Ret protein in the human fetal rectum

Journal of Pediatric Surgery

Volumn 31, Issue 4, 1996, Pages 568-571

  Tam, P K H ^a   Gould, S J ^b   Martucciello, G ^b   Biddolph, S ^b   Takahashi, M ^b   Jasonni, V ^b  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b NONE

Author keywords

enteric nervous system; Hirschsprung's disease; human embryogenesis; intestinal aganglionosis; receptor tyrosine kinase; Ret protein; RET proto oncogene

Indexed keywords

GENE PRODUCT; PROTEIN; PROTEIN TYROSINE KINASE;

CONFERENCE PAPER; ENZYME ACTIVITY; FETUS; FETUS DEVELOPMENT; HIRSCHSPRUNG DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NERVE CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; RECTUM;

EID: 0029928693     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3468(96)90498-4     Document Type: Conference Paper

References (25)

1. Furness JB, Costa M: The Enteric Nervous System (ed 1). Edinburgh, UK, Churchill Livingstone, 1987, pp 1-5
2. Martucciello G, Bicocchi MP, Dodero P, et al: Total colonic aganglionosis associated with interstitial deletion of the long arm of chromosome 10. Pediatr Surg Int 7:308-310, 1992
3. Fewtrell MS, Tam PKH, Thomson AH, et al: Hirschsprung's disease associated with a deletion of chromosome 10 (Q 11,2 and 21.2) - A further link with the neurocristopathies. J Med Genet 31:325-327, 1994
4. Lyonnet S, Bolino A, Pelet A, et al: A gene for Hirschsprung's disease maps to the proximal long arm of chromosome 10. Nature Genet 4:346-350, 1993
5. Angrist M, Kauffman E, Slaugenhaupt SA, et al: A gene for Hirschsprung's disease (megacolon) in the pericentromeric region of human chromosome 10. Nature Genet 4:351-356, 1993
6. Yin L, Ceccherini I, Pasini B, et al: Close linkage with the RET proto-oncogene and deletion mutations in autosomal dominant Hirschsprung's disease. Hum Mol Genet 2:1803-1808, 1993
7. Romeo G, Ronchetto P, Yin L, et al: Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature 367:377-378, 1994
8. Edery P, Lyonnet S, Mulligan LM, et al: Mutations of the RET proto-oncogene in Hirschsprung's disease. Nature 367:378-380, 1994
9. Yin L, Barone V, Seri M, et al: Heterogeneity and low detection rate of RET mutations in Hirschsprung's disease. Eur J Hum Genet 2:272-280, 1994
10. Edery P, Pelet A, Mulligan CM, et al: Long segment and short segment familial Hirschsprung's disease: Variable clinical expression at the RET locus. J Med Genet 31:602-606, 1994
11. Takahashi M, Cooper GM: Ret transforming gene encodes a fusion protein homologous to tyrosine kinase. Mol Cell Biol 7:1378-1385, 1987
12. Takahashi M, Buna Y, Iwanoto T, et al: Cloning and expression of the Ret proto-oncogene encoding c tyrosine kinase with two potential tranasmembrane domains. Oncogene 3:571-578, 1983
13. Takahashi M, Buma T, Hiai H: Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence. Oncogene 8:805-806, 1989
14. Iwamoto T, Taniguchi M, Asai N, et al: cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the codherin superfamily. Oncogene 4:1087-1091, 1993
15. Martucciello G, Favre A, Takahashi M, et al: Immunohistochemical localization of RET protein in Hirschsprung's disease. J Pediatr Surg 30:433-436, 1995
16. Cordell JL, Falini B, Erber WN, et al: Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 32:219-229, 1984
17. Takahashi M, Buma Y, Taniguchi M: Identification of the ret proto-oncogene products in neuroblastoma and leukemic cells. Oncogene 6:297-301, 1991
18. Takahashi M, Asai N, Iwashita T, et al: Characterization of the ret proto-oncogene products expressed in mouse L cells. Oncogene 8:2928-2929, 1993
19. Molenaar JC: Pathogenetic aspects of Hirschsprung's disease. Br J Surg 82:145-147, 1995
20. Tam PKH, Lister J: Developmental profile of neuron-specific enolase in human gut and its implications in Hirschsprung's disease. Gastroenterology 90:1902-1906, 1986
21. Pachnis V, Mankoo B, Costantini F: Expression of the c Ret proto-oncogene during mouse embryogenesis. Development 19: 1005-1017, 1993
22. Tsuzuki T, Takahashi M, Asai N, et al: Spatial and temporal expression of the Ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene 10:191-198, 1995
23. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212, 1990
24. Pasini B, Borrello MG, Greco A, et al: Loss of function effect of RET mutations causing Hirschsprung's disease. Nature Genet 10:35-40, 1995
25. Santoro M: Germ-line mutations of MEN 2A and MEN2B activate RET as a dominant transforming gene by different molecular mechanisms. Science 267:381-383, 1995