Amphotericin B is Incompatible with Lipid Emulsions

Annals of Pharmacotherapy

Volumn 30, Issue 3, 1996, Pages 298-

  Ericsson, Orjan ^a   Hallmén, Ann Christin ^b   Wikstrom, Inger ^c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Laboratory Technician ^*

^c Laboratory Technician   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; LIPID EMULSION;

DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; DRUG STABILITY; LETTER; LIPID SOLUBILITY; PRIORITY JOURNAL;

AMPHOTERICIN B; ANTIBIOTICS, ANTIFUNGAL; DRUG INCOMPATIBILITY; EMULSIONS;

EID: 0029932155     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/106002809603000318     Document Type: Letter

References (7)

1. Kirsh R, Goldstein R, Tarloff J, Parris D, Hook J, Hanna N, et al. An emulsion formulation of amphotericin B improves the therapeutic index when treating systemic murine candidiasis. J Infect Dis 1988;158: 1065-70.
2. Moreau P, Milpied N, Fayette N, Ramée J-F, Harousseau JL. Reduced renal toxicity and improved clinical tolerance of amphotericin B mixed with Intralipid compared with conventional amphotericin B in neutrogenic patients. J Antimicrob Chemother 1992;30:535-41.
3. Chavanet PY, Garry I, Charlier N, Caillot D, Kisterman JP, D'Athis M, et al. Trial of glucose versus fat emulsion in preparation of amphoteric in for use in HIV infected patients with candidiasis. BMJ 1992;305:921-5.
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6. Jurgens RW, DeLuca PP, Papadimitriou D. Compatibility of amphotericin B with certain large-volume parenterals. Am J Hosp Pharm 1981;38:377-8.
7. Margosis M, Aszalos A. Quantitation of amphotericin by reverse-phase high-performance liquid chromatography. J Pharm Sci 1984;73: 835-8.