Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells

Cancer Research

Volumn 56, Issue 10, 1996, Pages 2387-2392

  Okazaki, Michiko ^a   Kishida, Shosei ^a   Murai, Hiroshi ^a   Hinoi, Takao ^a   Kikuchi, Akira ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CELL TRANSFORMATION; COLONY FORMING UNIT; ENHANCER REGION; GENE EXPRESSION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE C FOS; ONCOGENE RAS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION;

3T3 CELLS; ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL ADHESION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; ENHANCER ELEMENTS (GENETICS); FARNESYLTRANSTRANSFERASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, FOS; GENES, NEUROFIBROMATOSIS 1; GENES, RAS; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; ONCOGENE PROTEIN P21(RAS); ONCOGENE PROTEINS V-RAF; PEPTIDE FRAGMENTS; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RAL GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; RETROVIRIDAE PROTEINS, ONCOGENIC; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERASES;

EID: 0029931169     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Barbacid, M. ras genes. Annu. Rev. Biochem., 56: 779-827, 1987.
2. Bos, J. L ras oncogenes in human cancer: a review. Cancer Res., 49: 4682-4689, 1989.
3. Lowy, D R , and Willumsen, B. M Function and regulation of ras Annu. Rev. Biochem., 62: 851-891, 1993
4. ras with GAP, exchange factors, and its biological effector target J. Biol Chem., 268: 9157-9160, 1993.
5. Noda, M. Structures and functions of the K rev-1 transformation suppressor gene and its relatives. Biochim. Biophys. Acta, 1155: 97-109, 1993
6. Langer, S. J., Bortner, D. M , Roussel, M F., Sherr, C. J., and Ostrowski, M. C. Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression. Mol. Cell Biol., 12: 5355-5362, 1992.
7. Kohl, N. E., Mosser, S. D , deSolms, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L , Scolnick, E. M., Oliff, A., and Gibbs, J. B. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor Science (Washington DC), 260: 1934-1937, 1993.
8. James, G. L., Goldstein, J. L., Brown, M S., Rawson, T. E. Somers, T. C., McDowell, R. S., Crowley, C. W., Lucas, B K., Levinson, A D., and Marsters, J. C., Jr. Benzodiazepine peptidomimetics. potent inhibitors of Ras farnesylation in animal cells. Science (Washington DC), 260: 1937-1942, 1993.
9. Egan, S. E., and Weinberg, R. A. The pathway to signal achievement. Nature (Lond.), 365. 781-783, 1993.
10. Avruch, J., Zhang, X F., and Kyriakis, J. M. Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem. Sci., 19: 279-283, 1994.
11. Vojtek, A. B., Hollenberg, S. M., and Cooper, J. A Mammalian Ras interacts directly with the serine/threonine kinase Raf Cell, 74: 205-214, 1993.
12. Warne, P. H , Viciana, P. R , and Downward, J. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature (Lond), 364: 352-355, 1993.
13. Moodie, S. A., Willumsen, B. M., Weber, M J., and Wolfman, A. Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase. Science (Washington DC), 260. 1658-1661, 1993.
14. Koide, H., Satoh, T , Nakafuku, M., and Kaziro, Y. GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells. Proc. Natl. Acad. Sci. USA, 90: 8683-8686, 1993.
15. Kikuchi, A , and Williams, L T The post-translational modification of ras p21 is important for Raf-1 activation. J. Biol Chem., 269 20054-20059, 1994
16. Fridman, M , Tikoo, A , Varga, M., Murphy, A , Nur-E-Kamal, M. S A , and Maruta, H. The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras-induced malignant phenotype. J Biol Chem , 209: 30105-30108, 1994.
17. Rodriguez-Viciana, P., Warne, P H , Dhand, R , Vanhaesebroeck, B., Gout, I., Fry, M. J , Waterfield, M D , and Downward, J Phosphatidylinositol-3-OH kinase as a direct target of Ras Nature (Lond.), 370. 527-532, 1994.
18. Russell, M., Lange Carter, C. A., and Johnson, G. L. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J. Biol. Chem., 270. 11757-11760, 1995.
19. Nur-E-Kamal, M. S. A., Varga, M., and Maruta, H The GTPase-activating NF1 fragment of 91 amino acids reverses v-Ha-Ras-induced malignant phenotype. J. Biol. Chem , 268 22331-22337, 1993.
20. Kikuchi, A., Demo, S. D., Ye, Z H., Chen, Y. W., and Williams, L. T. ralGDS family members interact with the effector loop of ras p21. Mol. Cell. Biol., 14: 7483-7491, 1994
21. Albright, C. F., Giddings, B. W., Liu, J., Vito, M , and Weinberg, R. A. Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase EMBO J., 12: 339-347, 1993
22. Chardin, P., and Tavitian, A The ral gene: a new ras related gene isolated by the use of a synthetic probe EMBO J , 5: 2203-2208, 1986
23. Hofer, F., Fields, S., Schneider, C , and Martin, G. S Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. Proc Natl Acad. Sci. USA, 91 11089-11093, 1994
24. Spaargaren, M., and Bischoff, J. R. Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap Proc Natl. Acad Sci. USA, 91: 12609-12613, 1994.
25. Ikeda, M., Koyama, S., Okazaki, M., Dohi, K., and Kikuchi, A rap1 p21 regulates the interaction of ras p21 with RGL, a new effector protein of ras p21. FEBS Lett., 375: 37-40, 1995.
26. Koyama, S., Chen, Y-W , Ikeda, M., Muslin, A. J , Williams, L. T , and Kikuchi, A. Ras-interacting domain of RGL blocks Ras-dependent signal transduction in Xenopus oocytes. FEBS Lett., 380: 113-117, 1996.
27. Wilson, I. A., Niman, H. L., Houghten, R A., Cherenson, A R., Connolly, M. L., and Lerner, R. A. The structure of an antigenic determinant in a protein. Cell, 37: 767-778, 1984.
28. Hu, Q., Klippel, A., Muslin, A. J., Fantl, W. J., and Williams, L. T. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science (Washington DC), 268: 100-102, 1995.
29. Quilliam, L. A., Kato, K., Rabun, K M., Hisaka, M. M., Huff, S. Y., Campbell-Burk, S., and Der, C. J. Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors. Mol. Cell. Biol., 14: 1113-1121, 1994
30. Sakoda, T., Kaibuchi, K., Kishi, K., Kishida, S., Doi, K., Hoshino, M., Hattori, S., and Takai, Y. smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/ enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells. Oncogene, 7: 1705-1711, 1992.
31. Koyama, S., Williams, L. T., and Kikuchi, A. Characterization of the interaction of Raf-1 with ras p21 or 14-3-3 protein in intact cells. FEBS Lett , 368: 321-325, 1995.
32. Willumsen, B. M., Papageorge, A. G., Kung, H.-F., Bekesi, E., Robins, T., Johnsen, M , Vass, W. C., and Lowy, D. R. Mutational analysis of a ras catalytic domain. Mol. Cell Biol., 6: 2646-2654, 1986.
33. Laemmli, U. K Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond), 227: 680-685, 1970.
34. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem., 72: 248-254, 1976.
35. Kikuchi, A , and Williams, L. T Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase. J. Biol. Chem., 271: 588-594, 1996.
36. Zhang, K., Noda, M., Vass, W C., Papageorge, A. G., and Lowy, D. R. Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1. Science (Washington DC), 249: 162-165, 1990.
37. Nassar, N., Horn, G , Herrmann, C., Scherer, A , McCormick, F., and Wittinghofer, A. The 2 2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. Nature (Lond.), 375: 554-560, 1995.
38. Cantor, S. B., Urano, T., and Feig, L. A. Identification and characterization of Ral-Binding Protein 1, a potential downstream target of Ral GTPases. Mol. Cell Biol., 15: 4578-4584, 1995
39. Jullien-Flores, V., Dorseuil, O., Romero, F., Letourneur, F., Saragosti, S., Berger, R , Tavitian, A , Gacon, G., and Camonis, J. H. Bridging Ral GTPase to Rho pathways RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J Biol. Chem., 270: 22473-22477, 1995.
40. Qiu, R. G., Chen, J., Kim, D , McCormick, F., and Symons, M An essential role for Rac in Ras transformation. Nature (Lond ), 374 457-459, 1995.
41. Coso, O. A., Chiariello, M., Yu, J C., Teramoto, H., Crespo, P., Xu, N., Mita, T , and Gutkind, J. S. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway Cell, 81: 1137-1146, 1995.
42. Minden, A , Lin, A., Claret, F. X., Abo, A., and Karin, M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell, 81: 1147-1157, 1995
43. Hill, C. S., Wynne, J., and Treisman, R. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF Cell, 81: 1159-1170, 1995.
44. Khosravi-Far, R., Solski, P A., Clark, G. J , Kinch, M. S., and Der, C. J. Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases is required for Ras transformation. Mol. Cell. Biol., 15: 6443-6453, 1995.
45. 1. Science (Washington DC), 269: 1270-1272, 1995.
46. Takai, Y., Sasaki, T., Tanaka, K., and Nakanishi, H. Rho as a regulator of the cytoskeleton. Trends Biochem. Sci., 20: 227-231, 1995.
47. White, M A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M., and Wigler, M H Multiple Ras functions can contribute to mammalian cell transformation. Cell, 80. 533-541, 1995.