How do polymers prolong circulation time of liposomes?

Journal of Liposome Research

Volumn 6, Issue 1, 1996, Pages 99-116

  Torchilin, Vladimir P ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; LIPOSOME; MACROGOL; POLYACRYLAMIDE; POLYMER; POLYVINYL ALCOHOL; POVIDONE;

ANIMAL EXPERIMENT; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG STABILITY; HYDROPHOBICITY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OPSONIZATION; PHARMACEUTICS; PRIORITY JOURNAL; REVIEW;

EID: 0029932136     PISSN: 08982104     EISSN: None     Source Type: Journal    
DOI: 10.3109/08982109609037204     Document Type: Review

References (22)

1. Pharmaceutical Particulate Carriers, 1993, A. Rolland (Ed.), Marcel Dekker, Inc. New York.
2. Liposomes as Drug Carriers, 1988, G. Gregoriadis (Ed.), John Wiley & Sons, New York.
3. R. Müller, R. 1991. Carriers for Controlled Drug Delivery and Targeting, CRC Press, Boca Raton.
4. Klibanov, A.L., Maruyama, K., Torchilin, V.P. and Huang, L. 1990. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 268: 235.
5. 1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo. FEBS Lett. 284:263.
6. Woodle, M.C. 1993. Surface-modified liposomes: assesssment and characterization for increased stability and prolonged blood circulation. Chem. Phys. Lip. 64:249.
7. Allen, T.M. 1994. The use of glycolipids and hydrophilic polymers in avoiding rapid uptake of liposomes by the mononuclear phagocyte system. Adv. Drug Deliv. Rev. 13:285.
8. Senior, J., Delgado, C., Fisher, D., Tilcock, C. and Gregoriadis, G. 1991. Influence of surface hydrophilicity of liposomes on their interaction with plasma proteins and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. Biochim. Biophys. Acta 1062:77.
9. Chonn, A., Semple, S.C. and Cullis, P.R. 1992. Association of blood proteins with large unilamellar liposomes in vivo: relation to circulation lifetimes. J. Biol. Chem. 267:18759.
10. Blume, G. and Cevc, G. 1993. Molecular mechanism of the lipid vesicle longevity in vivo. Biochim. Biophys. Acta 1146:157.
11. Senior, J.H. 1987. Fate and behavior of liposomes in vivo: A review of controlling factors. CRC Crit. Rev. Ther. Drug Carriers Syst. 3:123.
12. Naper, D.H. 1983. Polymeric Stabilization of Colloidal Dispersions, Academic Press, New York.
13. Illum, L., Hunneyball, I.M. and Davis, S.S. 1986. The effect of hydrophilic coatings on the uptake of colloidal perticles by the liver and peritoneal macrophages. Int. J. Pharm. 29:53.
14. Moghimi, S.M., Hawley, A.E., Christy, N.M., Gray, T., Illum, L. and Davis, S.S. 1994. Surface engineered nanospheres with enhanced drainage into lymphatics and uptake by macrophages of the regional lymph nodes. FEBS Lett. 344:25.
15. Gabizon, A. and Papahadjopoulos, D. 1992. The role of surface charge and hydrophilic groups on liposome clearance in vivo. Biochim. Biophys. Acta 1103:94.
16. Torchilin, V.P., Omelyanenko, V.G., Papisov, I.M., Bogdanov, A.A. Jr., Trubetskoy, V.S., Herron, J.N. and Gentry, C.A. 1994. Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity. Biochim. Biophys. Acta 1195:11.
17. Torchilin, V.P. and Papisov, M.I. 1994. Why do polyethylene glycol-coated liposomes circulate so long? J. Liposome Res. 4:725.
18. des Cloizeaux, J. and Jannink, G. 1990. Polymers in Solution. Their Modelling and Structure, Clarendon Press, Oxford.
19. Kurata, M. and Tsunashima, Y. 1989. Viscosity - molecular weight relationships and unperturbed dimensions of linear chain molecules. In "Polymer Handbook." J. Brandup and E.H. Himmelgut (Eds.). Wiley, New York, p.VII/1.
20. Torchilin, V.P., Klibanov, A.L., Huang, L., O'Donnell, S., Nossiff, N.D. and Khaw, B.A. 1992. Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium. FASEB J. 6:2716.
21. Allen, T.M. and Hansen, C. 1991. Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim. Biophys. Acta 1068:133.
22. Torchilin, V.P., Shtilman, M.I., Trubetskoy, V.S., Whiteman, K. and Milstein, A.M. 1994. Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo. Biochim. Biophys. Acta 1195:181.