Screening of traditional medicines for their inhibitory activity against HIV-1 protease

Phytotherapy Research

Volumn 10, Issue 3, 1996, Pages 207-210

  Xu, Hong Xi ^a   Wan, Min ^a   Loh, Boon Nee ^a   Kon, Oi Lian ^a   Chow, Peng Wai ^a   Sim, Keng Yeow ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Aqueous extracts; Fluorogenic assay; Inhibition of HIV 1 protease; Traditional medicines

Indexed keywords

ABOCASIA ODORA EXTRACT; ALPINIA OFFICINARUM EXTRACT; ANDROGRAPHIS PANICULATA EXTRACT; ANEMARRHENA ASPHODELOIDES EXTRACT; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ARTEMISIA CAPILLARIS EXTRACT; ASTER TATARICUS EXTRACT; ASTRAGALUS MEMBRANACEUS EXTRACT; ATRACTYLODES EXTRACT; ATRACTYLODES OVATA EXTRACT; BELAMCANDA CHINENSIS EXTRACT; BRAINIA INSIGNIS EXTRACT; BRUCEA JAVANICA EXTRACT; CANNABIS; CASSIA FISTULA EXTRACT; CHRYSANTHEMUM MORIFOLIUM EXTRACT; CIMICIFUGA HERACLEIFOLIA EXTRACT; CLEMATIS CHINENSIS EXTRACT; COPTIS CHINENSIS EXTRACT; CYPERUS ROTUNDUS EXTRACT; MAGNOLIA FARGESII EXTRACT; PAEONIA SUFFRUTICOSA EXTRACT; PHELLODENDRON AMURENSE EXTRACT; PLANT EXTRACT; PROTEINASE; PROTEINASE INHIBITOR; TERMINALIA CHEBULA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS ENZYME;

ARTEMISIA PRINCEPS; ARTICLE; CHINA; CONTROLLED STUDY; DRUG CONCENTRATION; DRUG SCREENING; FLUORESCENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; INDONESIA; JAPAN; NONHUMAN; TRADITIONAL MEDICINE;

EID: 0029929056     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(199605)10:3<207::AID-PTR812>3.0.CO;2-U     Document Type: Article

References (14)

1. Barre, S. F., Chermann, J. C., Rey, F. et al., (1983). Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220, 868-871.
2. Fukuchi, K., Sakagami, H., Okuda. T. et al. (1989). Inhibition of herpes simplex virus infection by tannins and related compounds. Antiviral Res. 11, 285-298.
3. Grampurohit, N. D. (1986). Gallic acid from myrobalans. Indian J. Nat Prod. 2(2). 10-11.
4. Lin, T. C., Nonaka, G., Nishioka, I., and Ho, F. C. (1990). Tannins and related compounds: CII. Structures of terchebulin, an ellagitannin having a novel tetraphenylcarboxylic acid (terchebulic acid) moiety, and biogenetically related tannins from Terminalia chebula Retz. Chem. Pharm. Bull 38(11), 3004-3008.
5. Matayoshi, E. D., Wang, G. T., Krafft, G. A., and Erickson, J. W. (1990). Novel fluorogenic substrates for assaying retroviral proteolytic activity by resonance energy transfer. Science 247, 954-958,
6. McQuade, T. J., Tomasselli, A. G., Liu, L et al., (1990). A. synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science 247, 454-456.
7. Mitsuya, H., Yarchoan, R., and Broder, S. (1990). Molecular targets for AIDS therapy fluorogenic assay. Science 249, 1533-1544.
8. Popovic, M., Sarngadharan, M. G., Read, E., and Gallo, R. C. (1984). Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224, 497-500.
9. Ross, I. B., Martin, J. S., and David, P. F. (1992). Flavones are inhibitors of HIV-1 preoteinase. Biochem. Biophys. Res. Commun. 188(2), 631-637.
10. Seelmeier, S., Schmidt, H., Turk, V., and Von der Helm, K. (1988). Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc. Natl Acad. Sci. USA 85, 6612-6616.
11. Wang, G. T., Huffker, J. A., Matayoshi, E., and Krafft, G. A. (1990). Design and synthesis of novel fluorogenic substrates for assaying HIV protease. Tetrahedron Lett. 165, 6493-6496.
12. Wong, S. F., and Gallo, R. C. (1985). Human T-lymphotropic retroviruses. Nature (London) 317, 395-403.
13. Xu, H. X., Kadota, S., Kurokawa, M., Shiraki, K., Matsumoto, T., and Namba, T. (1993). Isolation and structure of Woodorien, a new glucoside having antiviral activity, from Woodwardia orientalis. Chem. Pharm. Bull. 41 (10), 1803-1806.
14. Xu, H. X., Kadota, S., Wang, H. et al. (1994). A new hydrolyzable tannin from Geum japonicum and its antiviral activity. Heterocycles 38(1), 167-175.