol 151:5031, 1993
17. Graziosi C, Pantaleo G, Gantt KR, Fortin J-P, Demarest JF, Cohen OJ, Sekaly RP, Fauci AS: Lack of evidence for the dichotomy of Th1 and Th2 predominance in HIV-infected individuals. Science 265:248, 1994
18. Piatak M, Saag MS, Yang LC, Clark SJ, Kappes JC, Luk K-C, Hahn BH, Shaw GM, Lifson JD: High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259:1749, 1993
19. Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS: HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362:355, 1993
20. Embretson J, Zupancic M, Ribas JL, Burke A, Racz P, Tenner-Racz K, Haase AT: Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362:359, 1993
21. Hu R, Oyaizu N, Kalyanaraman VS, Pahwa S: HIV-1 gp160 as a modifier of TH1 and TH2 cytokine response: gp160 suppresses INF-γ and IL-2 production concomitantly with enhanced IL-4 production in vitro. J Immunol Immunopathol 73:245, 1994
22. Stohl W, Posnett DN, Chiorazzi N: Induction of T cell-dependent B cell differentiation by anti-CD3 monoclonal antbodies. J Immunol 138:1667, 1987
23. McCloskey TW, Oyaizu N, Pahwa S: Use of flow cytometric assay to quantitate apoptosis in human lymphocytes. Clin Immunol Immunopathol 71:14, 1994
24. Ehlers S, Smith KA: Differentiation of T cell lymphokine gene expression: The in vitro acquisition of T cell memory. Proc Natl Acad Sci USA 173:25, 1991
25. Yamamura M, Uemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modlin RL: Defining protective responses to pathogens: Cytokine profiles in leprosy lesions. Science 254:277, 1991
26. Landau NR, Warton M, Littman DR: The envelope glycoprotein of human immunodeficiency virus binds to the immunoglobulin-like domain of CD4 Nature 334:159, 1988
27. Clouse KA, Cosentino LM, Weih KA, Pyle SW, Robbins PB, Hochstein HD, Natarajan V, Farrar WL: The HIV-1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion. J Immunol 147:2892, 1991
28. Soe Than, Oyaizu N, Kalyanaraman VS, Pahwa S: Effect of HIV-1 envelope perotein gp160 on cytokine production from cord blood T cells. Blood 84:184, 1994
29. + T-cell clones. J Virol 65:6277, 1991
30. Wahl LM, Corcoran ML, Pyle SW, Arthur LO, Harel-Bellan A, Farrar WL: Human immunodeficiency virus glycoprotein (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1. Proc Natl Acad Sci USA 86:621, 1989
31. Borghi P, Fantuzzi L, Varano B, Gessani S, Puddu P, Conti L, Capobianchi MR, Ameglio F, Belardelli F: Induction of interleukin-10 by human immunodeficiency virus type 1 and its gp120 protein in human monocytes/macrophages. J Virol 69:1284, 1995
32. Liu Y, Janeway, Jr CA: Interferon γ plays a critical role in induced cell death of effector T cell: A possible third mechanism of self-tolerance. J Exp Med 172:1735, 1990
33. Groux H, Monte D, Plouvier B, Capon D, Ameisen J-C: CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells: respective roles of IL-1, IL-2, interferone-γ and accessory cells. Eur J Immunol 23:1623, 1993
34. Wong GHW, Goeddel DV: Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J Immunol 152:1751, 1994
35. Wang J, Stohlman SA, Dennert G: TCR cross-linking induces CTL death via internal action of TNF. J Immunol 152:3824, 1994
36. Clement M-V, Stamenkovic I: Fas and tumor nectrosis factor-mediated cell death: Similarities and distinction. J Exp Med 180:557, 1994
37. Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin K-M, Krammer PH: Sensitization of T cells to CD95-mediated apoptosis by HIV-1 tat and gp120. Nature 375:495, 1995
38. Dhein J, Walczac H, Baumler C, Debatin K-M, Krammer PH: Autocrine T-cell suicide mediated by APO-1 (Fas/CD95). Nature 373:438, 1995
39. Klas C, Debatin KM, Jonker RR, Krammer PH: Activation interferences with APO-1 pathway in mature human T cells. Int Immunol 5:625, 1993
40. Owen-Schaub LB, Yonehara S, CrumpIII WL, Grimm EA: DNA fragmentation and cell death is selectively triggerd in activated human lymphocytes by Fas antigen expression. Cell Immunol 140:197, 1992
41. Debatin K-M, Enenke-Stoogt S, Benner A, Krammer PH: High expression of Apo-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children. Blood 83:3101, 1994
42. McCloskey TW, Oyaizu N, Kaplan M, Pahwa S: Expression of the Fas antigen in patients infected with human immunodeficiency virus. Cytometry 22:111, 1995
43. Katsikis PD, Wunderlich ES, Smith CA, Hersenberg LA, Herzenberg LA: Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 181:2029, 1995
44. Itoh N, Nagata S: A novel protein domain required for apoptosis. Mutation analysis of human Fas antigen. J Biol Chem 268:10932, 1993
45. Gulbins E, Bissonnette R, Mahboubi A, Martins S, Nishioka W, Brunner T, Baier G, Baier-Bitterlich G, Byrd C, Lang F, Kolensnick R, Altman A, Green D: Fas-induced apoptosis is mediated via a ceramide-initiated Ras signaling pathway. Immunity 2:341, 1995
46. Kim K-Y, Linardic C, Obeid L, Hannun Y: Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon. J Biol Chem 266:484, 1991
47. Wang Z, Dudhane A, Orlikowsky T, Clarke K, Li X, Darzynkiewicz Z, Hoffmann MK: CD4 engagement induces Fas antigen-dependent apoptosis in vivo. Eur J Immunol 24:1549, 1994
48. Wang Z, Orlikowsky T, Dudhane R, Mittler R, Blum M, Lacy E, Riethmuller G, Hoffmann MK: Deletion of T lymphocytes in human CD4 transgenic mice induced by HIV-gp120 and gp120-specific antibodies from AIDS patients. Eur J Immunol 24:1553, 1994
49. Endoh M, Yanagisawa T, Taira N, Brinks JR: Effects of new motropic agents on cyclic nucleotide metabolism and calcium transients in canine venticular muscle. Circulation 73 (3 Pt2).III 117, 1986
50. Felman AM, Bristow MR, Parmley WW, Carson PE, Pepine CJ, Gilbert EM, Strobeck JE, Hendrix GH, Powers ER, Bain BP, White BG, for the Vesnarinone Study Group: Effects of vesnarinone on morbidity and mortality in patients with heart failure. N Engl J Med 329:149, 1993
51. Matsui S, Matsumoto A, Mataba Y, Uchida A, Sasayama S: Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone. J Clin Invest 94:1212, 1994
52. Renz H, Gong J-H, Schmidt A, Nain M, Gemsa D: Release of tumor necrosis factor-α from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides. J Immunol 141:2388, 1988
53. Severn A, Rapson NT, Hunter CA, Liew FY: Regulation of tumor necrosis factor production by adrenaline and β-adrenergic agonists. J Immunol 148:3441, 1992
54. Doherty GM, Jensen JC, Alexander HR, Buresh CM, Norton JA: Pentoxifylline suppression of tumor necrosis factor gene transcription. Sugery 110:192, 1991
55. Moreira AL, Sampaio EP, Zmuidzinas A, Frindt P, Smith KA, Kaplan G: Thalidomide exerts its inhibitory action on tumor necrosis factor α by enhancing mRNA degradation. J Exp Med 177:1675, 1993
56. Wei P, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM: Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:17, 1995
57. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123, 1995
58. Duh EJ, Maury WJ, Folks TM, Fauci AS, Rabson AB: Tumor necrosis factor-alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-κB sites in the long terminal repeat. Proc Natl Acad Sci USA 86:5974, 1989
59. Biswas P, Poli G, Kinter AL, Kinter AL, Justement JS, Stanley SK, Maury WJ, Bressler P, Orenstein JM, Fauci AS: Interferon-gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells. J Exp Med 176:739, 1992