Muscarinic receptor reserve for inhibition of cAMP accumulation in bovine trachealis cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 270, Issue 2 14-2, 1996, Pages

  Ethier, Michael F ^a   Schaefer, Oren P ^a   Samant, Ninad ^a   Yamaguchi, Hiroshi ^a   Madison, J Mark ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

adenosine 3',5' cyclic monophosphate; airway smooth muscle; phenoxybenzamine; propylbenzylcholine mustard; radioligand binding; receptor spareness

Indexed keywords

CARBACHOL; CYCLIC AMP; ISOPRENALINE; MUSCARINIC RECEPTOR; PHENOXYBENZAMINE; PROPYLBENZILOYLCHOLINE MUSTARD; QUINUCLIDINYL BENZILATE;

ANIMAL CELL; ARTICLE; CATTLE; CONTROLLED STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR OCCUPANCY; SMOOTH MUSCLE FIBER; TRACHEA MUSCLE;

EID: 0029926032     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1996.270.2.l199     Document Type: Article

References (44)

1. Birdsall, N. J. M., E. C. Hulme, R. Hammer, and J. S. Stockton. Subclasses of muscarinic receptors. In: Psychopharmacology and Biochemistry of Neurotransmitter Receptors, edited by H. I. Yamamura, R. Olsen, and E. Usdin. New York: Elsevier/North-Holland, 1980, p. 97-100.
2. Brichant, J.-F., D. O. Warner, S. J. Gunst, and K. Rehder. Muscarinic receptor subtypes in canine trachea. Am. J. Physiol. 258 (Lung Cell. Mol. Physiol. 2): L349-L354, 1990.
3. Brown, B. L., R. J. Wojcikiewicz, P. R. Dobson, A. Robinson, and L. I. Irons. Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on the cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumor cells. Biochem. J. 223: 145-149, 1984.
4. Brown, J. H., and S. L. Brown. Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism. J. Biol. Chem. 259: 3777-3781, 1984.
5. Brown, J. H., and D. Goldstein. Differences in muscarinic receptor reserve for inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in chick heart cells. Mol. Pharmacol. 30: 566-570, 1986.
6. 3H] quinuclidinylbenzilate binding to rat brain membranes. Mol. Pharmacol. 30: 58-68, 1986.
7. Cameron, A, R., C. G. Bullock, and C. T. Kirkpatrick. The ultrastructure of bovine tracheal smooth muscle. J. Ultrastruct. Res. 81: 290-305, 1982.
8. 50) of an enzymatic reaction. Biochem. Pharmacol. 22: 3099-3109, 1973.
9. Collins, S. M., and D. J. Crankshaw. Dissociation of contraction and muscarinic receptor binding to isolated smooth muscle cells. Am. J. Physiol. 251 (Gastrointest. Liver Physiol. 14): G546-G552, 1986
10. De Lean, A., P. J. Munson, and D. Rodbard. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol. 235 (Endocrinol. Metab. Gastrointest. Physiol. 4): E97-E102, 1978.
11. Doelman, C. J. A., and A. Bast. Oxygen radicals in lung pathology. Free Radical Biol. Med. 9: 381-400, 1990.
12. Ellis, J., and R. H. Lenox. Quaternary forms of classical muscarinic antagonists distinguish subpopulations of muscarinic receptors: correlation with gallamine-defined subpopulations. Biochem. Biophys. Res. Commun. 126: 1242-1250, 1985.
13. Feigenbaum, P., and E. E. El-Fakahany. Regulation of muscarinic cholinergic receptor density in neuroblastoma cells by brief exposure to agonist: possible involvement in desensitization of receptor function. J. Pharmacol. Exp. Ther. 233: 134-140, 1985.
14. 2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle J. Pharmacol. Exp Ther. 262: 119-126, 1992.
15. Furchgott, R. F. The use of β-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes. Adv. Drug Res. 3: 21-25, 1966.
16. Furchgott, R. F. Pharmacological characterization of receptors: its relation to radioligand-binding studies. Federation Proc. 37: 115-120, 1978.
17. Gabella, G., and L. Raeymaekers. Effect of collagenase on mechanical activity and fine structure of an intestinal smooth muscle. Cell Tissue Res. 173: 29-44, 1976.
18. Gengo, P. J., F. Yousif, R. A. Janis, and D. J. Triggle. Interaction of phenoxybenzamine with muscarinic receptors and calcium channels. Biochem. Pharmacol. 33: 3445-3449, 1984.
19. Gill, E. W., and H. P. Rang. An alkylating derivative of benzilycholine with specific and long-lasting parasympathetic activity. Mol. Pharmacol. 2: 284-297, 1966.
20. Grandordy, B. M., F. M. Cuss, A. S. Sampson, J. B. Palmer, and P. J. Barnes. Phosphatidylinositol response to cholinergic agonists in airway smooth muscle: relationship to contraction and muscarinic receptor occupancy. J. Pharmacol. Exp. Ther. 238: 273-279, 1986.
21. Gunst, S. J., J. Q. Stropp, and N. A. Flavahan. Analysis of receptor reserves in canine tracheal smooth muscle, J. Appl. Physiol. 62: 1755-1758, 1987.
22. Harden, T. K., M. M. Heng, and J. Heller Brown. Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist induced desensitization, receptor inactivation, and phorbol ester treatment. J. Pharmacol. Exp. Ther. 30: 200-206, 1986.
23. Harper, J. F., and G. Brooker. Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2′0 acetylation by acetic anhydride in aqueous solution. J. Cyclic Nucleotide Res. 1: 207-218, 1975.
24. Jones, C. A., J. M. Madison, M. Tom-Moy, and J. K. Brown. Muscarinic cholinergic inhibition of adenylate cyclase in airway smooth muscle. Am. J. Physiol. 253 (Cell Physiol. 22): C97-C104, 1987.
25. Lucchessi, P.A., C. R. Scheid, F. D. Romano, M. E. Kargacin, D. Mullikin-Kilpatrick, H. Yamaguchi, and T. W. Honeyman. Ligand binding and G protein coupling of muscarinic receptors in airway smooth muscle. Am J. Physiol. 258 (Cell Physiol. 27): C730-C738, 1990.
26. Madison, J. M. Muscarinic receptor reserve of airway smooth muscle and the response to isoproterenol. J. Appl. Physiol. 68: 1017-1023, 1990.
27. Munson, P. J., and D. Rodbard. LIGAND a versatile computerized approach for characterization of ligand binding systems. Anal. Biochem. 107: 220-239, 1980.
28. Murlas, C., J. A. Nadel, and J. M. Roberts. The muscarinic receptors of airway smooth muscle: their characterization in vitro. J. Appl. Physiol. 52: 1084-1091, 1982.
29. Nathanson, N. M. Binding of agonists and antagonists to muscarinic acetylcholine receptors on intact cultured heart cells, J. Neurochem. 41: 1545-1549, 1983.
30. Nathanson, N. M. Molecular properties of the muscarinic acetylcholine receptor. Annu. Rev. Neurosci. 10: 195-236, 1987.
31. Neer, E. J., and D. E. Clapham. Roles of G protein subunits in transmembrane signalling. Nature Land. 333: 129-134, 1988.
32. Roffel, A. F., H. Meurs, C. R. S. Elzinga, and J. Zaagsma. Characterization of the muecarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle cells. Br. J. Pharmacol. 97: 293-296, 1990.
33. Rothberg, K. G., P. L. Morris, and J. S. Douglas. Characterization of cholinergic muscarinic receptors in cow tracheal muscle membranes. Biochem. Pharmacol. 36: 1687-1695, 1987.
34. Sankary, R. M., C. A. Jones, J. M. Madison, and J. K. Brown. Muscarinic cholinergic inhibition of cyclic AMP accumulation in airway smooth muscle. Am. Rev. Respir. Dis. 138: 145-150, 1988.
35. Schaefer, O. P., M. F. Ethier, and J. M. Madison. Muscarinic regulation of cyclic AMP in bovine trachealis cells Am. J. Respir. Cell Mol. Biol. 13: 217-226, 1995.
36. Shahid, M., R. G. M Van Amsterdam, J. De Boer, R. E. Ten Berge, C. D. Nicholson, and J. Zaagsma. The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br: J. Pharmacol. 104: 471-477, 1991.
37. Steiner, A. L. Cyclic AMP and cyclic GMP. In: Methods of Hormone Radioimmunoassay, edited by B. M. Jaffee and H. R. Behrman. New York: Academic, 1979, p. 3-17.
38. Takayanagi, I., T. Hisayama, Y. Kiuchi, and H. Sudo. Propylbenzylcholine mustard discriminates between two subtypes of muscarinic cholinoceptors in guinea pig taenia caecum. Arch. Int. Pharmacodyn. 298: 210-219, 1989.
39. Widdop, S., K. Daykin, and I. P. Hall. Expression of muscarinic M2 receptors in cultured human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 9: 541-546, 1993
40. Wills, M., and J. S. Douglas. Aging and cholinergic responses in bovine trachealis muscle. Br. J. Pharmacol. 93: 918-924, 1988.
41. Yamaguchi, H. A novel concentric double-barrelled calcium-selective microelectrode for small cells. Can. J. Physiol. Pharmacol. 65: 1006-1008, 1987.
42. Yang, C. M., S.-P. Chou, and T.-C. Sung. Muscarinic receptor subtypes coupled to generation of different second messengers in isolated tracheal smooth muscle cells. Br. J. Pharmacol. 104: 613-618, 1991.
43. 3 muscarinic receptors. Br. J. Pharmacol. 110: 983-989, 1993.
44. Zar, J. H. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice-Hall, 1974.