Risks and benefits of drugs used in the management of postoperative nausea and vomiting

Drug Safety

Volumn 14, Issue 3, 1996, Pages 181-197

  Sung, Yung Fong ^a  

^a EMORY CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEMETIC AGENT; CYCLIZINE; DROPERIDOL; EPHEDRINE; GRANISETRON; METOCLOPRAMIDE; NITROUS OXIDE; ONDANSETRON; PERPHENAZINE; PROCHLORPERAZINE; PROMETHAZINE; PROPOFOL; SCOPOLAMINE; SEROTONIN 3 ANTAGONIST; SEROTONIN ANTAGONIST; TROPISETRON;

ACUPUNCTURE; AMNESIA; BRADYCARDIA; CARDIOVASCULAR EFFECT; CONFUSION; CONSTIPATION; DISORIENTATION; DROWSINESS; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG SAFETY; EXTRAPYRAMIDAL SYNDROME; EXTRASYSTOLE; FATIGUE; GINGER; HUMAN; HYPOTENSION; NAUSEA; NOSE CONGESTION; POSTOPERATIVE CARE; PRIORITY JOURNAL; RESPIRATION DEPRESSION; RESTLESSNESS; REVIEW; RISK BENEFIT ANALYSIS; SEDATION; SIDE EFFECT; TACHYCARDIA; TREMOR; URINE RETENTION; VISUAL IMPAIRMENT; VOMITING; XEROSTOMIA;

EID: 0029926354     PISSN: 01145916     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002018-199614030-00005     Document Type: Review

References (140)

1. Beattie WS, Lindblad T, Buckley DN, et al. Menstruation increases the risk of nausea and vomiting after laparoscopy: a prospective randomized study. Anesthesiology 1993; 78: 272-6
2. Ramsay TM, McDonald PF, Fragher ED. The menstrual cycle and nausea and vomiting after wisdom teeth extraction. Can J Anaesth 1994; 41: 798-801
3. Buckley DN, Beattie WS, Beattie AE. Risk factors in postoperative nausea and vomiting. Anesthesiology 1993; 79: A1092
4. Honkavaara P, Lehtinen AM, Hovorka J, et al. Nausea and vomiting after gynaecological laparoscopy depends upon the phase of the menstrual cycle. Can J Anaesth 1991; 38: 876-9
5. Kauste A, Tuominen M, Heikkinen H, et al. Droperidol, alizapride and metoclopramide in the prevention of postoperative emetic sequelae. Eur J Anaesthesiol 1986; 3: 1-9
6. Madej TH, Simpson KH. Comparison of the use of domperidone, droperidol and metoclopramide in the prevention of nausea and vomiting following major gynaecological surgery. Br J Anaesth 1986; 58: 884-7
7. Kenny GNC, Oates JDL, Lesser J, et al. Efficacy of orally administered ondansetron in the prevention of postoperative nausea and vomiting: a dose ranging study. Br J Anaesth 1992; 68: 466-70
8. 3 receptor antagonist, in the prevention of postoperative nausea and vomiting after major gynaecological surgery performed under general anaesthesia. Anaesthesia 1993; 48: 214-8
9. Knapp MR, Beecher HK. Postanesthetic nausea, vomiting and retching. JAMA 1956; 160: 376-85
10. Smessaert A, Schehr CA, Artusio JF. Nausea and vomiting in the immediate postanesthetic period. JAMA 1959; 170: 2072-6
11. Purkis IE. Factors that influence postoperative vomiting. Can Anaesth Soc J 1964; 11: 335-53
12. Zelcer J, Wells DG. Anaesthetic-related recovery room complications. Anaesth Intensive Care 1987; 15: 168-74
13. Abramowitz MD, Oh TH, Epstein BS, et al. The antiemetic effect of droperidol following outpatient strabismus surgery in children. Anesthesiology 1983; 59: 579-83
14. Hardy JF, Charest J, Girouard G, et al. Nausea and vomiting after strabismus surgery in preschool children. Can Anaesth Soc J 1986; 33: 57-62
15. Lerman J, Eustis S, Smith DR. Effect of droperidol pretreatment on postanesthetic vomiting in children undergoing strabismus surgery. Anesthesiology 1986; 65: 322-5
16. Gold BS, Kitz DS, Lecky JH, et al. Unanticipated admission to the hospital following ambulatory surgery. JAMA 1989; 262: 3008-10
17. Meridy HW. Criteria for selection of ambulatory surgical patients and guidelines for anesthetic management: a retrospective study of 1553 cases. Anesth Analg 1982; 61: 921-6
18. Palazzo MG, Strunin L. Anesthesia and emesis. I. Etiology. Can Anaesth Soc J 1984; 31: 178-87
19. Keats AS. Preoperative use of antiemetics [editorial]. Anesthesiology 1960 Mar-Apr: 213
20. Clarke RSJ, Dundee JW, Love WJ. Studies of drugs given before anaesthesia VIII: Morphine 10mg alone and with atropine or hyoscine. Br J Anaesth 1965; 37: 772-7
21. Dundee JW, Moore J, Clarke RSJ. Studies of drugs given before anaesthesia V: pethidine 100mg alone and with atropine or hyoscine. Br J Anaesth 1964; 36: 703-10
22. Clissold SP, Heel RC. Transdermal hyoscine (scopolamine): a preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs 1985; 29: 189-207
23. Putcha L, Cintrón, Tsui J, et al. Pharmacokinetics and oral bioavailability of scopolamine in normal subjects. Pharm Res 1989; 6: 481-5
24. Pihlajamäki KK, Kanto JH, Oksman-Caldenley K-M. Pharmacokinetics and clinical effects of scopolamine in caesarean section patients. Acta Pharm Tox 1986; 59: 259-62
25. Muir C, Metcalfe R. A comparison of plasma levels of hyoscine alter oral and transdermal administration. J Pharm Biomed Anal 1983; 1: 363-7
26. Rowbotham DJ. Current management of postoperative nausea and vomiting. Br J Anaesth 1992; 69 Suppl. 1: 46-59
27. Reinhart DJ, Klein KW, Schroff B. Transdermal scopolamine tor the reduction of postoperative nausea in outpatient ear surgery: a double-blind, randomized study. Anesth Analg 1994 Sep-Aug; 79(2): 281-4
28. Sohi HS, Heipel J, Inman KJ, et al. Preoperative transdermal scopolamine does not reduce the level of nausea and frequency of vomiting after laparoscopic cholecystectomy. Can J Surg 1994 Aug; 37 (4): 307-12
29. Doyle E, Byers G, McNicol LR, et al. Prevention of postoperative nausea and vomiting with transdermal hyoscine in children using patient-controlled analgesia. Br J Anaesth 1994 Jan; 72 (1): 72-6
30. Bailey PL, Streisand JB, Pace NL, et al. Transdermal scopolamine reduces nausea and vomiting after outpatient laparoscopy. Anesthesiology 1990 Jun; 72 (6): 977-80
31. Horimoto Y, Tomie H, Hanzawa K, et al. Scopolamine patch reduces postoperative emesis in paediatric patients following strabismus surgery. Can J Anaesth 1991; 38 (4): 441-1
32. Baldessarini RJ. Drugs and the treatment of psychiatric disorders. In: Gilman AG, Goodman LS, Rall TW, et al., editors. The pharmacological basis of therapeutics. New York: Pergamon Press, 1990; 383-435
33. Blanc VF, Ruest P, Milot J, et al. Antiemetic prophylaxis with promethazine or droperidol in paediatric outpatient strabismus surgery. Can J Anaesth 1991; 38: 54-60
34. Wood CD, Graybeil A. The antimotion sickness drugs. Otolaryngol Clin North Am 1973; 6 (1): 301-3
35. Wood CD. Antimotion sickness and antiemetic drugs. Drugs 1979; 17: 471-9
36. Davis JR, Jennings RT, Beck BG, et al. Treatment efficacy of intramuscular promethazine for space motion sickness. Aviat Space Environ Med 1993 Mar; 64 (3 Pt 1): 230-3
37. Garrison JC. Histamine bradykinin, 5-hydroxytryptamine, and their antagonist. In: Gilman AG, Rall TW, Nies AS, et al., editors. The pharmacological basis of therapeutics. New York: Pergamon Press; 1990: 575-99
38. Buzdar Au, Esparza L, Natale R, et al. Lorazepam-enhancement of the antiemetic efficacy of dexamethasone and promethazine. A placebo-controlled study. Am J Clin Oncol 1994 Oct; 17 (5): 417-21
39. Walder AD, Aitkenhead AR. A comparison of droperidol and cyclizine in the prevention of postoperative nausea and vomiting associated with patient-controlled analgesia. Anaesthesia 1995 Jul; 50 (7): 654-6
40. Synder SH, U'Prichard D, Greenberg DA. Neurotransmiuer receptor binding in the brain. In: Lipton MA, DiMascio A, Killam KF, editors. Psychopharmacology: a generation of progress. New York: Raven Press, 1978: 361-70
41. Hanson CE, Christensen TR, Elley J, et al. Clinical pharmacokinetic studies of perphenazine. Br J Clin Pharmacol 1976; 3: 915-23
42. Bradley BE, Moore DC. The use of intramuscular perphenazine to control postoperative vomiting. Am J Surg 1961 Jul; 102: 120-3
43. Lind B, Breivik H. Metoclopramide and perphenazine in the prevention of postoperative nausea and vomiting; a double blind comparison. Br J Anaesth 1970; 42: 614-7
44. McGarry JM. A double-blind comparison of the anti-emetic effect during labour of metoclopramide and perphenazine. Br J Anaesth 1971; 43: 613
45. Robbie DS. Postanaesthetic vomiting and anti-emetic drugs. Anaesthesia 1959; 14: 349-54
46. Scurr CF, Robbie DS. Trials of perphenazine in the prevention of postoperative vomiting. BMJ 1958; 1: 922-3
47. Desilva PH, Darvish AH, McDonald SM, et al. The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. Anesth Analg 1995 Jul; 81 (1): 139-43
48. Cramb R, Fargas-Babjak A, Hirano G. Intraoperative proclorperazine for prevention of postoperative nausea and vomiting. Can J Anaesth 1989 Sep; 36 (5): 565-7
49. Patterson KW, Armstrong C, Timon D, et al. Buccal prochlorperazine as an antiemetic for day care surgery. Ir Med J 1993 Nov-Dec; 86 (6): 186-8
50. Loeser EA, Bennett G, Stanley TH, et al. Comparison of droperidol, haloperidol and prochlorperazine as postoperative anti-emetics. Can Anaesth Soc J 1979 Mar; 26 (2): 125-7
51. Melnick BM. Extrapyramidal reactions to low-dose droperidol. Anesthesiology 1988 Sep; 69 (3): 424-6
52. Kennedy SK, Longnecker DE. History and principles of anesthesiology. In: Gilman AG, Goodman LS, Rall TW, et al., editors. The pharmacological basis of therapeutics. New York: Pergamon Press, 1990: 269-84
53. Melnick B, Sawyer R, Karambelkar D, et al. Delayed side effects of droperidol after ambulatory general anesthesia. Anesth Analg 1989; 69: 748-51
54. Winning TJ, Brock-Utne JG, Downing JW. Nausea and vomiting after anesthesia and minor surgery. Anesth Analg 1977; 56: 674-7
55. Iwamoto K, Schwartz H. Antiemetic effect of droperidol after ophthalmic surgery. Arch Ophthalmol 1978 Aug; 96 (8): 1378-9
56. Rita L, Goodarzi M, Seleny F. Effect of low dose droperidol on postoperative vomiting in children. Can Anaesth Soc J 1981 May; 28 (3): 259-62
57. Eustis S, Lerman J, Smith DR. Effect of droperidol pretreatment on post-anesthetic vomiting in children undergoing strabismus surgery: the minimum effective dose. J Pediatr Ophthalmol Strabismus 1987 Jul-Aug; 24 (4): 165-9
58. Mortensen PT. Droperidol (Dehydrobenzperidol®): postoperative anti-emetic effect when given intravenously to gynaecological patients. Acta Anaesthesiol Scand 1982; 26: 48-52
59. Wetchler BV, Collins IS, Jacob L. Antiemetic effects of droperidol on the ambulatory surgery patient. Anesth Rev 1982 May; 9 (5): 23-6
60. Patton CM, Moon MR, Dannemiller FJ. The prophylactic anti-emetic effect of droperidol. Anesth Analg 1974 May-Jun; 53 (3): 361-4
61. McKenzie R, Wadhwa RK, Uy NTL, et al. Antiemetic effectiveness of intramuscular hydroxyzine compared with intramuscular droperidol. Anesth Analg 1981 Nov; 60(11): 783-8
62. Gan TJ, Alexander R, Fennelly M, et al. Comparison of different methods of administering droperidol in patient-controlled analgesia in the prevention of postoperative nausea and vomiting. Anesth Analg 1995; 80: 81-5
63. Pinder RM, Brogden RN, Sawyer PR, et al. Metoclopramide: a review of its pharmacological properties and clinical use. Drugs 1976; 12: 81-131
64. Harrington RA, Hamilton CW, Brogden RN, et al. Metoclopramide: an updated review of its pharmacological properties and clinical use. Drugs 1983; 25: 451-94
65. Andrew PL, Rapeport WG, Sanger GJ. Neuropharmacology of emesis induced by anti-cancer therapy. Trends Pharmacol Sci 1988 Sep; 9 (9): 334-41
66. Ross-Lee LM, Hooper WD, Bochner F. Single-dose pharmacokinetics of metoclopramide. Eur J Clin Pharmacol 1981; 20: 465-71
67. Bateman DN, Kahn C, Davies DS. The pharmacokinetics of metoclopramide in man with observations in the dog. Br J Clin Pharmacol 1980; 9: 371-7
68. Teng L, Bruce RB, Dunning LK. Metoclopramide metabolism and determination by high-pressure liquid chromatography. J Pharm Sci 1977; 66 (11): 1615-8
69. Graffner C, Lagerström PO, Lundborg P, et al. Pharmacokinetics of metoclopramide intravenously and orally determined by liquid chromatography. Br J Clin Pharmacol 1979; 8 (5): 469-74
70. Bateman DN, Kahn C, Davies DS. Concentration effect studies with oral metoclopramide. Br J Clin Pharmacol 1979 Aug: 8 (2): 179-82
71. Goslin RH, Garnick MB. Metoclopramide as an antiemetic in patients receiving cisplatin. In: Poster DS, Penta JS, Bruno S, editors. Treatment of cancer chemotherapy-induced nausea and vomiting. New York: Masson Press, 1981: 159-65
72. Grimes JD, Hassan MN, Preston DN. Adverse neurologic effects of metoclopramide. Can Med Assoc J 1982 Jan 1; 126 (1): 23-5
73. McCallum RW, Ippoliti AF, Cooner C, et al. A controlled trial of metoclopramide in symptomatic gastroesophageal reflux. N Engl J Med 1977; 296 (7): 354-7
74. Desmond PV, Watson KJR. Metoclopramide - a review. Med J Aust 1986 Mar 31; 144: 366-9
75. Schulze-Delrieu K. Metoclopramide. Drug therapy. N Engl J Med 1981 Jul 2; 305 (1): 28-33
76. Lin DM, Furst SR, Rodarte A. A double-blinded comparison of metoclopramide and droperidol for prevention of emesis following strabismus surgery. Anesthesiology 1992; 76: 357-61
77. Broadman LM, Ceruzzi W, Patane PS, et al. Metoclopramide reduces the incidence of vomiting following strabismus surgery in children. Anesthesiology 1990; 72: 245-8
78. Cohen SE, Woods WA, Wyner J. Antiemetic efficacy of droperidol and metoclopramide. Anesthesiology 1984 Jan; 60 (1): 67-9
79. Madej TH, Simpson KH. Comparison of the use of domperidone, droperidol and metoclopramide in the prevention of nausea and vomiting following gynaecological surgery in day cases. Br J Anaesth 1986; 58: 879-83
80. Korttila K, Kauste A, Auvinen J. Comparison of domperidone, droperidol, and metoclopramide in the prevention and treatment of nausea and vomiting after balanced general anesthesia. Anesth Analg 1979 Sep-Oct; 58 (5): 396-400
81. Raphael JH, Norton AC. Antiemetic efficacy of prophylactic ondansetron in laparoscopic surgery: randomized, double-blind comparison with metoclopramide. Br J Anaesth 1993; 71: 845-8
82. Bunce KT, Tyers MB. The rule of 5-HT in postoperative nausea and vomiting. Br J Anaesth 1992; 69 Suppl. 1: 60-2
83. Markham A, Sorkin EM. Ondansetron: an update of its therapeutic use in chemotherapy-induced and postoperative nausea and vomiting. Drugs 1993; 45 (6): 931-52
84. Saynor DA, Dixon CM. The metabolism of ondansetron. Eur J Cancer Clin Oncol 1989; 25 Suppl. 1: 75-7
85. Blackwell CP, Harding SM. The clinical pharmacology of ondansetron. Eur J Cancer Clin Oncol 1989; 25 Suppl. 1: 21-4
86. Chaffee BJ, Tankanow RM. Ondansetron: the first of a new class of antiemetic agents. Clin Pharm 1991; 10: 430-46
87. Baber N, Palmer JL, Frazer NM, et al. Clinical pharmacology of ondansetron in postoperative nausea and vomiting. Eur J Anaesth 1992; 9 Suppl. 6: 11-8
88. Pritchard JF, Bryson JC, Kernodle AE, et al. Age and gender effects on ondansetron pharmacokinetics: evaluation of healthy aged volunteers. Clin Pharmacol Ther 1992; 51: 51-5
89. Dershwitz M, Di Biase PM, Rosow CE, et al. Ondansetron does not affect alfentanil-induced ventilatory depression or sedation. Anesthesiology 1992 Sep; 77 (3): 447-52
90. McKenzie R, Kovac A, O'Connor T, et al. Comparison of ondansetron versus placebo to prevent postoperative nausea and vomiting in women undergoing ambulatory gynecologic surgery. Anesthesiology 1993; 78: 21-8
91. Sung Y-F, Wetchler BV, Duncalf D, et al. A double-blind placebo-controlled pilot study examining the effectiveness of intravenous ondansetron in the prevention of postoperative nausea and emesis. J Clin Anesth 1993; 5: 22-9
92. Khalil SN, Kataria B, Pearson K, et al. Ondansetron prevents postoperative nausea and vomiting in women outpatients. Anesth Analg 1994; 79: 845-51
93. Bodner M, White PK. Antiemetic efficacy of ondansetron after outpatient laparoscopy. Anesth Analg 1991; 73: 250-4
94. 3 antagonist ondansetron. Anesthesiology 1993 Jan; 78 (1): 15-20
95. Rodrigo MRC, Campbell RCH, Chow J, et al. Ondansetron for prevention of postoperative nausea and vomiting following minor oral surgery: a double-blind randomized study. Anaesth Intensive Care 1994; 22: 576-9
96. Fursi SR, Rodart A. Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. Anesthesiology 1994 Oct; 81 (4): 799-803
97. Watcha MF, Bras PJ, Cieslak GD, et al. The dose-response relationship of ondansetron in preventing postoperative emesis in pediatric patients undergoing ambulatory surgery. Anesthesiology 1995 Jan; 82 (1): 47-52
98. Ummenhofer W, Frei FJ, Urwyler A, et al. Effects of ondansetron in the prevention of postoperative nausea and vomiting in children. Anesthesiology 1994 Oct; 81 (4): 804-10
99. Carroll NV, Miederhoff P, Cox FM, et al. Postoperative nausea and vomiting after discharge from outpatient surgery centers. Anesth Analg 1995; 80: 903-9
100. Claybon L. Single dose intravenous ondansetron for the 24-hour treatment of postoperative nausea and vomiting. Anaesthesia 1994; 49 Suppl.: 24-9
101. Pearman MH. Single dose intravenous ondansetron in the prevention of postoperative nausea and vomiting. Anaesthesia 1994; 49 Suppl.: 11-5
102. Grond S, Lynch J, Diefenbach C, et al. Comparison of ondansetron and droperidol in the prevention of nausea and vomiting after inpatient minor gynecologic surgery. Anesth Analg 1995 Sep; 81 (3): 603-7
103. Paxton LD, McKay AC, Mirakhur RK. Prevention of nausea and vomiting after day care gynaecological laparoscopy. A comparison of ondansetron, droperidol, metoclopramide and placebo. Anaesthesia 1995 May: 50 (5): 403-6
104. Litman RS, Wu CL, Lee A, et al. Prevention of emesis after strabismus repair in children: a prospective, double-blinded, randomized comparison of droperidol versus ondansetron. J Clin Anesth 1995 Feb; 7(1): 58-62
105. Gan TJ, Collis R, Hetreed M. Double-blind comparison of ondansetron, droperidol and saline in the prevention of postoperative nausea and vomiting. Br J Anaesth 1994; 72: 544-7
106. Lewis MA, Fishman DA. Ondansetron for postoperative nausea and vomiting: decisions in the absence of comparative trials. Am J Hosp Pharm 1994 Feb; 51: 524-5
107. Mikawa K, Takao Y, Nishina K, et al. The antiemetic efficiacy of prophylactic granisetron in gynecologic surgery. Anesth Analg 1995 May; 80 (5): 970-4
108. Fujii Y, Tanaka H, Toyooka H. Optimal anti-emetic dose of granisetron for preventing postoperative nausea and vomiting. Can J Anaesth 1994 Sep; 41 (9): 794-7
109. Zomers PJ, Langenberg CJ, de Bruijn KM. Tropisetron for postoperative nausea and vomiting in patients after gynaecological surgery. Br J Anaesth 1993 Nov; 71 (5): 677-80
110. Schreiner MS, Nicolson SC, Martin T, et al. Should children drink before discharge from day surgery? Anesthesiology 1992 Apr; 76 (4): 528-33
111. Kamath B, Curran J, Hawkey C, et al. Anaesthesia, movement and emesis. Br J Anesth 1990; 64: 728-30
112. Kraynack BJ, Bates MF, Ginautas J. Antiemetic efficacy of ranitidine, metoclopramide and gastric suctioning in outpatient laparoscopy. Anesth Analg 1990; 70 Suppl.: 218
113. McCarroll SM, Mori S, Bras PJ, et al. The effect of gastric-intubation and removal of gastric contents on the incidence of postoperative nausea and vomiting. Anesth Analg 1990; 70 Suppl.: 262
114. Hovorka J, Korttila K, Erkola O. Gastric aspiration at the end of anaesthesia does not decrease postoperative nausea and vomiting. Anaesth Intensive Care 1990; 18: 58-61
115. Lonie DS, Harper NJN. Nitrous oxide anaesthesia and vomiting. Anaesthesia 1986; 41: 703-7
116. Melnick BM, Johnson LS. Effects of eliminating nitrous oxide in outpatient anesthesia. Anesthesiology 1987 Dec; 67 (6): 982-4
117. Felts JA, Poler SM, Spitznagel EL. Nitrous oxide, nausea, and vomiting after outpatient gynecologic surgery. J Clin Anesth 1990 May-Jun; 2: 168-71
118. Muir JJ, Warner MA, Offord KP, et al. Role of nitrous oxide and other factors in postoperative nausea and vomiting: a randomized and blinded prospective study. Anesthesiology 1987 Apr; 66 (4): 513-8
119. Korttila K, Hovorka J, Erkola O. Nitrous oxide does not increase the incidence of nausea and vomiting after isoflurane anesthesia. Anesth Analg 1987; 66: 761-5
120. Sengupta P, Plantevin OM. Nitrous oxide and day-case laparoscopy: effects on nausea, vomiting and return to normal activity. Br J Anaesth 1988; 60: 570-3
121. Hovorka J, Korttila K. Nitrous oxide does not increase nausea and vomiting following gynaecological laparoscopy. Can J Anaesth 1989; 36 (2): 145-8
122. Borgeat A. Effects of diprivan on nausea and vomiting [in French]. Ann Fr Anesth Reanim 1994; 13 (4): 576-8
123. Ostman PL, Faure E, Glosten B, et al. Is the antiemetic effect of the emulsion formulation of propofol due to the lipid emulsion? Anesth Analg 1990 Nov: 71 (5): 536-40
124. Wagner BK, Berman SL, Devitt PA, et al. Retrospective analysis of postoperative nausea and vomiting to determine anti-emetic activity of droperidol added to propofol: a possible drug interaction. Pharmacotherapy 1994 Sep-Oct; 14 (5): 586-91
125. Kohl RL, Calkins DS, Mandell AJ. Arousal and stability: the effects of five new sympathomimetic drugs suggest a new principle for the prevention of space motion sickness. Aviat Space Environ Med 1986 Feb; 57 (2): 137-43
126. Rothenberg DM, Parnass SM, Litwack K, et al. Efficacy of ephedrine in the prevention of postoperative nausea and vomiting. Anesth Analg 1991; 72: 58-61
127. Liu Y-C, Kang H-M, Liou C-M, et al. Comparison of antiemetic effect among ephedrine, droperidol and metoclopramide in pediatric inguinal hernioplasty. Acta Anaesthesiol Sin 1992; 30 (1): 37-42
128. Dundee JW, Chestnutt WN, Ghaly RB, et al. Traditional Chinese acupuncture: a potentially useful antiemetic? BMJ 1986 Sept 6; 293: 583-4
129. Ho RT, Jawan B, Fung ST, et al. Electro-acupuncture and postoperative emesis. Anesthesia 1989; 45: 327-9
130. Yentis SM, Bissonnette B. P6 acupuncture and postoperative vomiting after tonsillectomy in children. Br J Anaesth 1991; 67: 779-80
131. Lewis IH, Pryn SJ, Reynolds PI, et al. Effect of P6 acupressure on postoperative vomiting in children undergoing outpatient strabismus correction. Br J Anaesth 1991; 67: 73-8
132. Mowrey DB, Clayson DE. Motion sickness, ginger, and psychophysics. Lancet 1982 Mar; 20: 655-6
133. Grontved A, Brask T, Kambskard J, et al. Ginger root against seasickness. A controlled trial on the open sea. Acta Otolaryngol 1988 Jan-Feb; 105 (1-2): 45-9
134. Stewart JJ, Wood MJ, Wood CD, et al. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 1991; 42(2): 111-20
135. Phillips S, Ruggier R, Hutchinson SE. Zingiber officinale (ginger) - an antiemetic for day case surgery. Anaesthesia 1993 Aug; 48 (8): 715-7
136. Michaloudis D, O'Keeffe N, O'Sullivan K, et al. Postoperative nausea and vomiting: a comparison of anti-emetic drugs used alone or in combination. J R Soc Med 1993 Mar; 86: 137-8
137. McKenzie R, Tantisira B, Karambelkar DJ, et al. Comparison of ondansetron with ondansetron plus dexamethasone in the prevention of postoperative nausea and vomiting. Anesth Analg 1994; 79: 961-4
138. Doze VA, Shafer A, White PF. Nausea and vomiting after outpatient anesthesia: effectiveness of droperidol alone and in combination with metoclopramide. Anesth Analg 1987; 66 Suppl.: S41
139. Pandit SK, Kothary SP, Pandit UA, et al. Dose-response study of droperidol and metoclopramide as antiemetics for outpatient anesthesia. Anesth Analg 1989; 68: 798-802
140. Kris MG, Gralla RJ, Clark RA, et al. Antiemetic control and prevention of side effects of anti-cancer therapy with lorazepam or diphenhydramine when used in combination with metoclopramide plus dexamethasone. Cancer 1987 Dec; 60 (11): 2816-22