Intrahepatic blood flow distribution in the perfused rat liver: Effect of hepatic artery perfusion

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 271, Issue 4 34-4, 1996, Pages

  Burczynski, Frank J ^a,b   Luxon, Bruce A ^a,c   Weisiger, Richard A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MANITOBA   (Canada)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

heterogeneity; isolated perfused rat liver; multiple indicator dilution

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW VELOCITY; HEPATIC ARTERY; ISOTOPE LABELING; LIVER BLOOD FLOW; LIVER ISCHEMIA; LIVER PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029926561     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.271.4.g561     Document Type: Article

References (32)

1. Bass, L., S. Keiding, K. Winkler, and N. Tygstrup. Enzymatic elimination of substrates flowing through the intact liver. J. Theor. Biol. 61: 393-409, 1976.
2. Bass, L., M. S. Roberts, and P. J. Robinson. On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination. J. Theor. Biol. 126: 457-482, 1987.
3. Bass, L., P. Robinson, and A. J. Bracken. Hepatic elimination of flowing substrates: the distributed model. J. Theor. Biol. 72: 161-184, 1978.
4. Bass, N. M., J. A. Manning, and R. A. Weisiger. Increased sinusoidal volume and solute extraction during retrograde liver perfusion. Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G1041-G1048, 1989.
5. Bassingthwaighte, J. B., R. B. King, and S. A. Roger. Fractal nature of regional myocardial blood flow heterogeneity. Circ. Res. 65: 578-590, 1989.
6. Berlin, N. I., R. A. Dudley, L. Garby, H. Heimpel, M. Lee, S. M. Lewis, P. McIntyre, P. L. Mollison, Y. Najean, and J. Pettit. Recommended method for radioisotope red-cell survival studies. Br. J. Haematol. 45: 659-666, 1980.
7. Brauer, R. W., G. F. Leong, R. F. McElroy, and R. J. Holloway. Circulatory pathways in the rat liver as revealed by P-32 chromic phosphate colloid uptake in the isolated perfused liver preparation. Am. J. Physiol. 184: 593-598, 1956.
8. Brissot, P., T. L. Wright, W. L. Ma, and R. A. Weisiger. Efficient clearance of non-transferrin-bound iron by rat liver: implications for hepatic iron loading in iron overload states. J. Clin. Invest. 76: 1463-1470, 1985.
9. Daniel, P. M., and M. M. L. Prichard. Effects of stimulation of the hepatic nerves and of adrenalin upon the circulation of the portal venous blood within the liver. J. Physiol. Lond. 114: 538-548, 1951.
10. Daniel, P. M., and M. M. L. Prichard. Variations in the circulation of the portal venous blood within the liver. J. Physiol. Lond. 114: 521-537, 1951.
11. Gores, G. J., L. J. Kost, and N. F. Larusso. The isolated perfused rat liver: conceptual and practical considerations. Hepatology 6: 511-517, 1986.
12. Goresky, C. A. A linear method for determining liver sinusoidal and extravascular volumes. Am. J. Physiol. 204: 626-640, 1963.
13. Goresky, C. A. The modeling of tracer exchange and sequestration in the liver. Federation Proc. 43: 154-160, 1984.
14. Greenway, C. V., and L. Bass. Derecruitment in cat liver: extension of undistributed parallel tube model to effects of low hepatic blood flow on ethanol uptake. Can. J. Physiol. Pharmacol. 1225: 1231, 1989.
15. Greenway, C. V., and W. W. Lautt. Hepatic circulation. In: Handbook of Physiology. The Gastrointestinal System. Motility and Circulation. Bethesda, MD: Am. Physiol. Soc., 1989, sect. 6, vol. I, pt. 2, chapt. 41, p. 1519-1564.
16. 131I-labelled human growth hormone of high specific radioactivity. Biochem. J. 89: 114-123, 1963.
17. Griffen, W. O., D. G. Levitt, C. J. Ellis, and N. Lifson. Intrahepatic distribution of hepatic blood flow: single-input studies. Am. J. Physiol. 218: 1474-1479, 1970.
18. Lautt, W. W., D. J. Legare, and M.A. D'Almeida. Adenosine as putative regulator of hepatic arterial flow (the buffer response). Am. J. Physiol. 248 (Heart Circ. Physiol. 17): H331-H338, 1993.
19. Lautt, W. W., J. Schafer, and D. J. Legare. Hepatic blood flow distribution: consideration of gravity, liver surface, and norepinephrine on regional heterogeneity. Can. J. Physiol. Pharmacol. 71: 128-135, 1993.
20. Lee, H. J., and W. L. Chiou. Marked heterogeneity in the intrahepatic distribution of quinidine in rats: Implications in pharmacokinetics. J. Pharmacol. Sci. 79: 778-781, 1990.
21. Lifson, N., D. G. Levitt, W. O. Griffen, and C. J. Ellis. Intrahepatic distribution of hepatic blood flow: double-input studies. Am. J. Physiol. 218: 1480-1488, 1970.
22. McCuskey, R. S. A dynamic and static study of hepatic arterioles and hepatic sphincters. Am. J. Anat. 119: 455-478, 1966.
23. McCuskey, R, S., F. D. Reilly, P. A. Mccuskey, and R. V. W. Dimlich. In vivo microscopy of the hepatic microvascular system. In: 10th European Conference on Microcirculation, edited by D. H. Lewis. Basel: Karger, 1979, p. 73-76.
24. Mendel, C. M., R. A. Weisiger, and R. R. Cavalieri. Uptake of 3,5,3′-triiodothyronine by the perfused rat liver: return to the free hormone hypothesis. Endocrinology 123: 1817-1824, 1988.
25. Ralston, M. L., and R. I. Jennrich. DUD, a derivative-free algorithm for nonlinear least squares. Technometrics 20: 7-14, 1978.
26. Reichen, J. Role of the hepatic artery in canalicular bile formation by the perfused rat liver. A multiple indicator dilution study. J. Clin. Invest. 81: 1462-1469, 1988.
27. Roberts, M. S., J. D. Donaldson, and M. Rowland. Models of hepatic elimination: comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination. J. Pharmacokinet. Biopharmacol. 16: 41-83, 1988.
28. Ternberg, J. L., and H. R. Butcher. Blood flow relation between hepatic artery and portal vein. Science Wash. DC 150: 1030-1031, 1965.
29. Thompson, A. M., H. M. Cavert, and N. Lifson. Kinetics of distribution of D20 and antipyrine in isolated perfused rat liver. Am. J. Physiol. 192: 531-537, 1958.
30. Weisiger, R. A., J. G. Fitz, and B. F. Scharschmidt. Hepatic oleate uptake. Electrochemical driving forces in intact rat liver. J. Clin. Invest. 83: 411-420, 1989.
31. Wright, T. L., P. Brissot, W. L. Ma, and R. A. Weisiger. Characterization of non-transferrin-bound iron clearance by rat liver. J. Biol. Chem. 261: 10909-10914, 1986.
32. Yamamoto, K., I. Sherman, M. J. Phillips, and M. M. Fisher. Three-dimensional observations of the hepatic arterial terminations in rat, hamster and human liver by scanning electron microscopy of microvascular casts. Hepatology 5: 452-456, 1985.