A role for c-myc in the regulation of thymocyte differentiation and possibly positive selection

Journal of Immunology

Volumn 156, Issue 9, 1996, Pages 3141-3150

  Broussard Diehl, Christine ^a   Bauer, Steven R ^b   Scheuermann, Richard H ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; GENES, MYC; IMMUNOPHENOTYPING; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0029931057     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Von Boehmer, H. 1990. Developmental biology of T cells in T cell-receptor transgenic mice. Annu. Rev. Immunol. 8:531.
2. 2+ thymocytes as post-selection intermediates leading to mature T cells. J. Exp. Med. 173:323.
3. Huesmann, M., B. Scott, P. Kisielow, and H. von Boehmer. 1991. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66:533.
4. +CD3 high thymocyte appears transiently during ontogeny: evidence from phenotypic and functional studies. Eur. J. Immunol. 21:2655.
5. + thymocytes: increased synthesis of TCR-α protein is an early response to TCR signaling that compensates for TCR-α instability, improves TCR assembly, and parallels other indicators of positive selection. J. Exp. Med. 181:193.
6. + thymocyte development defined by the lack of coreceptor binding in positive selection. J. Immunol. 154:2588.
7. + thymocytes. Eur. J. Immunol. 23:739.
8. Bendelac, A., P. Matzinger, R. A. Seder, W. E. Paul, and R. H. Schwartz. 1992. Activation events during thymic selection. J. Exp. Med. 175:731.
9. Crispe, I. N., and M. J. Bevan. 1987. Expression and functional significance of the J11d marker on mouse thymocytes. J. Immunol. 138:2013.
10. - thymocytes lacking heat-stable antigen. Cell. Immunol. 117:312.
11. Chan, S. H., C. Benoist, and D. Mathis. 1993. A challenge to the instructive model of positive selection. Immunol. Rev. 135:119.
12. Chan, S. H., D. Coscrove, C. Waltzinger, C. Benoist, and D. Mathis. 1993. Another view of the selective model of thymocyte selection. Cell 73:225.
13. Davis, C. B., N. Killeen, M. E. Casey Crooks, D. Raulet, and D. Littman. 1993. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73:237.
14. hi thymocytes. J. Exp. Med. 181:1643.
15. Robey, E., and B. J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12:675.
16. Korsmeyer, S. J. 1992. Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Annu. Rev. Immunol. 10:785.
17. Veis, D. J., C. L. Sentman, E. A. Bach, and S. J. Korsmeyer. 1993. Expression of the bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol. 151:2540.
18. Gratiot-Deans, J., L. Ding, L. A. Turka, and G. Nunez. 1993. bcl-2 proto-oncogene expression during human T cell development: evidence for biphasic regulation. J. Immunol. 151:83.
19. Moore, N. C., G. Anderson, G. T. Williams, J. J. T. Owen, and E. J. Jenkinson. 1994. Developmental regulation of bcl-2 expression in the thymus. Immunology 81:115.
20. Sentman, C. L., J. R. Shutter, D. Hockenbery, O. Kanagawa, and S. J. Korsmeyer. 1991. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879.
21. Strasser, A., A. W. Harris, and S. Cory. 1991. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67:889.
22. Siegel, R. M., M. Katsumata, T. Miyashita, D. C. Louie, M. I. Greene, and J. C. Reed. 1992. Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice. Proc. Natl. Acad. Sci. USA 89:7003.
23. Cole, M. D. 1986. The myc oncogene: its role in transformation and differentiation. Ann. Rev. Genet. 20:361.
24. Evan, G. I., and T. D. Littlewood. 1993. The role of c-myc in cell growth. Curr. Opin. Genet. Dev. 3:44.
25. Evan, G. I., A. H. Wylie, C. S. Gilbert, T. D. Littlewood, H. Land, M. Brooks, C. M. Waters, L. Z. Penn, and D. C. Hancock. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119.
26. Fanidi, A., E. A. Harrington, and G. I. Evan. 1992. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature 359:554.
27. Wagner, A. J., M. B. Small, and N. Hay. 1993. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Mol. Cell. Biol. 13:2432.
28. Bissonette, R. P., F. Echeverri, A. Mahboubi, and D. R. Green. 1992. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359:552.
29. Reed, J. C., M. Cuddy, S. Haldar, C. Croce, P. Nowell, D. Makover, and K. Bradley. 1990. bcl-2-mediated tumorigenicity of a human T lymphoid cell line: synergy with Myc and inhibition by Bcl-2 antisense. Proc. Natl. Acad. Sci. USA 87:3660.
30. Askew, D. S., R. A. Ashmun, B. C. Simmons, and J. L. Cleveland. 1991. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6:1915.
31. Shi, Y., J. M. Glynn, L. J. Guilbert, T. G. Cotter, R. P. Bissonette, and D. R. Green. 1992. Role for c-myc in activation-induced cell death in T cell hybridomas. Science 257:212.
32. Liu, Z.-Y., K. Chin, and C. T. Noguchi. 1994. Tissue-specific expression of human erythropoietin receptor in transgenic mice. Dev. Biol. 166:159.
33. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 161: 156.
34. Scheuermann, R. H., and S. R. Bauer. 1993. Polymerase chain reaction-based mRNA quantification using an internal standard: analysis of oncogene expression. Methods Enzymol. 218:446.
35. Scheuermann, R. H., E. Racila, T. Tucker, E. Yefenof, N. E. Street, E. S. Vitetta, L. J. Picker, and J. Uhr. 1994. Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells. Proc. Natl. Acad. Sci. USA 91:4048.
36. Scheuermann, R. H., and S. R. Bauer. 1990. Tumorigenesis in transgenic mice expressing the c-myc oncogene with various lymphoid enhancer elements. Curr. Top. Microbiol. Immunol. 166:221.
37. Strasser, A., A. W. Harris, M. L. Bath, and S. Cory. 1990. Novel primitive lymphoid tumors induced in transgenic mice by cooperation between myc and bcl-2. Nature 348:331.
38. + precursors. Proc. Natl. Acad. Sci. USA 86: 7542.
39. + thymocytes. Eur. J. Immunol. 22:2367.
40. Lundberg, K., and K. Shortman. 1994. Small cortical thymocytes are subject to positive selection. J. Exp. Med. 179:1475.
41. low thymocytes contain precursors of mature T cells. Eur. J. Immunol. 24:1010.
42. Adkins, B., C. Mueller, C. Y. Okada, R. A. Reichert, I. L. Weissman, and G. J. Spangrude. 1987. Early events in T-cell maturation. Annu. Rev. Immunol. 5:325.
43. Yokoyama, W. M., F. Konig, P. J. Kenn, J. M. B. Pereira, G. Stingl, J. E. Coligan, and E. Shevach. 1988. Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J. Immunol. 141:369.
44. Herman, A., J. W. Kappler, P. Marrack, and A. M. Pullen. 1991. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu. Rev. Immunol. 9:745.
45. Strasser, A., A. W. Harris, H. von Boehmer, and S. Cory. 1994. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc. Natl. Acad. Sci. USA 91:1376.
46. + stage during positive selection and promotes differentiation at several control points. Immunity 1:197.
47. Tao, W., S. Teh, I. Melhado, F. Jirik, S. J. Korsmeyer, and H. Teh. 1994. The T cell receptor repertoire is altered by overexpression of the bcl-2 protooncogene in the thymus. J. Exp. Med. 179:145.
48. + mature thymocytes require different post-selection processing for final development. J. Immunol. 151:1273.
49. Miyazaki, T., Z-J. Liu, A. Kawahara, Y. Minami, K. Yamada, Y. Tsujimoto, E. L. Barsoumian, R. M. Perlmutter, and T. Taniguchi. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81:223.
50. Lucas, B., F. Vasseur, and C. Penit. 1993. Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse-labeled thymocytes: correlation with T cell receptor expression. J. Immunol. 151:4574.
51. Marodon, G., and B. Rocha. 1994. Generation of mature T cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation. Eur. J. Immunol. 24:196.
52. Maroun, C. R., and M. Julius. 1994. Distinct roles for CD4 and CD8 as coreceptors in T cell signaling. Eur. J. Immunol. 24:959.
53. Guidos, C. J., and I. L. Weissman. 1990. T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J. Exp. Med. 172:835.
54. low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules. Eur. J. Immunol. 24:1982.
55. Meerwijk, J. P. M., E. M. O'Connell, and R. N. Germain. 1995. Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. J. Immunol. 154:6314.
56. + T cell lineages: a new perspective on thymic commitment and selection. Immunity 2:413.
57. Lucas, B., F. Vasseur, and C. Penit. 1994. Production, selection, and maturation of thymocytes with high surface density of TCR. J. Immunol. 153:53.
58. Anderson, G., J. J. T. Owen, N. C. Moore, and E. J. Jenkinson. 1994. Characteristics of an in vitro system of thymocyte positive selection. J. Immunol. 153: 1915.
59. ras distinguishes positive and negative selection in thymocytes. EMBO J. 14:276.
60. +: thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. J. Exp. Med. 181:927.
61. Ullman, K. S., J. P. Northrup, C. L. Verweij, and G. R. Crabtree. 1990. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu. Rev. Immunol. 8:421.
62. Larsson, L., M. Peltersson, F. Oberg, K. Nilsson, and B. Luscher. 1994. Expression of mad, mxil, max, and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc. Oncogene 9:1247.