Increased β-amyloid precursor protein mRNA in the rat cerebral cortex and hippocampus after chronic systemic atropine treatment

Neuroscience Letters

Volumn 210, Issue 1, 1996, Pages 13-16

  Beach, Thomas G ^a   Walker, Douglas G ^a   Cynader, Max S ^a   Hughes, Linda H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Aging brain; Alzheimer's disease; Animal model; Cholinergic receptor; Amyloid precursor protein

Indexed keywords

AMYLOID BETA PROTEIN; ATROPINE; MESSENGER RNA; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; CHOLINERGIC SYSTEM; CONTROLLED STUDY; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029931413     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12650-1     Document Type: Article

References (18)

1. Beani, L., Bianchi, C., Ferraro, L., Nilsson, L., Nordberg, A., Romanelli, L., Spalluto, P., Sundwall, A. and Tanganelli, S., Effect of nicotine on the release of acetylcholine and amino acids in the brain. In A. Nordberg, K. Fuxe, B. Holmstedt and A. Sundwall (Eds.), Progress in Brain Research, Vol. 79, Elsevier, Amsterdam, 1989, pp. 149-155.
2. Beyreuther, K., Pollwein, P., Multhaup, G., Monning, U., Konig, G., Dyrks, T., Schubert, W. and Masters, C.L., Regulation and expression of the Alzheimer's β/A4 amyloid protein precursor in health, disease and Down's syndrome, Ann. N. Y. Acad. Sci., 695 (1993) 91-102.
3. Cummings, B.J., Su, J.H., Cotman, C.W., White, R. and Russell, M.J., β-Amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease, Neurobiol. Aging, 14 (1993) 547-560.
4. Dagerlind, A., Friberg, K., Bean, A.J. and Hokfelt, T., Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry, Histochemistry, 98 (1992) 39-49.
5. Davies, L., Wolska, B., Hilbich, C., Multhaup, G., Martins, R., Simms, G., Beyreuther, K. and Masters, C.L., A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques, Neurology, 38 (1988) 1688-1693.
6. Egan, T.M. and North, R.A., Actions of acetylcholine and nicotine on rat locus coeruleus neurons in vitro, Neuroscience, 19 (1986) 565-571.
7. Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., Mant, R., Newton, P., Rooke, K., Roques, P., Talbot, C., Pericak-Vance, M., Roses, A., Williamson, R., Rossor, M., Owen, M. and Hardy, J., Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease, Nature, 349 (1991), 704-706.
8. Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D.M., Oshima, J., Pettingell, W.H., Yu, C.-en, Jondro, P.D., Schmidt, S.D., Wang, K., Crowley, A.C., Fu, Y.-H., Guenette, S.Y., Galas, D., Nemens, E, Wijsman, E.M., Bird, T.D., Schellenberg, G.D. and Tanzi, R.E., Candidate gene for the chromosome 1 familial Alzheimer's disease locus, Science, 269 (1995) 973-977.
9. McKinney, M. and Robbins, M., Chronic atropine administration up-regulates rat cortical muscarinic ml receptor molecules: assessment with the RT/PCR, Mol. Brain Res., 12 (1992) 39-45.
10. Molenaar, P.C. and Polak, R.L., Stimulation by atropine of acetylcholine release and synthesis in cortical slices from rat brain, Br. J. Pharmacol., 40 (1970) 406-417.
11. Nitsch, R.M., Slack, B.E., Wurtman, R.J. and Growdon, J.H., Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors, Science, 258 (1992) 304-307.
12. Perry, E.K., Court, J.A., Piggott, M.A., and Perry, R.H. Cholinergic component of dementia and aging. In F.A. Huppert, C. Brayne and D.W. O'Connor (Eds.), Dementia and Normal Aging, Cambridge University Press, Cambridge, 1994, pp. 431-469.
13. Scheuner, D., Bird, T., Citron, M., Lannfelt, L., Schellenberg, G., Selkoe, D., Viitanen, M. and Younkin, S.G., Fibroblasts from carriers of familial AD linked to chromosome 14 show increased Aβ production, Soc. Neurosci. Abstr., 21 (1995) 1500.
14. Shaw, C., Needler, M.C. and Cynader, M., Ontogenesis of muscarinic acetylcholine binding sites in cat visual cortex: reversal of specific laminar distribution during the critical period, Dev. Brain Res., 14 (1984) 295-300.
15. Shivers, B.D., Hilbich, C., Multhaup, G., Salbaum, M., Beyreuther, K. and Seeburg, P.H., Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact, EMBO J., 7 (1988) 1365-1370.
16. Strittmatter, W.J., Saunders, A.M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G.S. and Roses, A.D., Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90 (1993) 1977-1981.
17. Wall, S.J., Yasuda, R.P., Li, M., Ciesla, W. and Wolfe, B.B., Differential regulation of subtypes m1-m5 of muscarinic receptors in forebrain by chronic atropine administration, J. Pharmacol. Exp. Ther., 262 (1992) 584-588.
18. Wallace, W., Ahlers, S.T., Gotlib, J., Bragin, V., Sugar, J., Gluck, R., Shea, P.A., Davis, K.L. and Haroutunian, V., Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation, Proc. Natl. Acad. Sci. USA, 90 (1993) 8712-8716.