Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine

Infection and Immunity

Volumn 64, Issue 4, 1996, Pages 1290-1298

  Takahashi, Ichiro ^a,b   Kiyono, Hiroshi ^a   Jackson, Raymond J ^a   Fujihashi, Kohtaro ^a   Staats, Herman F ^c   Hamada, Shigeyuki ^b   Clements, John D ^d   Bost, Kenneth L ^d   McGhee, Jerry R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CD3 ANTIGEN; CD4 ANTIGEN; CYTOKINE; EPITOPE; ESCHERICHIA COLI ENTEROTOXIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; PEPTIDE; VACCINE;

ANTIBODY TITER; ARTICLE; DRUG DEVELOPMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; ESCHERICHIA COLI; FEMALE; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029927750     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.4.1290-1298.1996     Document Type: Article

References (40)

1. Beagley, K. W., J. H. Eldridge, H. Kiyono, M. P. Everson, W. J. Koopman, T. Honjo, and J. R. McGhee. 1988. Recombinant IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells. J. Immunol. 141: 2035-2042
2. Belisle, B. W., E. M. Twiddy, and R. K. Holmes. 1984. Monoclonal antibodies with an expanded repertoire of specificities and potent neutralizing activity for Escherichia coli heat-labile enterotoxin. Infect. Immun. 46:759-764.
3. Black, R. E. 1993. Epidemiology of diarrheal disease: implications for control by vaccines. Vaccine 11:100-106.
4. Buchmeier, N. A., and F. Heffron. 1990. Induction of Salmonella stress proteins upon infection of macrophages. Science 248:730-732.
5. Buchmeier, N. A., and F. Heffron. 1991. Inhibition of macrophage phagosome-lysosome fusion by Salmonella typhimurium. Infect. Immun. 59:2232-2238.
6. Clements, J. D., and R. A. Finkelstein. 1979. Isolation and characterization of homogeneous heat-labile enterotoxins with high specific activity from Escherichia coli cultures. Infect. Immun. 24:760-769.
7. Clements, J. D., D. C. Flint, R. F. Engert, and F. A. Klipstein. 1983. Cloning and molecular characterization of the B subunit of Escherichia coli heat-labile enterotoxin. Infect. Immun. 40:653-658.
8. Clements, J. D., N. M. Hartzog, and F. L. Lyon. 1988. Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens. Vaccine 6:269-277.
9. Clements, J. D., F. L. Lyon, K. L. Lowe, A. L. Farrand, and S. El-Morshidy. 1986. Oral immunization with attenuated Salmonella enteritidis containing a recombinant plasmid which codes for production of the B subunit of heatlabile Escherichia coli enterotoxin. Infect Immun. 53:685-692.
10. Ellman, G. L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82:70-77.
11. Frangakis, M. V., W. J. Koopman, H. Kiyono, S. M. Michalek, and J. R. McGhee. 1982. An enzymatic method for preparation of dissociated murine Peyer's patch cells enriched for macrophages. J Immunol. Methods 48: 33-44.
12. Geysen, H. M., S. J. Rodda, T. J. Mason, G. Tribbick, and P. G. Schoofs. 1987. Strategies for epitope analysis using peptide synthesis J Immunol. Methods 102:259-274.
13. Holmgren, J., C. Czerkinsky, N. Lycke, and A.-M. Svennerholm. 1992. Mucosal immunity implications for vaccine development. Immunobiology 184: 157-179.
14. Jackson, R. J., K. Fujjhashi, J. Xu-Amano, H. Kiyono, C. O. Elson, and J. R. McGhee. 1993. Optimizing oral vaccines. induction of systemic and mucosal B-cell antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant Infect. Immun. 61:4272-4279.
15. Jacobs, E., R. Röck, and L. Dalehite. 1990. A B cell-, T cell-linked epitope located on the adhesin of Mycoplasma pneumoniae. Infect. Immun 58:2464-2469.
16. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
17. Lehner, T., R. Brookes, C. Panagiotidi, L. Tao, L. S. Klavinskis, J. Walker, P. Walker, R. Ward, L. Hussain, A. J. H. Gearing, S. E. Adams, and L. A. Bergmeir. 1993. T- and B-cell functions and epitope expression in nonhuman primates immunized with simian immunodeficiency virus antigen by the rectal route Proc. Natl. Acad. Sci. USA 90:8638-8642
18. McGhee, J. R., and H. Kiyono. 1993. New perspectives in vaccine development: immunity to infections. Infect. Agents Dis. 2:55-73.
19. McGhee, J. R., J. Mestecky, M. T. Dertzbaugh, J. H. Eldridge, M. Hirasawa, and H. Kiyono. 1992 The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 10:75-88
20. Merrifield, R. B. 1963. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 85:2149-2158.
21. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
22. Niman, H. L., A. M. H. Thompson, A. Yu, M. Markman, J. J. Willems, K. R. Herwig, N. A. Habib, C. B. Wood, R. A. Houghten, and R. A. Lerner. 1985. Anti-peptide antibodies detect oncogene-related proteins in urine. Proc. Natl. Acad. Sci. USA 82:7924-7928.
23. Pfeiffer, C., J. Murray, J. Madri, and K. Bottomly. 1991. Selective activation of Th1- and Th2-like cells in vivo: responses to human collagen IV. Immunol. Rev. 123:65-84.
24. Rollwagen, F. M., N. D. Pacheco, J. D. Clements, O. Pavlovskis, D. M. Rollins, and R. I. Walker. 1993. Killed Campylobacter elicits immune response and protection when administered with an oral adjuvant. Vaccine 11: 1316-1320.
25. Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12:227-257.
26. Sixma, T. K., S. E. Pronk, K. H. Kalk, B. A. M. van Zanten, A. M. Berghuis, and W. G. J. Hol. 1992. Lactose binding to heat-labile enterotoxin revealed by X ray crystallography. Nature (London) 355:561-564.
27. Sixma, T. K., S. E. Pronk, K. H. Kalk, E. S. Wartna, van B. A. M. Zanten, A. M. Berghuuis, and W. G. J. Hol. 1991. Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli. Nature (London) 351: 371-377.
28. Spangler, B. D. 1992. Structure and function of cholera toxin and related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 56:622-647.
29. Staats, H. F., R. J. Jackson, M. Mariarosaria, I. Takahashi, H. Kiyoao, and J. R. McGhee. 1994 Mucosal immunity to infection with implications for vaccine development. Curr Opin Immunol 6:572-583.
30. Stoll, B. J., A.-M. Svennerholm, L. Gothefors, D. Barua, S. Huda, and J. Holmgren. 1986. Local and systemic antibody responses to naturally acquired enterotoxigenic Escherichia coli diarrhoea in an endemic area J. Infect Dis. 153:527-534
31. Street, N. E., and T. R. Mosmann. 1991. Functional diversity of T lymphocytes due to secretion of different cytokines pattern. FASEB J. 5:171 177.
32. Sun, J.-B., J. Holmgren, and C. Czerkinsky. 1994. Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc. Natl. Acad. Sci. USA 91:10795-10799
33. Svennerholm, A.-M., C. Ahren, C. Wenneras, and J. Holmgren. 1991 Development of an oral vaccine against enterotoxigenic Escherichia coli diarrhoea, p. 287-294. In T. Wadstrom, H. Makela, A.-M. Svennerholm, and H. Woli-Watz (ed.), Molecular pathogenesis of gastrointestinal infections. Plenum, New York.
34. 33a. Takahashi, I., et al. Unpublished data.
35. Takahashi, I., I. Nakagawa, H. Kiyono, J. R. McGhee, J. D. Clements, and S. Hamada. 1995. Mucosal T cells induce systemic anergy for oral tolerance. Biophys. Biochem. Res. Commun. 206:414-420.
36. Takahashi, I., K. Matsushita, T. Nisizawa, N. Okahastri, M. W. Russell, Y. Suzuki, E. Manekata, and T. Koga. 1992. Genetic control of immune responses in mice to synthetic peptides of a Streptococcus mutans surface protein antigen. Infect Immun. 60:623-629.
37. Walker, R. I., and J. D. Clements. 1993. Use of heat-labile toxin of enterotoxigenic Escherichia coli to facilitate mucosal immunization Vaccine Rev 2: 1-10.
38. Wilson, A. D., M. Bailey, N. A. Williams, and C. R. Stokes. 1991. The in vitro induction of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant. Eur. J Immunol. 21:2333-2339
39. Xu-Amano, J., H. Kiyono, R. J. Jackson, H. Staats, K. Fujihashi, P. D. Burrows, C. O. Elson, S. Pillai, and J. R. McGhee. 1993. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J. Exp. Med. 178:1309-1320.
40. Yamamoto, T., and H. Yokota. 1983. Sequence of heat-labile enterotoxin of Escherichia coli pathogenic for humans. J Bacteriol. 155:728-733.