Molecular Diagnosis and Clinical Relevance of t(9;22), t(4;ll) and t(l;19) Chromosome Abnormalities in a Consecutive Group of 141 Adult Patients with Acute Lymphoblastic Leukemia

Leukemia and Lymphoma

Volumn 21, Issue 42130, 1996, Pages 457-466

  Rambaldi, Alessandro ^a,b   Attuati, Viviana ^a,b   Bassan, Renato ^a   Neonato, Maria Grazia ^a,b   Viero, Piera ^a   Battista, Raffaele ^c   Bona, Eros di ^c   Rossi, Giuseppe ^d   Pogliani, Enrico ^d   Ruggeri, Monica ^d   Amaru, Ricardo ^a   Rivolta, Anna ^e   Giudici, Giovanni ^e   Biondi, Andrea ^e   Barbui, Tiziano ^a  

^a OSPEDALI RIUNITI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c SAN BORTOLO HOSPITAL   (Italy)

^d Spedali civili Brescia Istituto di Clinica Medica   (Italy)

^e Clinica Pediatrica   (Italy)

Author keywords

ALL; chromosome translocations; molecular diagnosis

Indexed keywords

BCR ABL PROTEIN; CD19 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; HLA DR ANTIGEN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGE; AGED; ARTICLE; BLAST CELL; CANCER REGRESSION; CHROMOSOME 11Q; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION 1; CHROMOSOME TRANSLOCATION 4; CHROMOSOME TRANSLOCATION 9; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 19; CHROMOSOMES, HUMAN, PAIR 4; DISEASE-FREE SURVIVAL; FEMALE; FUSION PROTEINS, BCR-ABL; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, B-CELL, ACUTE; LEUKEMIA, CALLA-POSITIVE; LEUKEMIA, LYMPHOCYTIC, ACUTE, L2; LEUKEMIA, PRE-B-CELL; LEUKEMIA, T-CELL, ACUTE; MALE; MIDDLE AGED; PHILADELPHIA CHROMOSOME; POLYMERASE CHAIN REACTION; PROGNOSIS; PROSPECTIVE STUDIES; REMISSION INDUCTION; SURVIVAL ANALYSIS; TRANSLOCATION, GENETIC; TREATMENT OUTCOME;

EID: 0029927428     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428199609093444     Document Type: Article

References (33)

1. Bloomfield C D, Goldman A I, Alimena G, Berger R, Borgstrom G H, Brandt L, Catovsky D, de la Chapelle A, Dewalt G W, Garson O M, Garwicz S, Golomb H M, Hossfeld D K, Lawler S D, Mitelman F, Nilsson P, Pierre R V, Philip P, Prigogina E, Rowley G D, Sakurai M, Sandberg A A, Secker Walker L M, Tricot G, Van Den Berghe H, Van Orshoven A, Vuopio P, Whang-Peng J. Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia. Blood 1986; 67: 415 – 420
2. Gaynor J, Chapman D, Little C, McKenzie S, Miller W, Andreeff M, Arlin Z, Berman E, Kempin S, Gee T, Clarkson B. A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia: the Memorial Hospital experience since 1969. Journal of Clinical Oncology 1988; 6: 1014 – 1030
3. Walters R, Kantarjian H M, Keating M J, Estey E H, Trujillo J, Cork A, McCredie K B, Freireich E J. The importance of cytogenetic studies in adult acute lymphocytic leukemia. The American Journal of Medicine 1990; 89: 579 – 587
4. Bassan R, Battista R, Montaldi A, Rambaldi A, D'Emilio A, Viero P, Borleri G M, Buelli M, Dini E, Barbui T. Reinforced HEAV'D therapy for adult acute lymphoblastic leukemia: improved results and revised prognostic criteria. Hematological Oncology 1993; 11: 169 – 177
5. Raimondi S C. Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood 1993; 81: 2237 – 2251
6. Seeker Walker L M, Craig J M. Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review. Leukemia 1993; 7: 147 – 151
7. Maurer J, Janssen J W. G, Thiel E, Van Denderen J, Ludwig W D, Aydemir U, Heinze B, Fonatsch C, Harbott J, Reiter A, Riehm H, Hoelzer D, Bartram C. Detection of chimeric BCR-ABL genes in acute lymphoblastic leukemia by the polymerase chain reaction. The Lancet 1991; 337: 1055 – 1058
8. Saglio G, Guerrasio A, Rosso C, Lo Coco F, Frontani M, Annino L, Mandelli F. Detection of Ph1-positive acute lymphoblastic leukemia by PCR. The Lancet 1991; 338: 958
9. Westbrook C A, Hooberman A L, Spino C, Dodge R K, Larson R A, Davey F, Wurster-Hill D H, Sobol R E, Schiffer C, Bloomfield C. Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a cancer and leukemia group B study (8762). Blood 1992; 80: 2983 – 2990
10. Tuszynski A, Dhut S, Young B D, Lister T A, Rohatiner A Z, Amess J A. L, Chaplin T, Dorey E, Gibbons B. Detection and significance of bcr-abl mRNA transcripts and fusion proteins in Philadelphia-positive adult acute lymphoblastic leukemia. Leukemia 1993; 7: 1504 – 1508
11. Chen C S, Sorensen P H. B, Domer P H, Reaman G H, Korsmeyer S J, Heerema N A, Hammond G D, Kersey J H. Molecular rearrangement on chromosome llq23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood 1993; 81: 2386 – 2393
12. Crist W M, Carroll A J, Shuster J J, Behm F G, Whitehead M, Vietti T J, Look A T, Mahoney D, Ragab A, Pullen D J, Land V J. Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a pediatric oncology group study. Blood 1990; 76: 117 – 122
13. Secker Walker L M, Berger R, Fenaux P, Lai J L, Nelken B, Garson M, Michael P M, Hagemeijer A, Harrison C J, Kaneko Y, Rubin C M. Prognostic sificance of the balanced t(1;19) and unbalanced der(19)t(1;19) translocations in acute lymphoblastic leukemia. Leukemia 1992; 6: 363 – 369
14. Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce C M, Canaani E. The t (4; 11) chromosome translocations of human acute leukemias involves fusion between the ALL-1 gene encoding a protein with omology to Drosophila tri-torax gene and a gene AF4 on chromosome 4. Cell 1992; 71: 701 – 708
15. Tkachuk D C, Kohler S, Cleary M L. Involvement of a homolog of Drosophila tritorax by 11q23 chromosomal translocations in acute leukemias. Cell 1992; 71: 691 – 700
16. Nourse J, Mellentin J D, Galili N, Stanbridge E, Smith S E, Cleary M L. Chromosomal translocation t(1; 19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 1990; 60: 535 – 545
17. Kamps M P, Murre C, Sun X.-H, Baltimore D. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 1990; 60: 547 – 555
18. Biondi A, Rambaldi A, Rossi V, Elia L, Caslini C, Basso G, Battista R, Barbui T, Mandelli F, Masera G, Croce C M, Canaani E, Cimino G. Detection of ALL-1/AF4 fusion transcript by reverse transcription polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4; 11) translocation. Blood 1993; 82: 2943 – 2947
19. Dowing J R, Head D R, Raimondi S C, Carroll A J, Curcio-Brint A, Motroni T A, Hulshof M G, Domer P H. The der(11) encoded MLL/AF-4 fusion transcript is consistently detected in t(4; 11)(q21;q23) containing acute lymphoblastic leukemia. Blood 1994; 2: 330 – 335
20. Hilden J M, Chen C S, Moore R, Frestedt J, Kersey J H. Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the Polymerase chain reaction in t(4;11) acute leukemia. Cancer Res 1993; 53: 3853 – 3856
21. Hunger S P, Galili N, Carroll A J, Crist W, Link M P, Cleary M L. The t(1; 19) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood 1991; 77: 687 – 693
22. Privitera E, Kamps M P, Hayashi Y, Inaba T, Shapiro L H, Raimondi S C, Behm F, Hendershot L, Carroll A J, Baltimore D, Look A T. Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia. Blood 1992; 79: 1781 – 1788
23. Bassan R, Battista R, Rohatiner A Z. S, Love S, Carter M, Buelli M, Viero P, D'Emilio A, MacCallum P, Ames J, Dini E, Barbui T, Lister T A. Treatment of adult acute lymphoblastic leukemia (ALL) over a 16 year period. Leukemia 1992; 6 (Suppl. 2) 186 – 190
24. Bassan R, Battista R, Viero P, Pogliani E, Rossi G, Lambertenghi-Delilicrs G, Rambaldi A, D'Emilio A, Buelli M, Borleri G, Corneo G, Dini E, Barbui T. Intensive therapy for adult acute lymphoblastic leukemia: preliminary results of the Idarubicir/Vincristine/L-Asparaginase/Prednisolone regiment. Seminars in Oncology 1993; 20 (Suppl. 8) 39 – 46
25. Rohatiner A Z. S, Lister T A. The challenge of acute lymphoblastic leukaemia in adults. Br. J. Haematol 1993; 85: 641 – 645
26. Kantarjian H, Talpaz M, Estey E, Ku S, Kurzrock R. What is the contribution of molecular studies of BCR-ABL positive disease in adult acute leukemia?. Am. J. Med 1994; 96: 133 – 138
27. Annino L, Ferrari A, Cedrone M, Giona F, LoCoco F, Meloni G, Arcese W, Mandelli F. Adult Philadelphia-chromosome-positive acute lymphoblastic leukemia: experience of treatments during a ten year period. Leukemia 1994; 8: 664 – 667
28. Radich J P, Kopecky K J, Boldt D H, Head D, Slovack M L, Babu R, Kirk J, Lee A, Kessler P, Appelbaum F, Gehly G. Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction. Leukemia 1994; 8: 1688 – 1695
29. Griesinger F, Elfers H, Ludwig W D, Falk M, Rieder H, Harbott J, Lampert F, Heinze B, Hoelzer D, Thiel E, Riehm H, Wormann B, Fonatsch C, Hiddemann W. Detection of HRX-FEL fusion transcripts in pre-pre-B-ALL with and without cytogenetic demonstration of t(4;11). Leukemia 1994; 8: 542 – 548
30. Izraeli S, Janssen J W. G, Haas O A, Harbott J, Brok-Simoni F, Walther J U, Kovar H, Henn T, Ludwig W D, Reiter A, Rechavi G, Bartram C R, Gadner H, Lion T. Detection and clinical relevance of genetic abnormalities in pediatric acute lymphoblastic leukemia: a comparison between cytogenetic and polymerase chain reaction analyses. Leukemia 1993; 7: 671 – 678
31. Charrin C. Karyotypes of 433 adults with acute lymphoblastic leukemia (ALL): a prospective collaborative study. Blood 1993; 82 (Suppl. 1 abstr) 217
32. Rivera G K, Pinkel D, Simone J V, Hancock M L, Crist W M. Treatment of acute lymphoblastic leukemia: 30 years' experience at St Jude Children's Research Hospital. The New England Journal of Medicine 1993; 329: 1289 – 1295
33. Proctor S J. Acute lymphoblastic leukemia in adults: the case for a strategic shift in study approach. British Journal of Haematology 1994; 88: 229 – 233