Inhibition of lipolysis and muscle protein degradation by EPA in cancer cachexia

Nutrition

Volumn 12, Issue SUPPL.1, 1996, Pages

  Tisdale, Michael J ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Cachexia; EPA; Inhibition; Lipolysis; Proteolysis

Indexed keywords

ANIMALIA;

CARBOHYDRATE; DOCOSAHEXAENOIC ACID; FISH OIL; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; INTERLEUKIN 6; POLYUNSATURATED FATTY ACID; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CACHEXIA; CARBOHYDRATE INTAKE; CHO CELL; CONFERENCE PAPER; LIPID METABOLISM; LIPOLYSIS; MOUSE; NITROGEN METABOLISM; NONHODGKIN LYMPHOMA; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; STOMACH CANCER; WEIGHT REDUCTION;

ADENOCARCINOMA; ANIMALS; CACHEXIA; COLONIC NEOPLASMS; DINOPROSTONE; EICOSAPENTAENOIC ACID; FISH OILS; LIPOLYSIS; MICE; MUSCLE PROTEINS; NEOPLASM TRANSPLANTATION; TUMOR CELLS, CULTURED;

EID: 0029926812     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/0899-9007(95)00066-6     Document Type: Article

References (30)

1. DeWys WD. Weight loss and nutritional abnormalities in cancer patients: incidence, severity and significance. Clin Oncol 1986;5:251
2. DeWys WD. Management of cancer cachexia. Semin Oncol 1985;12:452
3. Theologides A. Pathogenesis of cachexia in cancer: a review and a hypothesis. Cancer 1972;29:484
4. Evans WK, Makuch R, Clamon GH, et al. Limited impact of total parenteral nutrition on nutritional status during treatment for small cell lung cancer. Cancer Res 1985;45:3347
5. Fearon KCH, Carter DC. Cancer cachexia. Ann Surg 1988;208:1
6. Hyltander A, Körner U, Lundholm KG. Evaluation of mechanisms behind elevated energy expenditure in cancer patients with solid tumours. Eur J Clin Invest 1993;23:46
7. Drott C, Svaninger G, Lundholm K. Increased urinary excretion of cortisol and catecholamines in malnourished cancer patients. Ann Surg 1988;196:645
8. Norton JA, Moley JF, Green MV, Carson RE, Morrison SD. Parabiotic transfer of cancer anorexia/cachexia in male rats. Cancer Res 1985;45:5547
9. Oliff A, Defo-Jones D, Boyer M, et al. Tumors secreting human TNF/cachectin induce cachexia in mice. Cell 1987;50:555
10. Strassman G, Fong M, Kenney JS, Jacob CO. Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J Clin Invest 1992;89:1681
11. Darling G, Fraker DL, Jensen JC, Gorschboth CM, Norton JA. Cachectic effects of recombinant human tumor necrosis factor in rats. Cancer Res 1990;50:4008
12. Socher SH, Martinez D, Craig JB, Kahn G, Oliff A. Tumor necrosis factor not detectable in patients with clinical cancer cachexia. J Natl Cancer Inst 1988:80:595
13. Balkwill F, Burke F, Talbot D, et al. Evidence for tumour necrosis factor/cachectin production in cancer. Lancet 1987;ii:1229
14. Shenouda G, Labateya M, Souhami L, Donath D, Vuong T, Joseph L. Elevated serum cytokines in patients with malignancy and weight loss. Int J Oncol 1993;2:115
15. Block K, Garrett IR, Mundy GR. Chinese hamster ovary cells transfected with the murine IL-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor bearing nude mice. Endocrinology 1991;128:2657
16. Fearon KCH, McMillan DC, Preston T, Winstanley P, Cruickshank AM, Shenkin A. Elevated circulating interleukin-6 is associated with an acute phase response, but reduced fixed hepatic protein synthesis in patients with cancer. Ann Surg 1991;213:26
17. Soda K, Kawaskami M, Kashii A, Miyata M. Characterization of mice bearing subclones of colon 26 adenocarcinoma disqualifies interleukin-6 as the sole inducer of cachexia. Jpn J Cancer Res 1994;85:1124
18. Costa G, Holland JF. Effects of Krebs-2 carcinoma on the lipid metabolism of male Swiss mice. Cancer Res 1966;22:1081
19. Kitada S, Hays EF, Mead JF. A lipid mobilizing factor in serum of tumor-bearing mice. Lipids 1980;15:168
20. Beck SA, Tisdale MJ. Production of lipolytic and proteolytic factors by a murine tumor producing cachexia in the host. Cancer Res 1987;47:5919
21. Beck SA, Mulligan HD, Tisdale MJ. Lipolytic factors associated with murine and human cancer cachexia. J Natl Cancer Inst 1990;82:1922
22. Beck SA, Tisdale MJ. Lipid mobilising factors specifically associated with cancer cachexia. Br J Cancer 1991;63:846
23. Beck SA, Groundwater P, Barton C, Tisdale MJ. Alterations in serum lipolytic activity of cancer patients with response to therapy. Br J Cancer 1990;62:822
24. Tisdale MJ, Dhesi JK. Inhibition of weight loss by ω-3 fatty acids in an experimental cachexia model. Cancer Res 1990;50:5022
25. Beck SA, Smith KL, Tisdale MJ. Anticachectic and antitumor effect of eicosapentaenoic acid and its effect on protein turnover. Cancer Res 1991;51:6089
26. Tisdale MJ, Beck SA. Inhibition of tumour-induced lipolysis in vitro and cachexia and tumour growth in vivo by eicosapentaenoic acid. Biochem Pharmacol 1991;41:103
27. Hudson EA, Beck SA, Tisdale MJ. Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal by linoleic acid. Biochem Pharmacol 1993;45:2189
28. Hussey HJ, Tisdale MJ. Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo. Br J Cancer 1994;70:6
29. Smith KL, Tisdale MJ. Mechanism of muscle protein degradation in cancer cachexia. Br J Cancer 1993;68:314
30. Butcher RN, Baird CE, Sutherland EW. Effects of lipolytic and antilipolytic substances on adenosine 3', 5'-monophosphate levels in isolated fat cells. J Biol Chem 1968;248:1705