Neuroanatomical localization of the effects of (+)-HA966 on locomotor activity after cocaine injections to the nucleus accumbens of rats

Brain Research

Volumn 719, Issue 1-2, 1996, Pages 198-202

  Khan, Meena A ^a   Shoai, Mohammed ^a  

^a NIDA Addiction Research Center   (United States)

Author keywords

Cocaine; Locomotor activity; NMDA receptor glycine site; Nucleus accumbens; Sensitization

Indexed keywords

3 AMINO 1 HYDROXY 2 PYRROLIDINONE; COCAINE; GLYCINE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTRACEREBRAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NEUROANATOMY; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SENSITIZATION;

EID: 0029930730     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00028-5     Document Type: Article

References (24)

1. Bristow, L.J., Hutson, P.H., Thorn, L. and Tricklebank, M.D., The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents, Br. J. Pharmacol., 108 (1993) 1156-1163.
2. Fallon, J.H. and Moore, R.Y., Catecholamine innervation of the basal forebrain IV. Topography of the dopamine projection to the basal forebrain and neostriatum, J. Comp. Neurol., 180 (1978) 545-580.
3. Heidbreder, C.A., Goldberg, S.R. and Shippenberg, T.S., The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioural sensitization in the rat, Brain Res., 616 (1993) 335-338.
4. Hutson, P.H., Bristow, L.J. and Tricklebank, M.D., R-(+)-HA966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine, Br. J. Pharmacol. 103 (1991) 2037-2044.
5. Kalivas, P.W. Sorg, B.A. and Hooks M.S., The pharmacology and neural circuitry of sensitization to psychomotor stimulants, Behav. Pharmacol., 4 (1993) 315-334
6. Kalivas, P.W. and Alesdatter, J.E., Involvement of N-methyl-D-aspartate receptor stimulation in the ventral tegmental area and amygdala in behavioral sensitization to cocaine, J. Pharmacol. Exp. Ther., 267 (1993) 486-495.
7. Kalivas, P.W. and Stewart, J., Dopamine transmission in drug-and stress-induced behavioural sensitization, Brain Res. Rev., 16 (1991) 223-244.
8. Karler, R. and Calder, L.D., Excitatory amino acids and the actions of cocaine, Brain Res., 582 (1992) 143-146.
9. Karler, R., Calder, L.D., Chaudhry, I.A. and Turkanis, S.A., Blockade of 'reverse tolerance' to cocaine and amphetamine by MK801, Life Sci., 46 (1989) 599-606.
10. Kelley, A.E. and Domesick, V.B., The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: an anterograde and retrograde horseradish peroxidase study, Neuroscience, 7 (1982) 2321-2335.
11. Kelley, A.E., Domesick, V.B. and Nauta, W.J.H., The amygdalostriatal projection in the rat - an anatomical study by anterograde and retrograde tracing methods, Neuroscience, 7 (1982) 615-630.
12. Morrow, B.A., Clark, W.A. and Roth, R.H., Stress activation of mesocorticolimbic dopamine neurons: effects of a glycine/NMDA receptor antagonist, Eur. J. Pharmacol., 238 (1993) 255-262.
13. Morrow, B.A., Taylor, J.R. and Roth, R.H., R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures, Brain Res., 673 (1995) 165-169.
14. Pellegrino, L.J., Pellegrino, A.S. and Cushman, A.J., A Stereotaxic Atlas of the Rat Brain, Plenum, New York, 1979.
15. Pulvirenti, L., Swerdlow, N.R. and Koob, G.F., Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine, Pharmacol. Biochem. Behav., 40 (1991) 841-845.
16. Shoaib, M., Shippenberg, T.S., Goldberg, S.R. and Schindler, C.W., Behavioral studies with the glycine partial agonist (+)-HA966 on cocaine-induced locomotor activity and reinforcement, Behav. Pharmacol., 6 (1995) 568-576.
17. Singh, L., Donald, A.E., Foster, A.C., Hutson, P.H., Iversen, L.L., Iversen, S.D., Kemp, J.A., Leeson, P.D., Marshall, G.R., Oles, R.J., Priestley, T., Thorn, L., Tricklebank, M.D., Vass, C.A. and Williams, B.J., Enantiomers of HA-966 (3-amino-1-hydroxypyrolid-2-one) exhibit disinct central nervous system effects: (+)-HA966 is a selective glycine/N-methyl-D-aspartate receptor antagonist but (-)-HA966 is a potent γ-butyrolactone-like sedative, Proc. Natl. Acad. Sci. USA, 87 (1990) 347-351.
18. Tricklebank, M.D. and Saywell, K., Behavioural properties of antagonists acting at the glycine modulatory site on the NMDA receptor/ion channel complex, Soc. Neurosci. Abstr., 16 (1990) 462
19. Trujillo, K.A. and Akil, H., Excitatory amino acids and drugs of abuse: a role for N-methyl-D-aspartate receptors in drug tolerance, sensitization and physical dependence, Drug Alcohol Depend., 38 (1995) 139-154
20. Willetts, J., Balster, R.L. and Leander, J.D., The behavioral pharmacology of NMDA receptor antagonists, Trends Pharmacol. Sci., 11 (1990) 423-428
21. Wilmot, C.A., Excitatory amino acid antagonists: Behavioral and biochemical approaches for the development of new central nervous system therapeutic agents, Drug Dev. Res., 17 (1989) 339-365.
22. Witkin, J.M., Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists, Life Sci., 53 (1993) 405-410.
23. Witkin, J.M., Role of NMDA receptors in behavior and behavioral effects of drugs. In T.W. Stone (Ed.) CNS Neurotransmitters and Neuromodulators: Glutamate, CRC Press, Boca Raton, 1995, pp. 323-350.
24. Yoshikawa, T., Shibuya, H., Kaneno, S. and Toru, M., Blockade of behavioral sensitization to methamphetamine by lesion of the hippocampo-accumbal pathway, Life Sci., 48 (1991) 1325-1332.