Healing of tympanic membrane after myringotomy during Streptococcus pneumoniae otitis media: An otomicroscopic and histologic study in the rat

Annals of Otology, Rhinology and Laryngology

Volumn 105, Issue 5, 1996, Pages 397-404

  Magnuson, Karin ^a   Hermansson, Ann ^b   Hellström, Sten ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

myringotomy; rat; Streptococcus pneumoniae; tympanic membrane

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONICITY; CONNECTIVE TISSUE; CONTROLLED STUDY; DISEASE COURSE; HEALING; HISTOPATHOLOGY; MALE; MICROSCOPY; MYRINGOTOMY; NONHUMAN; OTITIS MEDIA; PRIORITY JOURNAL; RAT; STREPTOCOCCUS PNEUMONIAE;

EID: 0029927320     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348949610500513     Document Type: Article

References (30)

1. Ingvarsson L, Lundgren K, Olofsson B, Wall S. Epidemiology of acute otitis media in children. A prospective study of acute otitis media in children. Incidence in an urban population. Acta Otolaryngol [Suppl] (Stockh) 1982(suppl 388):29-52.
2. Pukander J, Karma P, Sipilä M. Occurrence and recurrence of acute otitis media among children. Acta Otolaryngol (Stockh) 1982;94:479-86.
3. Prellner K, Kahn O, Harsten G. Middle ear problems in childhood. Acta Otolaryngol [Suppl] (Stockh) 1992(suppl 493): 93-8.
4. Kamme C, Lundgren K, Mårdh P-A. The aetiology of acute otitis media in children. Scand J Infect Dis 1971;3:217-23.
5. Klein JO. Microbiology of otitis media. Ann Otol Rhinol Laryngol [Suppl] 1980;89(suppl 68):98-101.
6. Luotonen J, Herva B, Karma P, Timonen M, Leinonen M, Mäkelä PH. The bacteriology of acute otitis media in children with special reference to Streptococcus pneumoniae as studied by bacteriological and antigen detection methods. Scand J Infect Dis 1981;13:177-83.
7. Lundgren K. Antibiotic treatment of acute otitis media in children. In: Treatment of Ear Nose and Throat Infections; workshop. National Board of Health and Welfare and Drug Information Committee, Sweden, 1985:37-45.
8. Puhakka H, Virolainen E, Aantaa E, Tuohimaa P, Eskola J, Ruuskanen O. Myringotomy in the treatment of acute otitis media in children. Acta Otolaryngol (Stockh) 1979;88:122-6.
9. Qvarnberg Y. Acute otitis media. A prospective clinical study of myringotomy and antimicrobial treatment. Acta Otolaryngol [Suppl] (Stockh) 1981(suppl 375).
10. Karma P. Finnish approach to the treatment of acute otitis media. Report of the Finnish Consensus Conference. Ann Otol Rhinol Laryngol [Suppl] 1987;96(suppl 129).
11. Hermansson A, Prellner K, Hellström S. Persistent structural changes in the middle ear mucosa of the rat, after an experimentally induced episode of pneumococcal otitis media. Acta Otolaryngol (Stockh) 1990;109:421-30.
12. Söderberg O, Hellström S, Stenfors L-E. Structural changes in the tympanic membrane after repeated tympanostomy tube insertion. Acta Otolaryngol (Stockh) 1986;102:382-90.
13. Stenfors L-E, Carlsöö B, Salén B, Winblad B. Repair of experimental tympanic membrane perforations. Acta Otolaryngol (Stockh) 1980;90:332-41.
14. Johnson AP, Smallman LA, Kent SE. The mechanism of healing of tympanic membrane perforations. A two-dimensional hislological study in guinea pigs. Acta Otolaryngol (Stockh) 1990;109:406-15.
15. Hellström S, Salén B, Stenfors L-E. Anatomy of the rat middle ear. A study under the dissection microscope. Acta Anat 1982;112:346-52.
16. Albiin N, Hellström S, Stenfors L-B, Cerne A. Middle ear mucosa in rats and humans. Ann Otol Rhinol Laryngol [Suppl] 1986;95(suppl 126).
17. Alm PE, Bloom GD, Hellström S, Stenfors L-E, Widemar L. Mast cells in the pars flaccida of the tympanic membrane. A quantitative morphological and biochemical study in the rat. Experientia 1983;39:287-9.
18. Magnuson K, Hellström S. Early structural changes in the rat tympanic membrane during pneumococcal otitis media. Eur Arch Otorhinolaryngol 1994;251:393-8.
19. Hermansson A, Hellström S, Prellner K. Mucosa lchanges induced by experimental pneumococcal otitis media are prevented by penicillin V. Otolaryngol Head Neck Surg 1991;105: 578-85.
20. Kaleida PH, Casselbrant ML, Rockette HE, et al. Amoxicillin or myringotomy or both for acute otitis media: results of a randomized clinical trial. Pediatrics 1991;87:466-74.
21. Lidén M, Flodström A, Thore M. Treatment of early recurrences of acute purulent otitis media; value of myringotomy. Acta Otolaryngol (Stockh) 1988;106:441-7.
22. Van Buchem FL, Dunk JHM, van't Hof MA. Therapy of acute otitis media: myringotomy, antibiotics, or neither? A double-blind study in children. Lancet 1981;2:883-7.
23. Baquero F, Loza E. Antibiotic resistance of microorganisms involved in ear, nose and throat infections. Pediatr Infect Dis J 1994;13:S9-S14.
24. Appelbaum PC. Antimicrobial resistance in Streptococcus pneumoniae: an overview. Clin Infect Dis 1992;15:77-83.
25. Klugman KP. Pneumococcal resistance to antibiotics. Clin Microbiol Rev 1990;3:171-96.
26. Schmidt S-H, Hellström S. Tympanic-membrane structure - new views. A comparative study. ORL J Otorhinolaryngol Relat Spec 1991;53:32-6.
27. Hermansson A, Emgård P, Prellner K, Hellström S. A rat model for pneumococcal otitis media. Am J Otolaryngol 1988; 9:97-101.
28. Alwmark A, Bengmark S, Gullstrand P, Schalén C. Improvement of the splenectomized rat model for overwhelming pneumococcal infection. Standardization of the bacterial inocula. Eur Surg Res 1981;13:339-43.
29. Von Unge M, Decraemer WF, Bagger-Sjöbäck D. Tympanic membrane changes in experimental purulent otitis media. In: von Unge M. Mechanical properties of the tympanic membrane. An experimental study [Dissertation]. Stockholm, Sweden: Karolinska Institute, 1994.
30. Sadé J. Atelectatic tympanic membrane: histologic study. Ann Otol Rhinol Laryngol 1993;102:712-6.