Stress and the immune system in the etiology of anxiety and depression

Pharmacology Biochemistry and Behavior

Volumn 54, Issue 1, 1996, Pages 299-303

  Leonard, Brian E ^a   Song, Cai ^b  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

cortisol; CRF; depression; immune function; neurotransmitters; stress

Indexed keywords

ANTIDEPRESSANT AGENT; CORTICOTROPIN RELEASING FACTOR; CYTOKINE; GLUCOCORTICOID; HYDROCORTISONE; MITOGENIC AGENT; MONOAMINE OXIDASE INHIBITOR; NEUROTRANSMITTER; PROSTAGLANDIN;

ANIMAL MODEL; ANXIETY; BEHAVIOR; CONFERENCE PAPER; DEPRESSION; ENDOCRINE SYSTEM; HORMONE BLOOD LEVEL; HUMAN; IMMUNE SYSTEM; LYMPHOCYTE ACTIVATION; MONOCYTE; NEUTROPHIL; NONHUMAN; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PRIORITY JOURNAL; STRESS;

EID: 0029930432     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02158-2     Document Type: Conference Paper

References (74)

1. Adamec, R. E.; Sayin, U.; Brown, A. The effects of corticotropin releasing factor (CRF) and handling stress on behaviour in the elevated plus maze test of anxiety. J. Psychol. Pharmacol. 5(3): 175-186; 1991.
2. Ader, R., ed. Psychoneuroimmunology. New York: Academic Press; 1981.
3. Ader, R. Forward. In: Leonard, B. E.; Miller, K., eds. Stress, the immune system and psychiatry. Chichester: John Wiley & Sons; 1995:ix-xii.
4. Ader, R.; Cohen, N.; Felten, D. Psychoneuroimmunology: Interactions between the nervous system and the immune system. Lancet 345:99-103; 1995.
5. Arber, N.; Berliner, S.; Tamir, A. The state of leucocyte adhesiveness/aggregation in the peripheral blood: An independent marker of mental stress. Stress Med. 7:75-78; 1991.
6. Arber, N.; Berliner, S.; Tamir, A.; Liberman, M. E.; Pinkhas, J.; Aronson, M. The state of leucocyte adhesiveness/aggregation in the peripheral blood: A new and independent marker of mental stress. Stress Med. 7:75-78; 1991.
7. Baldessarini, R. J. The basis for amine hypotheses in affective disorder: A critical evaluation. Arch Gen. Psychiatry 32:1087-1093; 1975.
8. Bateman, A.; Singh, A.; Kral, T.; Solomon, S. The immune hypothalamic-pituitary-adrenal axis. Endocr. Rev. 10:92-112; 1989.
9. Bloom, B.; Asher, S.; White, S. Marital disruption as a stressor: A review an analysis. Psychol. Bull. 85:867-894; 1978.
10. Bloom, D. F.; Bloch, G. J.; Gorski, R. A. Effects of thymectomy on productive function and behaviour. Physiol. Behav. 2:291-298; 1992.
11. Bost, K. L. Hormone and neuropeptide receptor on mononuclear leucocytes. Prog. Allergy 43:68-83; 1988.
12. Britton, K. T.; et al. Activating and "anxiogenic" effects of CRF are not inhibited by blockade of the pituitary adrenal system with dexamethasone. Life Sci. 39:1281-1286; 1986.
13. Broekkamp, C.; O'Connor, W. T.; Tonnaer, J. A. D. M.; Rijk, H. W.; van Delft, A. M. L. Corticosteone, choline acetyltransferase and noradrenaline levels in olfactory bulbectomized rats in relation to changes in passive avoidancce acquisition and open field activity. Physiol. Behav. 37:429-434; 1986.
14. Cairncross, K. D.; Cox, B.; Forster, C.; Wren, A. F. Olfactory projection system, drugs and behaviour: A review. Psychopharmacology (Berlin) 102:544-548; 1978.
15. Chappell, R. B. Alterations in CRF-like immunoreactivity in discrete rat brain regions after acute and chronic stress. J. Neurosci. 6:2908-2914; 1986.
16. Cohen, J. J.; Crnic, L. S. Glucocorticoids, stress and the immune response. In: Webb, D. R., ed. Immunopharmacology and the regulation of leukocyte function. New York: Marcel Dekker; 1982:61-91.
17. Crook, T. H.; Miller, N. W. The challenge of Alzheimer's disease. Am. Psychol. 40:1245-1250; 1985.
18. Davidson, L. M.; Baum, A. Chronic stress and post traumatic stress disorders. J. Consult. Clin. Psychol. 54:303-308; 1986.
19. Dohmus, J. E.; Metz, A. Stress-mechanisms of immunosuppression. Vet. Immunol. Immunopathol. 30:89-109; 1991.
20. Dunn, A. J. Changes in cerebral dopamine, norepinephrine, and serotonin metabolism. In: van Loon, G. R.; Kvetnansky, R.; McCarty, R.; Axelrod, J., eds. Stress: Neurochemical and humoral mechanisms. New York: Gordon and Breach; 1989:79-97.
21. Dunn, A. J.; Berridge, C. B. Corticotropin-releasing factor administration elicits a stress-like activation of cerebral catecholaminergic systems. Pharmacol. Biochem. Behav. 27:685-691; 1987.
22. Evans, D. L.; Leserman, J.; Pedersen, C. A.; Golden, R. N.; Lewis, M. H.; Folds, J. A.; Ozer, H. Immune correlates of stress and depression. Psychopharmacol. Bull. 25:319-324; 1989.
23. Farrar, W. L. Evidence for the common expression of neuroendocrine hormones and cytokines in the immune and central nervous system. Brain Behav. Immunol. 2:322-327; 1988.
24. Fiore, J.; Becker, J.; Coppel, D. B. Social network interactions: A buffer or a stress? Am. J. Commun. Psychol. 11:423-429; 1983.
25. Foote, S. L.; Cha, C. I. Distribution of CRF-like immunohistochemical study. J. Comp. Neurol. 276:239-264; 1988.
26. Glaser, R.; Kiecolt-Glaser, J. K.; Stout, J. C.; Tarr, K. L.; Speicher, C. E.; Holliday, J. E. Stress-related impairments in cellular immunity. Psychiatr. Res. 16:233-239; 1985.
27. Glaser, R.; Rice, T.; Speicher, C. E.; Stout, J. C.; Kiecolt-Glaser, J. K. Stress depresses interferon production by leukocytes concomitant with a decrease in natural killer activity. Behav. Neurosci. 100:675-678; 1986.
28. Gorka, Z.; Earley, B.; Leonard, B. E. Effect of bilateral olfactory bulbectomy in the rat, alone or in combination with antidepressants, on the learned immobility model of depression. Neuropsychobiology 13:26-30; 1985.
29. Healy, D.; Calvin, J.; Whitehouse, A. M.; White, W.; Wilton-Cox, H.; Thedorou, J. M. Alpha-1-acid glycoprotein in major depressive and eating disorders. J. Affect. Disord. 2:13-20; 1991.
30. Howard, J. L.; Soroko, F. E.; Cooper, B. R. Empirical behavioural models of depression, with emphasis on tetrabenazine antagonism. In: Enna, S. J.; Malick, J. B.; Richelson, E., eds. Antidepressants: Neurochemical, behavioural and clinical perspectives. New York: Raven Press; 1981:107-120.
31. Institute of Medicine. Behavioural influences on the endocrine and immune systems. Washington, DC: National Academy Press; 1989.
32. Jain, R.; Zwickler, D.; Hollander, C. S.; Brand, H.; Saperstein, A.; Hutchinson, B.; Brown, C.; Audhya, T. Corticotrophin-releasing factor modulates the immune response to stress in the rats. Endocrinology 128:1329-1336; 1991.
33. Jankovic, B. D. Neuroimmunomodulation: Facts and dilemmas. Immunol. Lett. 21:101-118; 1989.
34. Katila, H.; Rimon, R.; Cantell, K.; Appelberg, B.; Nikkila, H. Interferon production in acute psychiatric disorder. Kurstak, H., ed. Psychiatr. Biol. Fact. 16:191-196; 1991.
35. Kelly, J. The olfactory bulbectomized rat as a model of depression: Biochemical, behavioural and pharmacological correlates. Ph.D. Thesis, Department of Pharmacology, University College, Galway, Ireland; 1991.
36. Kendall, M. D.; Shawaf, A. A. Innervation of the rat thymus gland. Brain Behav. Immunol. 5:9-28; 1991.
37. Kiecolt-Glaser, J. K.; Garner, W.; Speicher, C. E.; Penn, G.; Glaser, R. Psychosocial modifiers of immune competence in medical students. Psychosom. Med. 46:7-14; 1984.
38. Kiecolt-Glaser, T. K.; Fisher, L.; Ogrocki, P.; Stont, J. C.; Speicher, C. E.; Glaser, R. Marital quality, marital disruption and immune function. Psychosom. Med. 49:13-34; 1987.
39. Kiecolt-Glaser, J. K.; Glaser, R. Methodological issues in behavioural immunology research in humans. Brain Behav. Immunol. 2:67-78; 1988.
40. Kronfol, Z.; House, J. D. Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls. Acta. Psychiatr. Scand. 80:142-147; 1989.
41. Lavicky, J.; Dunn, A. Corticotrophin-releasing factor stimulates catecholamine release in hypothalamus and prefrontal cortex in freely moving rats as assessed by microdialysis. J. Neurochem. 60:602-612; 1993.
42. Leake, A.; Perry, E. K.; Perry, A. F.; Ferrier, I. N. Cortical concentrations of corticotropin-releasing hormone and its receptor in Alzheimer type dementia and major depression. Biol. Psychiatry 28:603-608; 1990.
43. Lee, E. H.; Tang, Y. P.; Chai, C. Y. Stress and corticotropin-releasing factor potentiate center region activity in rat or mice in an open field. Psychopharmacology (Berlin) 93:320-323; 1987.
44. Leonard, B. E. From animals to man: Advantages, problems and pitfalls of animal models in psychopharmacology. Hum. Psychopharmacol. Measures Methods 2:23-66; 1989.
45. Leonard, B. E. Stress and the immune system: immunological aspects of depressive illness. Int. Rev. Psychiatry 2:321-330; 1990.
46. Liposits, Z. S.; Paull, W. K. Association of dopaminergic fibers with corticotropin releasing hormone (CRH) synthesizing neurons in the paraventricular nuceus of the rat hypothalamus. Histochemistry 93:119-127; 1989.
47. Lugo, D. L.; Chen, S. C.; Hall, A. K.; Ziai, R.; Hempstead, J. L.; Morgan, J. I. Developmental regulation of beta-thymosins in the rat central nervous system. J. Neurochem. 56:457-461; 1991.
48. Maes, M.; Planken, V. D.; Stevens, W. J.; Peeters, L. S.; DeClerck, L. S.; Bridts, C. H.; Schotte, C.; Csyns, P. Leukocytosis, monocytosis and neutrophilia: Hallmarks of severe depression. J. Psychiatr. Res. 26:125-134; 1992.
49. Maes, M.; Scharpe, S.; van Grottel, L.; Uyttenbroeck, W.; Cooreman, W.; Cosyns, P.; Suy, E. Higher alpha-1-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding protein plasma levels during depression: Further evidence for the existence of an acute phase response. J. Affect. Disord. 24:183-192; 1992.
50. McAdams, C.; Leonard, B. E. Neutrophil and monocyte phagocytosis in depressed patients. Prog. Neuropsychopharmacol. 17: 971-984; 1993.
51. Monjan, A. A.; Collector, M. I. Stress-induced modulation of immune response. Science 196:307-308; 1977.
52. Musha, M.; Tanaka, F.; Ohuti, J. Psychoses in three cases with myasthenia-gravis and thymoma: Proposal of a paraneoplastic autoimmune neuropsychiatrie syndrome. Tohoku J. Exp. Med. 169:335-344; 1993.
53. Nathan, C. F. Secretory products of macrophages. J. Clin. Invest. 79:319-324; 1987.
54. Nemeroff, C. B.; Bissette, G.; Akil, H.; Fink, M. Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Br. J. Psychiatry 158:59-63; 1991.
55. O'Neill, B.; O'Connor, W. T.; Leonard, B. E. Depressed neutrophil phagocytosis in the rat following olfactory bulbectomy reversed by chronic desipramine treatment. Med. Sci. Res. 15:267-268; 1987.
56. O'Neill, B.; Leonard, B. E. Abnormal zymosan-induced neutrophil chemiluminescence as a marker of depression. J. Affect. Disord. 19:265-272; 1990.
57. Rinner, I.; Schaunstein, K.; Mangge, H.; Porta, S.; Kvetnansky, R. Opposite effects of severe stress on in vivo activation of rat peripheral blood lymphocytes. Brain. Behav. Immunol. 6:130-140; 1992.
58. Rivier, C. L.; Plotsky, P. M. Mediation by corticotropin-releasing factor (CRF) of adenohypophysial hormone secretion. Annu. Rev. Physiol. 48:475-494; 1986.
59. Saffran, M.; Schaly, A. V. The release of corticotropin by anterior pituitary tissue in vivo. Can. J. Biochem. Physiol. 33:408-415; 1955.
60. Schleifer, S. J.; Keller, S. E.; Camerino, M.; Thornton, J. C.; Stein, M. Suppression of lymphocyte stimulation following bereavement. JAMA 250(3):372-377; 1983.
61. Sherman, J. E.; Kalin, N. H. ICV CRH potently affects behaviour without antinociceptive responding. Life Sci. 39:433-441; 986.
62. Smith, R. S. The macrophage theory of depression. Med. Hypotheses 35:298-306; 1991.
63. Song, C.; Bao, S. The relationship between catecholamine and thymopeptides in ageing brain. J. Gerontol. 17:370-372; 1991.
64. Song, C.; Kelly, J.; Leonard, B. E. Is leucocyte adhesiveness/aggregation also a stress marker in the olfactory bulbectomized rats? Stress Med. 9:255-258; 1993.
65. Song, C.; Kelly, J. P.; Leonard, B. E. The effect of stressful behavioural exposure on endocrine and immune parameters in the rat. Stress Med. 10:239-245; 1994.
66. Song, C.; Leonard, B. E. Behavioural, neurochemical and immunological response to CRF administration: Is CRF a central mediator in stress and depression? Proc. NY Acad. Sci. 1966 (in press).
67. Stein, M.; Miller, A. H.; Trestman, R. L. Depression and the immune system. In: Ader, R.; Felton, D. L.; Cohen, N., eds. Psychoneuroimmunology. 2nd ed. New York: Academic Press; 1991:897-929.
68. Strasbaugh, H.; Irwin, J. Central corticotrophin-releasing hormone reduces cellular immunity. Brain Behav. Immunol. 6:11-17; 1992.
69. Van Riezen, H.; Leonard, B. E. Effects of psychotropic drugs on the behaviour and neurochemistry of olfactory bulbectomized rats. Pharmacol. Ther. 47:21-34; 1990.
70. Weiss, J. M.; Goodman, P. A.; Losito, B. G.; Corrigan, S.; Charry, J. M.; Bailey, W. H. Behavioural depression produced by an uncontrollable stressor: Relationship to noreprinephrine, dopamine, and serotonin levels in various regions of rat brain. Brain Res. Rev. 3:167-205; 1981.
71. Weisse, C. S. Depression and immunocompetence: A review of the literature. Psychol. Bull. 111:475-487; 1992.
72. Willner, P. Validating criteria for animal models of human mental disorders: Learned helplessness as a paradigm case. Prog. Neuropsychopharmacol. Biol. Psychiatry 10:677-690.; 1986.
73. Willner, P. Animal models of depression: An overview. Pharmacol. Ther. 45:425-455; 1990.
74. Zirbes, T.; Novotny, G. E. Quantification of thymic innervation in juvenile and aged rats. Acta Anat. 145:283-288; 1992.