Disposition and protective effect against irritation after intravenous and rectal administration of indomethacin loaded nanocapsules to rabbits

International Journal of Pharmaceutics

Volumn 133, Issue 1-2, 1996, Pages 107-115

  Fawaz, F ^a   Bonini, F ^a   Guyot, M ^a   Lagueny, A M ^a   Fessi, H ^b   Devissaguet, J P ^b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b UNIV PARIS SUD   (France)

Author keywords

Biodegradable nanocapsules; Indomethacin; Pharmacokinetics; Poly(D,L lactide); Rectal irritation

Indexed keywords

BENZYL BENZOATE; DRUG CARRIER; INDOMETACIN; NANOPARTICLE; POLOXAMER; POLYLACTIDE; RESOMER R 206; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DOSAGE FORM; DRUG HALF LIFE; ENTEROHEPATIC CIRCULATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RABBIT; RECTAL DRUG ADMINISTRATION; RECTUM INJURY; SUPPOSITORY; SUSPENSION;

EID: 0029931644     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04424-8     Document Type: Article

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