Cartesian coordinate analysis of viral burden and CD4+ cell count in HIV disease: Implications for clinical trial design and analysis

Antiviral Research

Volumn 29, Issue 1, 1996, Pages 83-86

  Reichelderfer, P S ^a   Coombs, R W ^b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cartesian coordinate plot; CD4+ cell; Clinical trial design; Immunologic response modifier; Individual therapy response; Viral burden; Virologic response modifier

Indexed keywords

ANTIVIRUS AGENT; CD4 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CLINICAL PROTOCOL; CLINICAL TRIAL; CONFERENCE PAPER; DRUG RESPONSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; T LYMPHOCYTE; TECHNIQUE; VIRUS CONCENTRATION;

EID: 0029926054     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-3542(95)00924-8     Document Type: Conference Paper

References (10)

1. Cavert, W., Coombs, R.W., Grimes, J., Kuritzkes, D., Johnson, V., Kappes, J., Stein, D., Beatty, C., Erice, A., Winters, M., Katzenstein, D., Johnson, E., Rojo, E., Mirabile, M., Elbeik, T., Tsiatis, B. and Corey, L. (1995) The therapeutic significance of switching to ddI or adding ddI in subjects with ZDV resistant HIV-1, 4th International Workship on HIV Drug Resistance, pp. 41. Sardinia, Italy.
2. Coffin, J.M. (1995) HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267, 483-489.
3. de Boer, R.J. and Boerlijst, M.C. (1994) Diversity and virulence thresholds in AIDS. Proc. Natl. Acad. Sci. 91, 544-548.
4. Fiscus, S.A., DeGruttola, V., Gupta, P., Katzenstein, D.A., Meyer, W.A., Lafaro, M.L., Katzman, M., Ragni, M.V., Reichelderfer, P.S. and Coombs, R.W. (1995) Human immunodeficiency virus type-1 quantitative cell microculture as a measure of antiviral efficacy in a multi-center clinical trial. J. Infect. Dis. 171, 305-311.
5. Ho, D.D., Neumann, A.U., Perelson, A.S., Chen, W., Leonard, J.M. and Markowitz, M. (1995) Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123-126.
6. Hooper, C., Welles, S., D'Aquila, R., Japour, A., Johnson, V., Kuritzkes, D., Jackson, B., DeGruttola, V., Crumpacker, C. and Richman, D. (1994a) HIV-1 RNA level in plasma and assoiation with disease progression, zidovudine sensitivity phenotype and genotype, syncytium-inducing phenotype, CD4+ cell count and clinical diagnosis of AIDS. In: Third International HIV Drug Resistance Workshop, pp. 67. Kauai, Hawaii.
7. Hooper, C.J., Coombs, R.W., Yang, Y.Y., Paragas, J.J., Boutin, P.D., Collier, A.C. and Corey, L. (1994b) Association between HIV-1 inhibition and CD4 cell rise in patients on antiviral therapy, 32 Infectious Diseases Society of America, Orlando, Florida.
8. Paxton, W., Coombs, R., McElrath, J., Keefer, M., Sinangil, F., Williams, W., David Chernoff, D., Hughes, J. and Corey, L. (1995) Longitudinal analysis of quantitative virologic measures in HIV-1 infected individuals with >400 CD4+ cells/μl, Second National Conference Human Retroviruses and related infections. pp. 97. Washington, DC.
9. Schnittman, S.M., Greenhouse, J.J., Psallidopoulos, M.C., Baseler, M., Salzman, N.P., Fauci, A.S. and Lane, H.C. (1990) Increasing viral burden in CD4+ T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease. Ann. Intern. Med. 113, 438-43.
10. Wei, X., Ghosh, S.K., Taylor, M.E., Johnson, V.A., Emini, E.A., Deutsch, P., Lifson, J.D., Bonhoeffer, S., Nowak, M.A., Hahn, B.H., Saag, M.S. and Shaw, G.M. (1995) Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373, 117-122.