Absence of extensive genetic heterogeneity of hepatitis C virus in antibody-negative chronic hepatitis C

Journal of Medical Virology

Volumn 49, Issue 2, 1996, Pages 87-90

  Kao, J H ^a   Chen, P J ^a   Yang, P M ^a   Lai, M Y ^a   Wang, T H ^a   Chen, D S ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Chronic hepatitis C; Genetic variation; HCV EIA; RT PCR

Indexed keywords

HEPATITIS C VIRUS; MIRIDAE;

VIRUS ANTIBODY;

ADULT; AMINO ACID SEQUENCE; ANTIBODY DETECTION; ARTICLE; CLINICAL ARTICLE; FEMALE; GENETIC VARIABILITY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MALE; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; CAPSID; CHRONIC DISEASE; FEMALE; GENETIC HETEROGENEITY; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION;

EID: 0029930656     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1096-9071(199606)49:2<87::aid-jmv3>3.0.co;2-f     Document Type: Article

References (16)

1. Alter MJ, Margolis HS, Krawczynski K, Judson FN, Mares A, Alexander WJ, Hu PY, Miller JK, Gerber MA, Sampliner RE, Meeks EL, Beach MJ (1992): The natural history of community-acquired hepatitis C in the United States. New England Journal of Medicine 327: 1899-1905.
2. Chen PJ, Lin MH, Tai KF, Liu PC, Lin CJ, Chen DS (1992): The Taiwanese hepatitic C virus genome: Sequence determination and mapping the 5′ termini of viral genomic and antigenomic RNA. Virology 188:102-113.
3. Chien DY, Choo QL, Tabrizi A, Kuo C, McFarland J, Berger K, Lee C, Shuster JR, Nguyen T, Moyer DL, Tong M, Furuta S, Omata M, Fong CT, Tegtmeier G, Alter H, Schiff E, Jeffers L, Houghton M, Kuo G (1993): Use of recombinant HCV antigen in the serodiagnosis of hepatitis C virus infection: Significant improvement in HCV antibody detection as compared with the first generation HCV C100-3 ELISA and the synthetic peptide EIA tests. Journal of Gastroenterology and Hepatology 8:333-39.
4. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M (1989): Isolation of a cDNA derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
5. Choo QL, Richman KH, Han JH, Berger K, Lee C, Dong C, Gallegos C, Coit D, Medina-Selby A, Barr PJ, Weiner AJ, Bradley DW, Kuo G, Houghton M (1991): Genetic organization and diversity of the hepatitis C virus. Proceedings of the National Academy of Sciences USA 88:2451-2455.
6. Hosoda K, Omata M, Yokosuka O, Kato N, Ohio M (1992): Nucleotide sequences of 5-1-1 of hepatitis C virus in patients with chronic liver disease. Gastroenterology 102:1039-1043.
7. Houghton M, Weiner A, Han J, Kuo G, Choo QL (1991): Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology 14:381-388.
8. Kao JH, Chen PJ, Yang PM, Lai MY, Sheu JC, Wang TH, Chen DS (1992): Intrafamilial transmission of hepatitis C virus: The important role of infections between spouses. Journal of Infectious Diseases 166:900-903.
9. Kao JH, Chen PJ, Lai MY, Yang PM, Sheu JC, Wang TH, Chen DS (1994): Mixed infections of hepatitis C virus as a factor in acute exacerbation of chronic type C hepatitis. Journal of Infectious Diseases 170:1128-1133.
10. Kao JH, Lai MY, Huang YT, Yang PM, Chen PJ, Sheu JC, Wang TH, Hsu HC, Chen DS (1996): Chronic hepatitis C without anti-hepatitis C antibodies by second generation assay: A clinicopathologic study and demonstration of the usefulness of third generation assay. Digestive Diseases and Sciences 41:161-165.
11. Kuo G, Choo QL, Alter HJ, Gitnick GI, Redeker AG, Purcell RH, Miyamura T, Dienstag JL, Alter MJ, Stevens CE, Tegtmeier GE, Overby LR, Bradley DW, Houghton M (1989): An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244:362-364.
12. Nagayama R, Tsuda F, Okamoto H, Wang Y, Mitsui T, Tanaka T, Miyakawa Y, Mayumi M (1993): Genotype dependence of hepatitis C virus antibodies detectable by the first-generation enzyme-linked immunosorbent assay with C100-3 protein. Journal of Clinical Investigation 92:1529-1533.
13. Nakatsuji Y, Matsumoto A, Tanaka E, Ogata H, Kiyosawa K (1992): Detection of chronic hepatitis C virus infection by four diagnostic systems: First-generation and second-generation enzyme-linked immunosorbent assay, second-generation recombinant immunoblot assay and nested polymerase chain reaction analysis. Hepatology 16:300-305.
14. Nasoff MS, Zebedee SL, Inchauspe G, Prince AM (1991): Identification of an immunodominant epitope within the capsid protein of hepatitis C virus. Proceedings of the National Academy of Sciences USA 88:5462-5466.
15. Sugitani M, Inchauspe G, Shindo M, Prince AM (1992): Sensitivity of serological assays to identify blood donors with hepatitis C viraemia. Lancet 339:1018-1019.
16. Tsai SL, Chen PJ, Hwang LH, Kao JH, Huang JH, Chang TH, Chen DS (1994): Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection. Journal of Hepatology 21:403-411.