Effect of acute and chronic lead exposure on the level of sulfhydryl groups in rat brain

Acta Neurobiologiae Experimentalis

Volumn 56, Issue 1, 1996, Pages 233-236

  Da̧browska Bouta, Beata ^a   Struzyńska, Lidia ^a   Rafałowska, Urszula ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

lead; lead protein interactions; SH groups

Indexed keywords

BRAIN PROTEIN; LEAD; THIOL GROUP;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN HOMOGENATE; BRAIN METABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; MALE; NEUROTOXICITY; NONHUMAN; RAT;

ANIMALS; BRAIN CHEMISTRY; LEAD; MALE; PROTEIN BINDING; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS;

EID: 0029928680     PISSN: 00651400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (11)

1. Booth R. F. G., Clark J. B. (1978) A rapid method for the preparation of relatively pure, metabolically competent synaptosomes from rat brain. Biochem. J. 176: 365-370.
2. Duval G., Fowler B. A. (1989) Preliminary purification and characterisation studies of a low molecular weight, high affinity cytosolic lead-binding protein in rat brain. Biochem. Biophys. Res. Commun. 159: 177-184.
3. Ebadi M., Swanson S. (1987) Characterisation of metallothionein-like protein in rat brain. Exp. Suppl. 52: 289-291.
4. Goering P. L. (1993) Lead-protein interaction as a basis for lead toxicity. Neurotoxicology 14: 45-60.
5. Jabłońska L., Walski M., Rafałowska U. (1994) Lead as an inductor of some morphological and functional changes in synaptosomes from rat brain. Cell. Mol. Neurobiol. 14: 701-709.
6. Legare M. E., Barhoumi R., Burghardt R. C., Tiffany-Castiglioni E. (1993) Low - level lead exposure in cultured astroglia: identification of cellular targets with fluorescent probe. Neurotoxicology 14: 267-272.
7. Lowry O. H., Rosebrought N. J., Farr A. L., Randall R. J. (1951) Protein measurements with Folin Phenol reagent. J. Biol. Chem. 193:265-275.
8. Oskarsson A., Squibb K. S., Fowler B. A. (1982) Intracellular binding of lead in the kidney: the partial isolation and characterisation of postmitochondrial lead-binding components. Biochem. Biophys. Res. Commun. 104: 290-298.
9. Sedlak J., Lindsay R. H. (1968) Estimation of total, protein-bond and non protein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25: 192-205.
10. Silbergeld E. K., Hruska R. E. (1980) Neurochemical investigations of low level lead exposure. In: Low level lead exposure: the clinical implications of current research (Ed. H.L. Needleman). Raven Press, New York, p. 135-157.
11. Struzyńska L., Rafałowska U. (1994) The effect of lead on dopamine, GABA and histidine spontaneous and KCl-dependent release from rat brain synaptosomes. Acta Neurobiol. Exp. 54: 201-207.