Albendazole chemotherapy for treatment of diarrhoea in patients with AIDS in Zambia: A randomised double blind controlled trial

British Medical Journal

Volumn 312, Issue 7040, 1996, Pages 1187-1191

  Kelly, Paul ^a,d   Lungu, Florence ^a   Keane, Eileen ^b   Baggaley, Rachel ^c   Kazembe, Frida ^a   Pobee, Joseph ^a   Farthing, Michael ^d  

^a UNIVERSITY TEACHING HOSPITAL   (Zambia)

^b Ndola Central Hospital   (Zambia)

^c Kara Counselling and Training Trust   (Zambia)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; ANTHELMINTIC AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HOME CARE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMISSION; URBAN AREA; ZAMBIA;

EID: 0029931821     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.312.7040.1187     Document Type: Article

References (23)

1. Piot P, Kapita BM, Were JBO, Laga M, Colebunders RL. AIDS in Africa: the first decade and challenges for the 1990s. AIDS 1991;5(suppl 1):S1-5.
2. Gilks C. The clinical challenge of the HIV epidemic in the developing world. Lancet 1993;342:1037-9.
3. Mulder DW, Nunn AJ, Kamali A, Nakiyingi J, Wagner H-U, Kengeya-Kayondo JF. Two year HIV-1 associated mortality in a Ugandan rural population. Lancet 1994;343:1021-3.
4. Foster S. Maize production, drought and AIDS in Monze district, Zambia. Health Policy and Planning 1993;8:247-54.
5. Garnett GP, Anderson RM. No reason for complacency about the potential demographic impact of AIDS in Africa. Trans R Soc Trop Med Hyg 1993;87(suppl 1):19-22.
6. Colebunders RL, Latif AS. Natural history and clinical presentation of HIV-1 infection in adults. AIDS 1991;5(suppl 1):S103-12.
7. Fylkesnes K, Brunborg H, Msiska R. The socio-economic impact of AIDS; background paper I: Zambia; the current HIV/AIDS situation and future demographic impact. Lusaka: Ministry of Health, 1994.
8. Gazzard BG, Blanshard C. Diarrhoea in AIDS and other immunodeficiency states. Baillieres Clin Gastroenterol 1993;7:387-419.
9. Kelly P, Baboo KS, Wolff M, Ngwenya B, Luo NP, Farthing MJG. The prevalence and aetiology of persistent diarrhoea in adults in urban Zambia. Acta Tropica (in press).
10. Drobniewski F, Kelly P, Carew A, Ngwenya B, Luo N, Pankhurst C, et al. Human microsporidiosis in African AIDS patients with chronic diarrhea. J Infect Dis 1995;171:515-6.
11. Conlon C, Pinching AP, Perera CU, Moody A, Luo NP, Lucas SB. HIV related enteropathy in Zambia: a clinical, microbiological and histological study. Am J Trop Med Hyg 1990;42:83-8.
12. Chela CM, Siankanga ZC. Home and community care: the Zambia experience. AIDS 1991;5(suppl 1):S157-61.
13. Blanshard C, Ellis DS, Tovey DG, Dowell S, Gazzard BG. Treatment of intestinal microsporidiosis with albendazole in patients with AIDS. AIDS 1992;6;311.
14. Archibald LK, Beeching NJ, Gill GV, Bailey JW, Bell DR. Albendazole is effective treatment for chronic strongyloidiasis. Q J Med 1993;86:191-5.
15. Meloni BP, Thompson RCA, Reynoldson JA, Seville P, Albendazole: a more effective antigiardial agent in vitro than metronidazole or tinidazole. Trans R Soc Trop Med Hyg 1990;84:375-9.
16. Karnofsky DA, Abelmann WH, Craver LF, Burchenal JH. The use of the nitrogen mustards in the palliative treatment of carcinoma. Cancer 1948;1:634-56.
17. Lucas SB, De Cock KM, Hounnou A, Peacock C, Diomande M, Honde M, et al. Contribution of tuberculosis to slim disease in Africa. BMJ 1994;308:1531-3.
18. Shanson DC. Septicaemia in patients with AIDS. Trans R Soc Med Hyg 1990;84(suppl 1):14-6.
19. Cali A, Kotler DP, Orenstein JM. Septata intestinalis ng, nsp, an intestinal microsporidian associated with chronic diarrhoea and dissemination in AIDS patients. J Eukaryot Microbiol 1993;40:101-12.
20. Molina JM, Oksenhendler E, Beauvais B, Sarfati C, Jaccard A, Derouin F, et al. Disseminated microsporidiosis due to Septata intestinalis in patients with AIDS: clinical features and response to albendazole therapy. J Infect Dis 1995;171:245-9.
21. Kelly P, Buve A. Chemotherapy of African AIDS diarrhoea: a preliminary study. AIDS 1993;7:91-3.
22. Byar DP, Schoenfeld DA, Green SB, Amato DA, Davis R, De Gruttola V, et al. Design considerations for AIDS trials. N Engl J Med 1990;323:1343-7.
23. Foster SD. Affordable clinical care for HIV related illness in developing countries. Tropical Diseases Bulletin 1990;87:R1-9.