Pathogenesis of schizophrenic delusions and hallucinations: A neural model

Schizophrenia Bulletin

Volumn 22, Issue 1, 1996, Pages 105-123

  Ruppin, Eytan ^a   Reggia, James A ^b   Horn, David ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COGNITION; DELUSION; FRONTAL LOBE; HALLUCINATION; MODEL; NERVE PROJECTION; PATHOGENESIS; PRIORITY JOURNAL; SCHIZOPHRENIA;

EID: 0029930103     PISSN: 05867614     EISSN: None     Source Type: Journal    
DOI: 10.1093/schbul/22.1.105     Document Type: Article

References (57)

1. Alvarez, P., and Squire, L.R. Memory consolidation and the medial temporal lobe: A simple network model. Proceedings of the National Academy of Science of the United States of America, 91:7041-7045, 1994.
2. Amit, D.J. Modeling Brain Function: The World of Attractor Neural Networks. Cambridge, England: Cambridge University Press, 1989.
3. Armentrout, S.; Reggia, J.; and Weinrich, M. A neural model of cortical map reorganization following a focal lesion. Artificial Intelligence in Medicine, 6:383-400, 1994.
4. Calabresi, P.; Maj, R.; Pisani, A.; Mercuri, N.B.; and Bernardi, G. Long-term synaptic depression in the striatum: Physiological and pharmacological characterization. Journal of Neuroscience, 12(11):4224-4233, 1992.
5. Carpenter, W.T., Jr., and Buchanan, R.W. Schizophrenia. New England Journal of Medicine, 330(10):681-690, 1994.
6. Chaturvedi, S.K., and Sinha, V.D. Recurrence of hallucinations in consecutive episodes of schizophrenia and affective disorder. Schizophrenia Research, 3:103-106, 1990.
7. Cohen, J.D., and Servan-Schreiber, D. Context, cortex, and dopamine: A connectionist approach to behavior and biology in schizophrenia. Psychological Review, 99(1):45-77, 1992.
8. Dell, G. A spreading-activation theory of retrieval and sentence production. Psychological Review, 93:283-321, 1986.
9. Eccles, J.C. The modular operation of the cerebral neocortex considered as the material basis of mental events. Neuroscience, 6:1839-1855, 1981.
10. Frey, U.; Schroeder, H.; and Matthies, H. Dopaminergic antagonists prevent long-term maintenance of posttetanic LTP in the CA1 region of rat hippocampal slices. Brain Research, 522(1):69-75, 1990.
11. Friedman, H.R.; Janas, J.D.; and Goldman-Rakic, P.S. Enhancement of metabolic activity in the diencephalon of monkeys performing working memory tasks: A 2-deoxyglucose study in behaving rhesus monkeys. Journal of Cognitive Neuroscience, 2(1):18-31, 1990.
12. Frith, C. In what context is latent inhibition relevant to the symptoms of schizophrenia? Behavioral and Brain Sciences, 14(1):28, 1991.
13. Fuster, J.M., and Jervey, J.P. Neuronal firing in the inferotemporal cortex of the monkey in a visual memory task. Journal of Neuroscience, 2(3):361-375, 1982.
14. Globus, G.G., and Arpaia, J.P. Psychiatry and the new dynamics. Biological Psychiatry, 35:352-364, 1994.
15. Goldman P.S., and Nauta, W.J.H. Columnar distribution of corticocortical fibers in the frontal, association, limbic, and motor cortex of the developing rhesus monkey. Brain Research, 122:393-413, 1977.
16. Goldman-Rakic, P.S. Circuitry of primate prefrontal cortex and regulation of behavior by representational memory: In: Plum, F., and Mountcastle, V., eds. Handbook of Physiology. Bethesda, MD: American Physiological Society, 1987. pp. 373-117.
17. Goldman-Rakic, P.S. Prefrontal cortical dysfunction in schizophrenia: The relevance of working memory. In: Carroll, B.J., and Barrett, J.E., eds. Psychopathology and the Brain. New York, NY: Raven Press, 1991. pp. 1-23.
18. Gray, J.A.; Feldon, J.; Rawlins, J.N.P.; Hemsley, D.R.; and Smith, A.D. The neuropsychology of schizophrenia. Behavioral and Brain Sciences, 14:1-84, 1991.
19. Hasselmo, M.E. Runaway synaptic modification in models of the cortex: Implications for Alzheimer's disease. Neural Networks, 7(1):13-40, 1994.
20. Heit, G.; Smith, M.E.; and Halgren, E. Neural encoding of individual words and faces by the human hippocampus and amygdala. Nature, 333:773-775, 1988.
21. Herrmann, M.; Ruppin, E.; and Usher, M. A neural model of the dynamic activation of memory. Biological Cybernetics, 68:455-463, 1993.
22. Hinton, G.E., and Shallice, T. Lesioning an attractor network: Investigations of acquired dyslexia. Psychological Review, 98(1):74-95, 1991.
23. Hoffman, R.E. Verbal hallucinations and language production processes in schizophrenia. Behavioral and Brain Sciences, 9:503-548, 1986.
24. Hoffman, R.E. Computer simulations of neural information processing and the schizophrenia-mania dichotomy. Archives of General Psychiatry, 44:178-188, 1987.
25. Hoffman, R.E., and Dobscha, S.K. Cortical pruning and the development of schizophrenia: A computer model. Schizophrenia Bulletin, 15(3):477-490, 1989.
26. Hoffman, R.E., and McGlashan, T.H. Parallel distributed processing and the emergence of schizophrenic symptoms. Schizophrenia Bulletin, 19(1):119-140, 1993.
27. Hoffman, R.E., and Rapaport, J.A. A psycholinguistic study of auditory/verbal hallucinations: Preliminary findings. In: David, A., and Cutting, J., eds. The Neuropsychology of Schizophrenia. Hillsdale, NJ: Lawrence Erlbaum Associates, 1994. pp. 255-267.
28. Hopfield, J.J. Neural networks and physical systems with emergent collective abilities. Proceedings of the National Academy of Sciences of the United States of America, 79:2554-2558, 1982.
29. Horn, D., and Ruppin, E. Compensatory mechanisms in an attractor neural network model of schizophrenia. Neural Computation, 7(1):182-205, 1995.
30. Horn, D., and Ruppin, E. "Synaptic Maintenance in Associative Memory Networks." In preparation.
31. Horn, D.; Ruppin, E.; Usher, M.; and Herrmann, M. Neural network modeling of memory deterioration in Alzheimer's disease. Neural Computation, 5:736-749, 1993.
32. Hyde, T.M.; Ziegler, J.C.; and Weinberger, D.R. Psychiatric disturbances in metachromatic leukodystrophy: Insights into the neurobiology of psychosis. Archives of Neurology, 49:401-406, 1992.
33. Javitt, D.C., and Zukin, S.R. Mechanisms of phenylcyclidine (PCP)-N methyl-D-aspartate (NMDA) receptor interaction: Implications for schizophrenia. In: Tamminga, C.A., and Schulz, S.C., eds. Advances in Neuropsychiatry and Psychopharmacology. New York, NY: Raven Press, 1993. pp. 13-19.
34. Jin, Y.; Potkin, S.G.; Rice, D.; Sramek, J.; Costa, J.; Isenhart, R.; Heh, C.; and Steadman, C.A. Abnormal EEG responses to photic stimulation in schizophrenic patients. Schizophrenia Bulletin, 16(4):627-634, 1990.
35. Kaplan, H.I., and Sadock, B.J. Synopsis of Psychiatry. Baltimore, MD: Williams & Wilkins Company, 1991.
36. Karler, R.; Calder, L.D.; and Turkanis, S.A. Dnqx blockade of amphetamine behavioral sensitization. Brain Research, 552:295-300, 1991.
37. Mesulam, M.M. Schizophrenia and the brain. New England Journal of Medicine, 322(12):842-845, 1990.
38. Miyashita, Y., and Chang, H.S. Neuronal correlate of pictorial short-term memory in the primate temporal cortex. Nature, 331:68-71, 1988.
39. Monowitz, P.; Kling, A.; and Kohn, H. Clinical course of adult metachromatic leukodystrophy presenting as schizophrenia: A report of two living cases in siblings, Journal of Nervous and Mental Disease, 166(7):500-506, 1978.
40. Mountcastle, V.B. An organizing principle for cerebral function: The unit module and the distributed system. In: Schmitt, F.O., and Worden, F.G., eds. The Neurosciences: Fourth Study Program. Cambridge, MA: MIT Press, 1979. pp. 21-42.
41. Nauta, W.J.H., and Domesick, V.B. Neural associations of the limbic system. Neural Basis of Behavior, 10:175-206, 1982.
42. 31P nuclear magnetic resonance spectroscopy: Neurodevelopment and schizophrenia. Schizophrenia Bulletin, 19(1):35-53, 1993.
43. Pettegrew, J.W.; Keshavan, M.S.; Panchalingam, K.; Strychor, S.; Kaplan, D.B.; Trerta, M.G.; and Allan, M. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics: A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic spectroscopy. Archives of General Psychiatry, 48:563-568, 1991.
44. Reggia, J.A.; Berndt, R.S.; and D'Autrechy, L. Connectionist models in neuropsychology. In: Boller, F., and Grafman, J., eds. Handbook of Neuropsychology. Vol. 9. Amsterdam, The Netherlands: Elsevier Science Publishers, 1994. pp. 297-333.
45. Reggia, J.A.; Marsland, P.; and Berndt, R.S. Competitive dynamics in a dual-route connectionist model of print-to-sound transformation. Complex Systems, 2:509-547, 1988.
46. Ruppin, E. Neural modeling of psychiatric disorders. Network: Computation in Neural Systems, 6:1-22, 1995.
47. Ruppin, E., and Reggia, J.A. A neural model of memory impairment in diffuse cerebral atrophy. British Journal of Psychiatry, 166(1):19-28, 1995.
48. Sakay, K., and Miyashita, Y. Neural organization of the long-term memory of pair associates. Nature, 354:152-159, 1990.
49. Seeman, P. Schizophrenia as a brain disease: The dopamine receptor story. Archives of Neurology, 50:1093-1095, 1993.
50. Servan-Schreiber, D.; Printz, H.; and Cohen, J.D. A network model of cathecholamine effects: Gain, signal-to-noise ratio, and behavior. Science, 249:892-895, 1990.
51. Sherman, A.D.; Davidson, A.T.; Baruah, S.; Hedgewood, T.S.; and Waziri, R. Evidence of glutamatergic deficiency in schizophrenia. Neuroscience Letters, 121:77-90, 1991.
52. Squire, L.R. Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans. Psychological Review, 99:195-231, 1992.
53. Stevens, J.R. Abnormal reinnervation as a basis for schizophrenia: A hypothesis. Archives of General Psychiatry, 49:238-243, 1992.
54. Tsodyks, M.V., and Feigelman, M.V. The enhanced storage capacity in neural networks with low activity level. Europhysics Letters, 6:101-105, 1988.
55. Weinberger, D,R. Anteromedial temporal-prefrontal connectivity: A functional neuroanatomical system implicated in schizophrenia. In: Carroll, B.J., and Barrett, J.E., eds. Psychopathology and the Brain. New York, NY: Raven Press, 1991. pp. 25-43.
56. Williamson, P.C. Schizophrenia as a brain disease. Archives of Neurology, 50:1096-1097, 1993.
57. Wilson, F.A.W.; Scalaidhe, S.P.O.; and Goldman-Rakic, P.S. Dissociation of object and spatial processing domains in primate prefrontal cortex. Science, 260:1955-1958, 1993.