Affinity Maturation of a High-affinity Human Monoclonal Antibody Against the Third Hypervariable Loop of Human Immunodeficiency Virus: Use of Phage Display to Improve Affinity and Broaden Strain Reactivity

Journal of Molecular Biology

Volumn 256, Issue 1, 1996, Pages 77-88

  Thompson, Julia ^a   Pope, Tony ^a   Tung, Jwu Sheng ^b   Chan, Christine ^b   Hollis, Gregory ^b,c   Mark, George ^b   Johnson, Kevin S ^a  

^a MEDIMMUNE LTD   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c DUPONT COMPANY   (United States)

Author keywords

Affinity maturation; Antibodies to HIV; High affinity antibody; Human antibody; Phage display library

Indexed keywords

GLYCOPROTEIN GP 120; HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; OLIGONUCLEOTIDE; SYNTHETIC PEPTIDE; VIRUS PROTEIN;

ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; GERM LINE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

EID: 0029927859     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0069     Document Type: Article

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