Absence of mutations at codon 768 of the RET proto-oncogene in sporadic and hereditary pheochromocytomas

Endocrine Journal

Volumn 43, Issue 1, 1996, Pages 109-114

  Yoshimoto, Katsuhiko ^a   Kimura, Takehiko ^a   Tanaka, Chisato ^a   Moritani, Maki ^a   Iwahana, Hiroyuki ^a   Itakura, Mitsuo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Codon 768; Exon 13; Mutation; Pheochromocytoma; RET proto oncogene

Indexed keywords

ADULT; AGED; ARTICLE; CARCINOGENESIS; CODON; EXON; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; PHEOCHROMOCYTOMA; PROTO ONCOGENE;

EID: 0029932083     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.43.109     Document Type: Article

References (19)

1. Takahashi M, Buma Y, Iwamoto T, Inaguma Y, Ikeda H, Hiai H (1988) Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene 3: 571-578.
2. Mulligan LM, Kwok JBJ, Healey CS, Elsdon MJ, Eng C, Gardner E, Love DR, Mole SE, Moore JK, Papi L, Ponder MA, Telenius H, Tunnacliffe A, Ponder BAJ (1993) Germline mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363: 458-160.
3. Hofstra RMW, Landsvater RM, Ceccherini I, Stulp RP, Stelwagen T, Luo Y, Pasini B, Hoppener JWM, van Amstel HKP, Romeo G, Lips CJM, Buys CHC (1994) A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature 367: 375-376.
4. Donis-Keller H, Dou S, Chi D, Carlson KM, Toshima K, Lairmore TC, Howe JR, Moley JF, Goodfellow PJ, Wells SA Jr (1993) Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum Mol Genet 2: 851-865.
5. Mulligan LM, Eng C, Healey CS, Clayton D, Kwok JBJ, Gardner E, Ponder MA, Frilling A, Jackson CE, Lehnert H, Neuman HPH, Thibodeau SN, Ponder BAJ (1993) Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC. Nature Genet 6: 70-74.
6. Carlson KM, Dou S, Chi D, Scavarda N, Toshima K, Jackson CE, Wells SA Jr, Goodfellow PJ, Donis-Keller H (1994) Single missense mutation in the tyrosine kinase catalytic domain of the RET proto-oncogene is associated with multiple endocrine neoplasia type 2B. Proc Natl Acad Sci USA 91: 1579-1583.
7. Eng C, Smith DP, Mulligan LM, Nagai MA, Healey CS, Ponder MA, Gardner E, Scheumann GFW, Jackson CE, Tunnacliffe A, Ponder BAJ (1994) Point mutations within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours. Hum Mol Genet 3: 237-241.
8. Eng C, Smith DP, Mulligan LM, Healey CS, Zvelebil MJ, Stonehouse TJ, Ponder MA, Jackson CE, Waterfield MD, Ponder BAJ (1995) A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC. Oncogene 10: 509-513.
9. Yoshimoto K, Tanaka C, Hamaguchi S, Kimura T, Iwahana H, Miyauchi A, Itakura M (1995) Tumor specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type. Endocrine J 42: 265-270.
10. Yoshimoto K, Iwahana H, Fukuda A, Sano T, Saito S, Itakura M (1992) Role of p53 mutations in endocrine tumorigenesis: Mutation detection by polymerase chain reaction-single strand conformation polymorphism. Cancer Res 52: 5061-5064.
11. Ceccherini I, Hofstra RMW, Luo Y, Stulp RP, Barone V, Stelwagen T, Bocciardi R, Nijveen H, Bolino A, Seri M, Ronchetto P, Pasini B, Bozzano M, Buys CHCM, Romeo G (1994) DNA polymorphisms and conditions for SSCP analysis of the 20 exons of the ret proto-oncogene. Oncogene 9: 3025-3029.
12. Santro M, Carlomagno F, Romano A, Bottaro DP, Dathan NA, Grieco M, Fusco A, Vecchio G, Matoskova B, Kraus MH, Di Fiore PP (1995) Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science 267: 381-383.
13. Asai N, Iwashita T, Matsuyama M, Takahashi M (1995) Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 15: 1613-1619.
14. Blaugrund JE, Johns MM, Eby YJ, Ball DW, Baylin SB, Hruban RH, Sidransky D (1994) RET proto-oncogene mutations in inherited and sporadic medullary thyroid cancer. Hum Mol Genet 3: 1895-1897.
15. Eng C, Mulligan LM, Smith DP, Healey CS, Frilling A, Raue S, Neumann HPH, Pfagner R, Behmel A, Lorenzo MJ, Stonehouse TJ, Ponder MA, Ponder BAJ (1995) Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma. Genes, Chromosomes & Cancer 12: 209-212.
16. Kimura T, Yoshimoto K, Yokogoshi Y, Saito S (1995) Mutations in the cysteine-rich region of the RET proto-oncogene in patients diagnosed as having sporadic medullary thyroid carcinoma. Endocrine J 42: 517-525.
17. Lindor NM, Honchel R, Khosla S, Thibodeau SN (1995) Mutations in the RET protooncogene in sporadic pheochromocytomas. J Clin Endocrinol Metab 80: 627-629.
18. Wells SA Jr, Donis-Keller H (1994) Current perspectives on the diagnosis and management of patients with multiple endocrine neoplasia type 2 syndromes. Endocrinol Metab Clin North Am 23: 215-228.
19. Tsuzuki T, Takahashi M, Asai N, Iwashita T, Matsuyama M, Asai J (1995) Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene 10: 191-198.