Osteoblast cells (MG-63 and HOS) have aromatase and 5α - reductase activities

Biochemistry and Molecular Biology International

Volumn 39, Issue 1, 1996, Pages 109-116

  Shimodaira, Kazuhisa ^a   Fujikawa, Hiroshi ^a   Okura, Fumiya ^a   Shimizu, Yukiko ^a   Saito, Hiroshi ^a   Yanaihara, Takumi ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

5 reductase; Aromatase; HOS; MG 63; Osteoblast; 3H water release method

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; AROMATASE; ESTROGEN; FADROZOLE; STEROID 5ALPHA REDUCTASE; TRITIUM; WATER;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; OSTEOBLAST; RAT;

ANIMALS; AROMATASE; AROMATASE INHIBITORS; CELLS, CULTURED; ENZYME INHIBITORS; FADROZOLE; HUMANS; OSTEOBLASTS; OXIDOREDUCTASES; PROGESTERONE; RATS; TRITIUM;

EID: 0029930671     PISSN: 10399712     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216549600201111     Document Type: Article

References (20)

1. Barzel, U.S.(1988) Am. J. Med. 85, 847-850.
2. Chesnut III, C.H., Ivey J.L., Gruber, H.E., Matthews, M., Nelp, W.B., Sisom, K, and Baylink, D.J.(1983) Metabolism. 32, 571-580.
3. Smith, E.P., Boyd, J., Frank, G.R., Takahasi, H., Choen, R.M., Specker, B., Williams, T.C., Lubahn, D.B., and Korach, K..S.(1994) N. Engl. J. Med. 336, 1056-1061.
4. Baran, D.T., Bergfeld, M.A., Teitebaum, S.L., and Avioli, L.V.(1978) Calcif. Tissue Res. 26, 103-106.
5. Kasperk, C.H., Wergedal, J.E., Farley, J.R.,Linkhart, T.A., Turner, R.T., and Baylink, D.J. (1989) Endocrinology 124, 1576-1578.
6. Benz, D.J., Haussler, M.R., Thomas, M.A., Speelman, B., and Komm, B.S.(1991) Endocrinology 128, 2723-2730.
7. Eriksen, E.F., Colvard, D.S., Berg, N.J., Graham, M.L., Mann, K.G., Spelsberg, T.C., and Riggs, B.L. (1988) Science 241, 84-86.
8. Komm, B.S., Terpening, C.M., Benz, D.J., Graeme, K.A., Gallegos, A., Korc, M., Greene, G.L., O'Malley, B.W., and Haussler, M.R.(1988) Science 241, 81-84.
9. Colvard, D.S., Eriksen, E.F., Keeting, P.E., Wilson, E.M., Lubahn, D.B., French, P.S., Riggs, B.L., and Spelsberg, T.C.(1989) Proc. Natl. Acad. Sci. USA. 86, 854-857.
10. Orwoll, E.S., Stribrska, L., Ramsey, E.E., and Keenan, E.J.(1991) Galcif. tissue Int. 49, 183-187.
11. Vittek, J., Altman, K., Gordon, G.G., and Southren, A.L.(1974) Endocrinology 94, 325-329.
12. Turner, R.T., Bleiberg, B., Colvard, D.S., Keeting, P.E., Evans, G., and Spelsberg, T.C.(1990) J. Bone Mineral Res. 5, 775-779.
13. Suwa, H., Fujikawa, H., Shimodaka, K., Ookura P., SAITO, H., and Yanaihara, T., (1995) Fola Endocrinologica Japonica (in Japanese) 71, 651-658.
14. Bruch, H.R., Wolf, L., Budde, R., Romalo, G., and Schweikert, H.U.(1992) J. Clin. Endocrinol. Metab. 75, 101-105.
15. Tanaka, S., Haji, M., Nishi, Y., Yanase, T., Takayanagi, R., and Nawata, H.(1993) Calcif. Tissue Int. 52, 107-109.
16. Purohit, A., Flanagan, A.M., and Reed, M.J.(1992) Endocrinology 131, 2027-2029.
17. Tada, A., Yarborough, C., and Osawa, Y.(1990) Endocrinology 126(S), A-987, 271.
18. Normington, K., and Russell, D.W.(1992) J. Biol. Chem. 267, 19548-19554.
19. Delos, S., Iehle, C., Martin, P.M., and Raynaud, J.P.(1994) J. Steroid Biochem. Mol. Biol. 48, 347-352.
20. Santen, R.J., Langecker, P., Santner, S.J., Sikka, S., Rajfer, J., and Swerdloff, R. (1990) Endocrine. Research 16, 77-91.