Contribution to activity of histidine-aromatic, amide-aromatic, and aromatic-aromatic interactions in the extended catalytic site of cysteine proteinases

Biochemistry

Volumn 35, Issue 13, 1996, Pages 3970-3979

  Brömme, Dieter ^a,b   Bonneau, Pierre R ^a   Purisima, Enrico ^a   Lachance, Paule ^a   Hajnik, Sohini ^a   Thomas, David Y ^a   Storer, Andrew C ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b Arris Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC AMIDE; CYSTEINE PROTEINASE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACIDS; BASE SEQUENCE; BINDING SITES; CATHEPSINS; CLONING, MOLECULAR; CONSERVED SEQUENCE; CYSTEINE ENDOPEPTIDASES; HISTIDINE; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; PAPAIN; PHENYLALANINE; POINT MUTATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; TRYPTOPHAN;

EID: 0029930588     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9523015     Document Type: Article

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