Three distinct components of the negative inotropic action of lidocaine in dog Purkinje fiber

General Pharmacology

Volumn 27, Issue 1, 1996, Pages 69-71

  Pankucsi, Csaba ^a   Varró, András ^b   Nánási, Péter P ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Action potential duration; Anti arrhythmic drugs; Cardiac contractility; Electrophysiology; Negative inotropy; Sodium channels

Indexed keywords

LIDOCAINE; NICORANDIL; SODIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE POTENTIAL; HEART PACING; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER;

EID: 0029929353     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)00089-5     Document Type: Article

References (16)

1. Attwell D., Cohen I., Eisner D., Ohba M. and Ojeda C. (1979) The steady-state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres. Pflügers. Arch. 379, 137-142.
2. Bigger J. T. and Mandel W. J. (1970) Effects of lidocaine on electrophysiological properties of ventricular muscle and Purkinje fibers. J. clin. Invest. 49, 63-77.
3. Boyett M. R. and Fedida D. (1984) Changes in the electrical activity of dog cardiac Purkinje fibres at high heart rates. J. Physiol. 350, 361-391.
4. Coraboeuf E., Deraubaix E. and Coulombe A. (1979) Effect of tetrodotoxin on cardiac action potentials of the conducting system in the dog heart. Am. J. Physiol. 236, 561-567.
5. Eisner D. A., Lederer W. J. and Sheu S.-S. (1983) The role of intracellular sodium activity in the anti-arrhythmic action of local anaesthetics in sheep Purkinje fibres. J. Physiol. 340, 239-257.
6. Grant A. O., Dietz M. A., Gilliam F. R. and Starmer C. F. (1989) Blockade of cardiac sodium channels by lidocaine. Circ. Res. 65, 1247-1262.
7. Hammermeister K. E., Boerth R. C. and Warbasse J. R. (1972) The comparable inotropic effects of six clinically used antiarrhythmic agents. Am. Heart J. 84, 643-652.
8. Hondeghem L. M. and Katzung B. G. (1977) Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim. biophys. Acta 472, 373-398.
9. Horackova M. and Vassort G. (1979) Sodium-calcium exchange in regulation of cardiac contractility. Evidence for an electrogenic, voltage-dependent mechanism. J. Gen. Physiol. 73, 403-424.
10. Imanishi S., Arita M., Kiyosue T. and Aomine M. (1983) Effects of SG-75 (nicorandil) on electrical activity of canine cardiac Purkinje fibers: possible increase in potassium conductance. J. Pharmacol. exp. Ther. 225, 198-205.
11. Kakei M., Yoshinaga M., Saito K. and Tanaka H. (1986) The potassium current activated by 2-nicotinamidoethyl nitrate (nicorandil) in single ventricular cells of guinea pigs. Proc. R. Soc. Land. B. 229, 331-343.
12. Sheu S.-S. and Lederer W. J. (1985) Lidocaine's negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity. Circ. Res. 57, 578-590.
13. max of action potential upstroke in canine cardiac Purkinje fibers. J. cardiovasc. Pharmacol. 7, 482-492.
14. Varró A., Nakaya Y., Elharrar V. and Surawicz B. (1986) Effect of antiarrhythmic drugs on the cycle length-dependent action potential duration in dog Purkinje and ventricular muscle fibers. J. cardiovasc. Pharmacol. 8, 178-185.
15. Vaughan Williams E. M. (1984) Subgroups of class 1 antiarrhythmic drugs. Eur. Heart J. 5, 96-98.
16. Wasserstrom J. A. and Salata J. J. (1988) Basis for tetrodotoxin and lidocaine effects on action potentials in dog ventricular myocytes. Am. J. Physiol. 254, H1157-H1166.