Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 4, 1996, Pages 473-476

  Gossett, Lynn S ^a   Habeck, Lillian L ^a   Gates, Susan B ^a   Andis, Sherri L ^a   Worzalla, John F ^a   Schultz, Richard M ^a   Mendelsohn, Laurane G ^a   Kohler, William ^b   Ratnam, Manohar ^b   Grindey, Gerald B ^a   Shih, Chuan ^a  

^a ELI LILLY AND COMPANY   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; EDATREXATE; ENZYME INHIBITOR; GLUTAMIC ACID DERIVATIVE; LOMETREXOL; METHOTREXATE; PEMETREXED;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HUMAN; HUMAN CELL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0029930194     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00053-4     Document Type: Article

References (8)

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2. Taylor, E. C.; Kuhnt, D.; Shih, C.; Rinzel, S. M.; Grindey, G. B.; Barredo, J.; Jannatipour, M.; Moran, R. G. J. Med. Chem. 1992, 35, 4450.
3. (a) Shih, C.; Gossett, L. S.; Heterocycles, 1993, 35, 825.
4. (b) Shih, C; Hu, Y.; Gossett, L. S.; Habeck, L. L.; Mendelsohn, L. G.; Grindey, G. B. Bioorg. Med. Chem. Lett. 1993, 3, 2657.
5. (a) Taylor, E. C.; Harrington, P. M.; Shih, C. Heterocycles, 1989, 28, 1169.
6. (b) Part of this work was presented as an abstract at the 86th Annual American Association for Cancer Research Meeting in Toronto, Ontario, Canada, March 18-22, 1995.
7. Seela, F.; Steker, H.; Driller, H.; Bindig, U. Liebigs Ann. Chem. 1987, 15.
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