The immune response against p53 in patients with squamous cell carcinoma of the upper aerodigestive tract is unrelated to mutations in hot spot regions;DIE IMMUNANTWORT GEGEN P53 BEI PATIENTEN MIT PLATTENEPITHELKARZINOMEN DER OBEREN LUFT- UND SPEISEWEGE IST UNABHANGIG VON DER P53-PUNKTMUTATION

Laryngo- Rhino- Otologie

Volumn 75, Issue 5, 1996, Pages 301-305

  Gottschlich, S ^a,b   Maass, J D ^a   Gorogh T ^a   Lippert, B M ^a   Werner, J A ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Exon; p53; p53 Antibody; Point mutation; Squamous cell carcinoma; Upper aerodigestive tract

Indexed keywords

ANTIBODY;

ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEAD AND NECK CARCINOMA; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; POINT MUTATION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SQUAMOUS CELL CARCINOMA;

EID: 0029927197     PISSN: 09358943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-997583     Document Type: Article

References (34)

1. Angelopoulou, K., E. P. Diamandis, D. J. A. Sutherland. J. A. Kellen, P. S. Bunting: Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers. Int. J. Cancer 58 (1994) 480-487
2. Bartek, J., R. Iggo, J. Cannon, D. P. Lane: Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene 5 (1990) 1595-1602
3. Caron de Fromentel, C., F. May-Levin, H. Moriesse, J. Lemerle, K. Chandrasekaran, P. May: Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma. Int. J. Cancer 39 (1987) 185-189
4. Crawford, L. V., D. C. Pim, R. D. Bulbrook: Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer. Int. J. Cancer 30 (1982) 403-408
5. Crawford. L. V., D. C. Pim, P. Lamb: The cellular protein p53 in human tumors. Mol. Biol. Med. 2 (1984) 261-272
6. D'Amico, D., D. Carbone, T. Mitsudomi, M. Nau, J. Fedorko, E. Russel, B. Johnson, D. Buchhagen, S. Bodner, R. Phelps, A. Gazdar, J. D. Minna: High frequency of somatically acquired p53 mutations in non-small cell lung cancer cell lines and tumors. Oncogene 7 (1992) 339-346
7. Davidoff, A. M., J. D. Iglehart, J. R. Marks: Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancer. Proc. Natl. Acad. Sci. USA 89 (1992) 3439-3442
8. Fenaux, P., P. Jonevaux, I. Quiquandon, J. L. Lai, M. Vanrumbeke. M. H, Loucheaux-Lefebvre, F. Bauters, R. Berger, J. P. Kerckaert: Blood (78) 1652-1658
9. Finley, C. A., P. W. Hinds, A. J. Levine: The p53 proto-oncogene can act as a suppressor of transformation. Cell 57 (1989) 1083-1093
10. Gannon, J. V., R. Greaves, R. Iggo, D. P. Lane: Activating mutations in p53 produce a common conformational effect - a monoclonal antibody specific for the mutant form. EMBO J. 9 (1990) 1595-1602
11. Green, J. A., B. Mudenda, J. Jenkins, S. J. Leinster, M. Tarunina, B. Green, L. Robertsen: Serum p53 auto-antibodies: Incidence in familial breast cancer. Eur. J. Cancer 30 A (1994) 580-584
12. Hall, P. A., A. Ray, N. R. Lemoine, C. A. Midgley, T. Krausz, D. P. Lane: p53 immunostaining as a marker of malignant disease in diagnostic cytopathology. Lancet 338 (1991) 513
13. Hollstein, M., D. Sadransky, B. Vogelstein, C. C. Harris: p53 mutations in human cancer. Science 253 (1991) 49-53
14. Houbiers, J. G. A., S. H. van der Burg, L. M. G. van de Watering, R. A. E. M. Tollenaar, A. Brand, C. J. H. van de Velde, C. J. M. Melief: Antibodies against p53 are associated with poor prognosis of colorectal cancer. Br.J. Cancer 72 (1995) 637-641
15. Jonveaux, P., P. Fenaux, J. M. Pignon, J. L. Lai, I. Quiquandon, J. P. Kerkaert, M. H. Goossens, F. Bauters, R. Berger: Mutations of the p53 gene in myelodysplastic syndromes. Oncogene 6 (1991) 2243-2247
16. Kern, S. E., J. A. Pietenpol, S. Thiagalingam, A. Seymour, K. W, Kinzler, B. Vogelstein: Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256 (1992) 827-830
17. Labrecque, S., N. Naor, D. Thomson, G. Matlashewski: Analysis of the anti-p53 response in cancer patients. Cancer Res. 53 (1993) 3468-3471
18. Levine, A. J., J. Momand, C. A. Finley: The p53 tumor suppressor gene. Nature 351 (1991) 453-456
19. Lubin, R., B. Schlichtholz, D. Bengoufa, G. Zalcman, J. Tredaniel, A. Hirsch, C. Caron de Fromentel, C. Preudhomme, P. Fenaux, G. Fournier, P. Mangin, P. Laurent-Puig, G. Pelletier, M. Schlumberger, F. Desgrandchamps, A. Le Duc, J. P. Peyrat, N. Janin, B. Bressac, T. Soussi: Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: Distribution on primary epitopes and exposure on protein surface. Cancer Res. 53 (1993) 5872-5876
20. Luo, J.-C., R. Zehab, S. Anttila, M. Ridanpaa, K. Husgafvael-Pursiainen, W. Carney, I. DeVivo, C. Milling, P. W. Brandt-Rauf: Detection of serum p53 protein in lung cancer patients. J. O. M. 36 (1994) 155-160
21. Maass, J. D., T. Görögh, J. I. Paulsen, B. M. Lippert, I. O. Rathke, J. A. Werner: More accurate p53 detection possible with advanced tissue homogenisation. Cancer Res. Clin. Oncol. Suppl. 2 (1995) A27
22. Maass, J. D., S. Gottschlich, B. M. Lippert, A. M. Niemann, T. Görögh, J. A. Werner: Antikörperbildung gegen das zelluläre Protein p53 bei Patienten mit Plattenepithelkarzinomen der oberen Luft- und Speisewege. Laryngo-Rhino-Otol. 75 (1996) 3-56
23. Mullis, K. B., F. A. Faloona: Specific synthesis of DNA in vitro via a polymerase-analyzed chain reaction. Methods Enzymol. 155 (1987) 335-350
24. Peyrat, J. P., J. Bonneterre, R. Lubin, L. Vanlemmens, J. Fournier, T. Soussi: Prognostic significance of circulating p53 antibodies in patients undergoing surgery for locoregional breast cancer. Lancet 345 (1995) 621-622
25. Preudhomme, C., R. Lubin, P. Lepelley, M. Vanrumbeke, P. Fenaux: Detection of serum p53 antibodies and their correlation with p53 mutations in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 8 (1994) 1589-1591
26. Rotter, V., O. N. Witte, R. Coffman, D. Baltimore: Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50.J. Viral. 36 (1980) 547-555 .
27. Schlichtholz, B., Y. Legros, D. Gillet, C. Gaillard, M. Marty, D. Lane, F. Calvo, T. Soussi: The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot. Cancer Res. 52 (1992) 6380-6384
28. Schlichtholz, B., J. Tredaniel, R. Lubin, G. Zalcman, A. Hirsch, T. Soussi: Analyses of p53 antibodies in sera of patients with lung carcinoma define immunodominant regions in the p53 protein. Br. J. Cancer 69 (1994) 809-816
29. Stephen, C. W., D. P. Lane: Mutant conformation of p53 - precise epitope mapping using a filamentous phage epitope library. J. Mol. Biol. 225 (1992) 577-583
30. Takahashi, T., M. M. Nau, I. Chiba, M. J. Birrer, R. K. Rosenberg, M. Vinocour, M. Levitt, H. Pass, A. F. Gazdar: p53: a frequent target for genetic abnormalities in lung cancer. Science 246 (1989) 491-494
31. Takahashi, T, T. Takahashi, H. Suzuki, T. Hida, Y. Sekido, Y. Ariyoshi, R. Ueda: The p53 gene is very frequently mutated in small cell lung cancer with a distinct nucleotide substitution pattern. Oncogene 6 (1991) 1775-1778
32. Teneriello, M. G., M. Ebina, R. I. Linnoila, M. Henry, J. D. Nash, R. C. Park, M. J. Birrer: p53 and Ki-ras gene mutations in epithelial ovarian neoplasms. Cancer Res. 53 (1993) 3103-3108
33. Vogelstein, B., K. W. Kinzler: p53 function and dysfunction. Cell 70 (1992) 523-526
34. Winter, S. F., J. D. Minna, B. E. Johnson, T. Takahashi, A. Gazdar, D. P. Carbone: Development of antibodies against p53 in lung cancer appears to be dependent on the type of p53 mutation. Cancer Res. 52 (1992) 4168-4174