Pharmacokinetics of pyropheophorbide-a-hexyl ether in the dog

Lasers in Surgery and Medicine

Volumn 18, Issue 4, 1996, Pages 406-409

  Payne, John T ^a   McCaw, Dudley L ^a   Casteel, Stan W ^a   Frazier, Donita ^c   Rogers, Kevin ^b   Tompson, Robert V ^b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

pharmacokinetics; pheophorbide; photodynamic therapy; photosensitizer

Indexed keywords

PHOTOSENSITIZING AGENT; PYROPHEOPHORBIDE A HEXYL ETHER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL;

ANIMALS; CHLOROPHYLL; DOGS; FEMALE; HALF-LIFE; MALE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 0029930009     PISSN: 01968092     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9101(1996)18:4<406::AID-LSM10>3.0.CO;2-1     Document Type: Article

References (8)

1. Weishaupt KR, Gomer CJ, Dougherty TJ. Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor. Cancer Res 1976; 7:2326-2329.
2. Ash DV, Brown SB. New drugs and future developments in photodynamic therapy. Eur J Cancer 1993; 29A:1781-1783.
3. Bellnier DA, Henderson BW, Pandey RK, Potter WR, Dougherty TJ. Murine pharmacokinetics and antitumor efficacy of the photodynamic sensitizer 2-[hexyloxyethyl]-2-devinyl pyropheophorbide-a. J Photochem Photobiol B 1993; 20:55-61.
4. Sumlin AB, Dougherty TJ, Smith KM. Structure/activity relationship among photosensitizers related to pheophorbide and bacteriopheophorbide. Bioorg Med Chem Lett 1992; 2:491-496.
5. Bellnier DA, HO Y-K, Pandey RK, Missert JR, Dougherty TJ. Distribution and elimination of Photofrin II in mice. Photochem Photobiol 1989; 50:221-228.
6. Cheli R, Addis F, Mortellaro CM, Fonda D, Cubeddu R. Photodynamic therapy of spontaneous animal tumors using the active component of hematoporphyrin derivative (DHE) as photosensitizing drug: Clinical results. Cancer Lett 1987; 38:101-105.
7. Roberts WG, Klein MK, Loomis M, Weldy S, Berns MW. Photodynamic therapy of spontaneous cancers in felines, canines, and snakes with chloro-aluminum sulfonated phthalocyanine. J Natl Cancer Inst 1991; 83:18-23.
8. Dougherty TJ, Thoma RE, Boyle DG, Weishaupt KR. Interstitial photoradiation therapy for primary solid tumors in pet cats and dogs. Cancer Res 1981; 41:401-404.