Inhibition of aromatase activity and growth suppression by 4-methoxy-4-androstene-3,17-dione in an androgen sensitive human prostatic carcinoma cell line

Cancer Letters

Volumn 101, Issue 2, 1996, Pages 143-148

  Block, Janice L ^a   Block, Norman L ^a   Lokeshwar, Bal L ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Androgens; Aromatase; Growth suppression; Prostate cancer

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITOR; ESTRADIOL; FORMESTANE; TESTOSTERONE;

ANTINEOPLASTIC ACTIVITY; AROMATIZATION; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; ENZYME INHIBITION; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; PROSTATE CARCINOMA;

EID: 0029930287     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04127-4     Document Type: Article

References (17)

1. Brodie, A.M.H., Banks, P.K., Inkster, S.E., Sonj, C. and Koos, R.D. (1990) Aromatase and other inhibitors in breast and prostatic cancer. J. Steroid Biochem. Mol. Biol., 37, 1043-1048.
2. Brodie, A.M.H., Garrett, W.M., Hendrickson, J.R., Tsai-Morris, C.-H., Marcotte, P.A. and Robinson, C.H. (1981) Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo. Steroids, 38, 693-702.
3. Brodie, A.M.H., and Longcope, C. (1980) Inhibition of peripheral aromatization by aromatase inhibitors, 4-hydroxy-and 4-acetoxyandrostene-3,17-dione. Endocrinology, 106, 21-27.
4. Chen, H., Kirschenbaum, A., Mandeli, J. and Hollander, V.P. (1992) The effect of dihydrotestosterone and culture conditions on proliferation of the human prostatic cancer cell line LNCaP. Steroids, 57, 269-275.
5. Davies, J.H., Dowsett, M., Jacobs, S., Coombes, R.C., Hedley, A. and Shearer, R.J. (1992) Aromatase inhibition: 4-hydroxyandrostenedione (4-OHA, CGP 32349) in advanced prostatic cancer. Br. J. Cancer, 66, 139-142.
6. Di Salle, E., Giudici, D., Ornati, G., Briatico, G., D'Alessio, R., Villa, V. and Lombardi, P. (1990) 4-Aminoandrostenedione derivatives: a novel class of irreversible aromatase inhibitors. J. Steroid Biochem. Mol. Biol., 37, 369-374.
7. Ghanadian, R., Puah, C.M. and O'Donoghue, E.P. (1979) Serum testosterone and dihydrotestosterone in carcinoma of the prostate. Br. J. Cancer, 39, 696-699.
8. 1. Cancer Res., 52, 5821-5825.
9. Marsh, D.A., Brodie, H.J., Garrett, W., Tsai-Morris, C.-H. and Brodie, A.M.H. (1985) Aromatase inhibitors: synthesis and biological activity of androstenedione derivatives. J. Med. Chem., 28, 788-795.
10. Matzkin, H. and Soloway, M.S. (1992) Immunohistochemical evidence of the existence and localization of aromatase in human prostatic tissues. Prostate, 21, 309-314.
11. Product data sheet for HyClone Laboratories, Inc. (1991) Catalogue No. CO-A-11A4-L.
12. Schuurmans, A.L.G., Bolt, J. and Mulder, E. (1988) Androgens stimulate both growth rate and epidermal growth factor receptor activity of the human prostate tumor cell LNCaP. Prostate, 12, 55-63.
13. Smith, C.B., Masters, J.R., Metcalfe, S.A. and Ghanadian, R. (1983) Androgen metabolism by human prostate tumors. Eur. J. Cancer Clin. Oncol., 19, 929-934.
14. Stone, N.N., Fair, W.R. and Fishman, J. (1986) Estrogen formation in human prostatic tissue from patients with and without benign prostatic hyperplasia. Prostate, 9, 311-318.
15. Thompson, E.A. and Siiteri, P.K. (1974) Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsome during aromatization of androstenedione. J. Biol. Chem., 249, 5364-5372.
16. Veldscholte, J.U., Voorhorst-Ogink, M.M., Bolt-de Vries, J.B., van Rooij, H.C.J., Trapman, J. and Eppo, M. (1990) Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: high affinity for progestagenic and estrogenic steroids. Biochim. Biophys. Acta, 1052, 187-194.
17. Zimniski, S.J., Brandt, M.E., Meiner, Covey, D.F. and Puett, D. (1985) Inhibition of Leydig tumor cell steroidogenesis by 10-propargylester-4ene-3,17-dione, an irreversible aromatase inhibitor. Cancer Res., 45, 4883-4889.