Co-administration of ethanol transiently inhibits urethane genotoxicity as detected by a kinetic study of micronuclei induction in mice

Mutation Research - Genetic Toxicology

Volumn 367, Issue 4, 1996, Pages 237-244

  Choy, Wai Nang ^a   Mandakas, George ^a   Paradisin, William ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bone marrow micronucleus assay; Ethanol; Peripheral blood micronucleus assay; Risk assessment; Urethane (ethyl carbamate)

Indexed keywords

ALCOHOL; URETHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CHEMICAL INTERACTION; CONTROLLED STUDY; GENOTOXICITY; KINETICS; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029926222     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(96)90083-X     Document Type: Article

References (40)

1. Allen, J.W., Y. Sharief and R.J. Langenbath (1982) An overview of ethyl carbamate (urethane) and its genotoxic activity, in: R.R. Tice, D.L. Costa and K.M. Schaich (Eds.), Genotoxic Effects of Airborne Agents, Plenum Press, New York, pp. 443-460.
2. Altmann, H.J., B. Dusemund, M. Goll and W. Grunow (1991) Effect of ethanol on the induction of lung tumours by ethyl carbamate in mice. Toxicology, 68, 195-201.
3. Ashby, J., H. Tinwell and R.D. Callander (1990) Activity of urethane and N,N-dimethylurethane in the mouse bone-marrow micronucleus assay: Equivalence of oral and intraperitoneal routes of exposure, Mutation Res., 245, 227-230.
4. Bateman, A.J. (1976) The mutagenic action of urethane, Mutation Res., 39, 75-96.
5. Burke, D.A., D.J. Wedd, D. Herriott, M.K. Bayliss, D.J.M. Spalding and P. Wilcox (1994) Evaluation of pyrazole and ethanol induced S9 fraction in bacterial mutagenicity testing, Mutagenesis, 9, 23-29.
6. CDHS (California Department of Health Services) (1990) Risk-specific intake levels for the Proposition 65 carcinogen: Urethane, Reproductive and Cancer Hazard Assessment Section, Office of Environmental Health Hazard Assessment. California Department of Health Services, Berkeley, CA.
7. Choy, W.N. (1991) Genotoxicity, in: A.G. Salmon and L. Zeise (Eds.), Risks of Carcinogenesis from Urethane Exposure, CRC Press, Boca Raton, FL. pp. 28-27.
8. Choy, W.N., W. Black, G. Mandakas, E.J. Mirro and H.E. Black (1995) A pharmacokinetic study of ethanol inhibition of micronuclei induction by urethane in mouse bone marrow erythrocytes, Mutation Res., 341, 255-263.
9. Crump, K.S. (1981) An improved procedure for low-dose carcinogenic risk assessment from animal data, J. Environ. Pathol. Toxicol., 52, 675-684.
10. Crump, K.S., H.A. Guess and L.L. Deal (1977) Confidence intervals and test of hypotheses concerning dose-response relations inferred from animal carcinogenicity data. Biometrics, 33, 437-451.
11. CSGMT (Collaborative Study Group for the Micronucleus Test) (1992) Micronucleus test with rodent peripheral blood reticulocytes by acridine orange supravital staining. Mutation Res., 278, 81-213.
12. Dunn, A.J., A.G. Salmon and L. Zeise (1991) Background, in: A.G. Salmon and L. Zeise (Eds.), Risks of Carcinogenesis from Urethane Exposure, CRC Press, Boca Raton, FL, pp. 4-9.
13. 6-ethenoadenosine, Chem. Res. Toxicol., 4, 413-421.
14. Guengerich P.P., D.H. Kim and M. Iwasaki (1991) Role of human cytochrome P-450IIE1 in the oxidation of many low molecular weight cancer suspects, Chem. Res. Toxicol., 4, 168-179.
15. Hayashi, M., T. Sofuni and M. Ishidate Jr. (1983) An application of acridine orange fluorescent staining to the micronucleus test, Mutation Res., 120, 241-247.
16. Holmstrom, M. (1990) Induction of micronuclei in bone marrow of mice exposed to 1, 2 or 3 daily doses of urethane, Mutation Res., 234, 147-154.
17. IARC (International Agency for Research on Cancer) (1974) Some antithyroid and related substances, nitrofurans and industrial chemicals, in: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 7, IARC, Lyon, France.
18. IARC (International Agency for Research on Cancer) (1987) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Suppl. 7, IARC, Lyon, France.
19. Kishi, M., Y. Horiguchi, S. Watanabe and M. Hayashi (1994) Validation of the mouse peripheral blood micronucleus assay using acridine orange supravital staining with urethane, Mutation Res., 278, 205-208.
20. Kristiansen, E., S. Clemmensen and O. Meyer (1990) Chronic ethanol intake and reduction of lung tumours from urethane in strain A mice, Fd. Chem. Toxicol., 28, 35-38.
21. Kurata, N., H.E. Hurst, F.W. Benz, R.A. Kemper and W.J. Waddell (1991) Studies on inhibition and induction of metabolism of ethyl carbamate by acetone and related compounds, evidence for metabolism by cytochromes P-450, Drug Metab. Dispos., 19, 388-393.
22. MacGregor J.T., C.M. Wehr and D.H. Could (1980) Clastogen-induced micronuclei in peripheral blood erythrocytes: the basis of an improved micronucleus test, Environ. Mutagen., 2, 509-514.
23. Mavournin, K.H., D.H. Blakey, M.C. Cimino, M.F. Salamone and J.A. Heddle (1990) The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutation Res., 239, 29-80.
24. Nomeir, A.A., Y.M. Loannou, J.M. Sanders and H.B. Matthews (1989) Comparative metabolism and disposition of ethyl carbamate (urethane) in male Fischer 344 rats and male B6C3F1 mice. Toxicol. Appl. Pharmacol, 97, 203-215.
25. NTP (National Toxicology Program) (1988) Urethane Background Information and Testing Recommendations. Carcinogenesis and Toxicology Evaluation Branch.
26. Odagiri, Y., S. Adachi, H, Katayama and K. Takemoto (1986) Detection of the cytogenetic effect of inhaled aerosols by the micronucleus test, Mutation Res., 170, 79-83.
27. Ough, C.S. (1976) Ethyl carbamate in fermented beverages and foods. I. Naturally occurring ethyl carbamate, J. Agri. Fd. Chem., 24, 323-328.
28. Park, K.K., A. Liem, C.S., B.C. Steward and J.A. Miller (1993) Vinyl carbamate epoxide, a major strong electrophilic, mutagenic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate (urethane), Carcinogenesis, 14, 441-450.
29. Salmon A.G., P. Painter, A.J. Dunn, A.Wu-Williams, L. Monserrat and L. Zeise (1991) Carcinogenic effects, in: A.G. Salmon and L. Zeise (Eds.), Risks of Carcinogenesis from Urethane Exposure. CRC Press, Boca Raton, FL, pp. 48-77.
30. Sanderson, B.J.S. and A.M. Clark (1993) Micronuclei in adult and foetal mice exposed in vivo to heliotrine, urethane, monocrotaline and benzidine, Mutation Res., 285, 27-33.
31. Stoewsand, G.S., J.L. Anderson and L. Munson (1991) Inhibition by wine of tumorigenesis induced by ethyl carbamate (urethane) in mice, Fd. Chem. Toxicol., 29, 291-295.
32. Waddell, W.J., C. Marlowe and W.M. Pierce, Jr. (1987) Inhibition of the localization of urethane in mouse tissues by ethanol. Fd. Chem. Toxicol., 25, 527-531.
33. Westmoreland, C., M. Plumstead and D. Gatehouse (1991) Activity of urethane in rat and mouse micronucleus tests after oral administration, Mutation Res., 262, 247-251.
34. Wild, D. (1978) Cytogenetic effects in the mouse of 17 chemical mutagens and carcinogens evaluated by the micronucleus tests, Mutation Res., 56, 319-327.
35. Wild, D. (1991) Micronucleus induction in bone marrow by vinyl carbamate, a hypothetical metabolite of the carcinogen urethane (ethyl carbamate), Mutation Res., 260, 309-310
36. Wilkinson, P.K. (1976) Blood ethanol concentrations during and following constant rate IV infusion of alcohol, Clin. Pharmacol. Ther., 19, 213.
37. Yamamoto, T., W.M. Pierce, Jr, H.E. Hurst, D. Chen and W.J. Waddell (1988) Inhibition of the metabolism of urethane by ethanol, Drug Metab. Dispos., 16, 355-358.
38. Yamamoto, T., W.M. Pierce. Jr., H.E. Hurst, D. Chen and W.J. Waddell (1990) Ethyl carbamate metabolism: In vivo inhibitors and in vitro enzymatic systems, Drug Metab. Dispos., 18, 276-289.
39. Zeise, L., A.G. Salmon, T. McDonald and P. Painter (1991) Cancer potency estimation, in: A.G. Salmon and L. Zeise (Eds.), Risks of Carcinogenesis from Urethane Exposure, CRC Press, Boca Raton, FL, pp. 96-111.
40. Zimmerli, B. and J. Schlatter (1991) Ethyl carbamate: analytical methodology, occurrence, formation, biological activity and risk assessment, Mutation Res., 259, 325-350.