A glucocorticoid antagonist, mifepristone affects anti-Candida activity of murine neutrophils in the presence of prednisolone in vitro and experimental candidiasis of prednisolone-treated mice in vivo

FEMS Immunology and Medical Microbiology

Volumn 13, Issue 4, 1996, Pages 311-316

  Abe, Shigeru ^a   Ohnishi, Megumi ^a   Nohmi, Takao ^a   Katoh, Masahiro ^a   Tansho, Shigeru ^a   Yamaguchi, Hideyo ^a  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Candida albicans; Glucocorticoid; Mifepristone; Murine candidiasis; Neutrophil; Prednisolone

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; MIFEPRISTONE; PREDNISOLONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

EID: 0029927259     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-8244(96)00007-7     Document Type: Article

References (20)

1. Bodey, G.P. (1993) Candidiasis; Pathogenesis, Diagnosis and Treatment, 2nd. Ed. Raven Press, New York.
2. Matsumoto, M., Matsubara, S. and Matsumoto, T. (1987) Protective effect of human granulocyte colony stimulating factor on microbial infection in neutropenic mice. Infect. Immun. 55, 2715-2720.
3. Uchida, K., Yamamoto, Y., Klein, T.W., Friedman, H. and Yamaguchi, H. (1992) Granulocyte-colony stimulating factor facilitates the restoration of resistance to opportunistic fungi in neutropenic mice. J. Med. Vet. Mycol. 30, 293-300.
4. Nohmi, T., Abe, S., Tansho, S. and Yamaguchi, H. (1994) Suppression of anti-Candida activity of murine neutrophils by glucocorticoids. Microbiol. Immunol. 38, 977-982.
5. Perret, T.G. and Lemaire, G. (1986) Dexamethasone inhibits antitumor potential of activated macrophages by a receptor mediated action. Biochem. Biophys. Res. Commun. 136, 130-136.
6. Akagawa, G., Abe, S. and Yamaguchi, H. (1995) Mortality of Candida albicans-infected mice is facilitated by superinfection of Esherichia coli and administration of its lipopolysaccharide. J. Infect. Dis. 171, 1539-1544.
7. Tansho, S., Abe, S. and Yamaguchi, H. (1994) Inhibition of Candida albicans growth by murine peritoneal neutrophils and augmentation of the inhibitory activity by bacterial lipopolysaccharide and cytokines. Microbiol. Immunol. 38, 379-383.
8. Abe, S., Satoh, T., Tokuda, Y., Tansho, S. and Yamaguchi, H. (1994) A rapid colorimetric assay for determination of leukocyte-mediated inhibition of mycelial growth of Candida albicans. Microbiol. Immunol. 38, 385-388.
9. Aoyagi, K., Itoh, N., Abe, F., Abe, S., Uchida, K., Ishizuka, M., Takeuchi, T. and Yamaguchi, H. (1992) Enhancement by ubenimex (Bestatin) of host resistance to Candida albicans infection. J. Antibiotics 45, 1778-1784.
10. Uchida, K., Yamaguchi, H. and Shibuya, K. (1991) The therapeutic effects of itraconazole, a new triazole antifungal agent, for experimental fungal infections. Jpn. J. Antibiotics 44, 588-599 (in Japanese).
11. Aoyagi, K., Abe, F., Nemoto, K., Abe, S., Ishizuka, M., Takeuchi, T. and Yamaguchi, H. (1994) The novel immunostimulant N-563, an analogue of deoxyspergualin, promotes resistance to Candida albicans infection in mice. J. Antibiotics 47, 1077-1083.
12. SAS Institute Inc. (1990) The GLM procedure, pp. 891-996 and pp. 1195-1210. In SAS/STAT User's Guide, version 6, 4th Ed, SAS Institute Inc., Cary, NC, USA.
13. Nozawa, R.T., Yanaki, N. and Yokota, T. (1980) Cell growth and antimicrobial activity of mouse peritoneal macrophages in response to glucocorticoids, choleragen and lipopolysaccharide. Microbiol. Immunol. 24, 1199-1209.
14. Schaffiner, A. and Schaffiner, T. (1987) Glucocorticoid-induced impairment of macrophage antimicrobial activity: mechanisms and dependence on the state of activation. Rev. Infect. Dis. 9, 620-629.
15. Heikinheimo, O., Tevilin, M., Shoupe, D., Croxatto, H. and Lahfeenmaki, P. (1986) Quantitation of RU486 in human plasma by HPLC and RIA after column chromatography. Contraception 34, 613-624.
16. Bistoni, F., Baccarini, M., Blasi, E., Marconi, P., Puccetti, P. and Garaci, E. (1983) Correlation between in vivo and in vitro studies of modulation of resistance to experimental Candida albicans infection by cyclophosphamide in mice. Infect. Immun. 40, 46-55.
17. Kullberg, B.-J., van't Wout J.W., Hoogstraten, C. and van Furth, R. (1993) Recombinant interferon-γ enhances resistance to acute disseminated Candida albicans infection in mice. J. Infect. Dis. 168, 436-443.
18. Roilides, E., Uhlig, K., Venzon, D., Pizzo, P.A. and Walsh, T.J. (1993) Prevention of corticosteroid-induced suppression of human polymorphonuclear leukocyte-induced damage of Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon. Infect. Immun. 61, 4870-4877.
19. Waage, A., Slupphaug, G. and Shalaby, R. (1990) Glucocorticoids inhibit the production of IL6 from monocytes, endothelial cells and fibroblasts. Eur. J. Immunol. 20, 2439-2443.
20. Nohmi, T., Abe, S., Dobashi, K., Tansho, S. and Yamaguchi, H. (1995) Suppression of anti-Candida activity of murine neutrophils by progesterone in vitro: A possible predisposing factor for vaginal Candidiasis in pregnant women. Microbiol. Immunol. 39, 405-409.