Delta-9-tetrahydrocannabinol: An inhibitor of STAT1α protein tyrosine phosphorylation

Biochemical Pharmacology

Volumn 51, Issue 7, 1996, Pages 967-973

  Zheng, Zhi Ming ^a,b   Specter, Steven ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

immunosuppression; interferon stimulated gene factor 3; macrophages; signal transduction

Indexed keywords

DRONABINOL; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; PROTEIN; STAT1ALPHA PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0029925712     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02434-4     Document Type: Article

References (45)

1. Darnell JEJr, Kerr IM and Stark GR, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signal proteins. Science 264: 1415-1421, 1994.
2. Taniguchi T, Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268: 251-255, 1995.
3. Hill CS and Treisman R, Transcriptional regulation by extracellular signals: Mechanisms and specificity. Cell 80: 199-211, 1995.
4. Schindler C, Shuai K, Prezioso VR and Darnell JE Jr, Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257: 809-813, 1992.
5. Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell JE Jr and Yancopoulos GD, Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267: 1349-1353, 1995.
6. Shuai K, Schindler C, Prezioso VR and Darnell JE Jr, Activation of transcription by IFN-γ: Tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258: 1808-1812, 1992.
7. Greenlund AC, Farrar MA, Viviano BL and Schreiber RD, Ligand-induced IFNγ receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO J 13: 1591-1600, 1994.
8. David M and Larner AC, Activation of transcription factors by interferon-alpha in a cell-free system. Science 257: 813-815, 1992.
9. Larner AC, David M, Feldman GM, Igarashi K-i, Hackett RH, Webb DSA, Sweitzer SM, Petricoin EF III and Finbloom DS, Tyrosine phosphorylation of DNA binding proteins by multiple cytokines. Science 261: 1730-1733, 1993.
10. Perez C, Wietzerbin J and Benech PD, Two cis-DNA elements involved in myeloid-cell-specific expression and gamma interferon (IFN-γ) activation of the human high-affinity Fcγ receptor gene: A novel IFN regulatory mechanism. Mol Cell Biol 13: 2182-2192, 1993.
11. Fu X-Y, Schindler C, Improta T, Aebersold R and Darnell JE Jr, The proteins of ISGF-3, the interferon α-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci USA 89: 7840-7843, 1992.
12. Shuai K, Stark GR, Kerr IM and Darnell JE Jr, A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 261: 1744-1746, 1993.
13. Nahas GG, Suciu-Foca N, Armand J-P and Morishima A, Inhibition of cellular immunity in marijuana smokers. Science 183: 419-420, 1974.
14. Klein TW, Newton CA, Widen R and Friedman H, The effect of delta-9-tetrahydrocannabinol and 11-hydroxy-delta-9-tetrahydrocannabinol on T-lymphocyte and B-lymphocyte mitogen responses. J Immunopharmacol 7: 451-466, 1985.
15. Specter SC, Klein TW, Newton C, Mondragon M, Widen R and Friedman H, Marijuana effects on immunity: Suppression of human natural killer cell activity by delta-9-tetrahydrocan-nabinol. Int J Immunopharmacol 8: 741-745, 1986.
16. 9-tetrahydrocannabinol. J Leukoc Biol 50: 423-426, 1990.
17. Zheng Z-M, Specter S and Friedman H, Inhibition by delta-9-tetrahydrocannabinol of tumor necrosis factor alpha production by mouse and human macrophages. Int J Immunopharmacol 14: 1445-1452, 1992.
18. Zheng ZM, Specter S and Friedman H, Serum proteins affect the inhibition by delta-9-tetrahydrocannabinol of tumor necrosis factor alpha production by mouse macrophages. Adv Exp Med Biol 335: 89-93, 1993.
19. 9-Tetrahydrocannabinol inhibition of tumor necrosis factor-α: Suppression of post-translation events. J Pharmacol Exp Ther 267: 1558-1565, 1993.
20. Blanchard DK, Newton C, Klein TW, Stewart WE II and Friedman H, In vitro and in vivo suppressive effects of delta-9-tetrahydrocannabinol on interferon production by murine spleen cells. Int J Immunopharmacol 8: 819-824, 1986.
21. Zheng ZM and Specter S, Suppression by delta-9-tetrahydrocannabinol of lipopolysaccharide-induced and intrinsic tyrosine phosphorylation and protein expression in mouse peritoneal macrophages. Biochem Pharmacol 47: 2243-2252, 1994.
22. Zheng ZM, Specter SC and Lancz G, Bovine serum albumin preparations enhance in vitro production of tumor necrosis factor a by murine macrophages. Immunol invest 24: 737-756, 1995.
23. Ruff-Jamison S, Chen K and Cohen S, Induction by EGF and interferon-γ of tyrosine phosphorylated DNA binding proteins in mouse live nuclei. Science 261: 1733-1736, 1993.
24. Weinstein SL, Gold MR and DeFranco AL, Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc Natl Acad Sci USA 88: 4148-4152, 1991.
25. Weinstein SL, Sanghera JS, Lemke K, DeFranco AL and Pelech SL, Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J Biol Chem 267: 14955-14962, 1992.
26. Weinstein SL, June CH and DeFranco AL, Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14. J Immunol 151: 3829-3838, 1993.
27. Dong Z, O'Brian CA and Fidler IJ, Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity. J Leukoc Biol 53: 53-60, 1993.
28. Dong Z, Qi X and Fidler IJ, Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products. J Exp. Med 177: 1071-1077, 1993.
29. Uehara Y and Fukazawa H, Use and selectivity of herbimycin A as inhibitor of protein tyrosine kinases. Methods Enzymol 201: 370-379, 1991.
30. Levitzki A and Gazit A, Tyrosine kinase inhibition: An approach to drug development. Science 267: 1782-1788, 1995.
31. Farrar MA and Schreiber RD, The molecular cell biology of interferon-γ and its receptor. Annu Rev Immunol 11: 571-611, 1993.
32. Igarash K-i, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, Larner AC and Finbloom DS, Interferon-γ induces tyrosine phosphorylation of interferon-γ receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. J Biol Chem 269: 14333-14336, 1994.
33. Manthey CL, Perera P-Y, Salkowski CA and Vogel SN, Taxol provides a second signal for murine macrophage tumoricidal activity. J Immunol 152: 825-831, 1994.
34. Meltzer MS, Macrophage activation for tumor cytotoxicity: Characterization of priming and trigger signals during lymphokine activation. J Immunol 127: 179-183, 1981.
35. Nicolet CM and Paulnock DM, Promoter analysis of an interferon-inducible gene associated with macrophage activation. J Immunol 152: 153-162, 1994.
36. Hayes MP and Zoon KC, Priming of human monocytes for enhanced lipopolysaccharide responses: Expression of alpha interferon, interferon regulatory factors, and tumor necrosis factor. Infect Immun 61: 3222-3227, 1993.
37. Vassalli P, The pathophysiology of tumor necrosis factor. Annu Rev Immunol 10: 411-452, 1992.
38. Yu S-F, Koerner TJ and Adams DO, Gene regulation in macrophage activation: Differential regulation of genes encoding for tumor necrosis factor, interleukin-1, JE, and KC by interferon-γ and lipopolysaccharide. J Leukoc Biol 48: 412-419, 1990.
39. Caswell A, Marijuana as medicine. Med J Aust 156: 497-498, 1992.
40. Block RI and Ghoneim MM, Effects of chronic marijuana use on human cognition. Psychopharmacology 110: 219-228, 1993.
41. Nahas GG and Latour C, The human toxicity of marijuana. Med J Aust 156: 495-497, 1992.
42. Gupta S, Grieco MH and Cushman P Jr, Impairment of rosette-forming T lymphocytes in chronic marijuana smokers. N Engl J Med 291:874-877, 1974.
43. Munro S, Thomas KL and Abu-Shaar M, Molecular characterization of a peripheral receptor for cannabinoids. Nature 365: 61-65, 1993.
44. Lynn AB and Herkenham M, Localization of cannabinoid receptors and nonsaturable high density cannabinoid binding sites in peritoneal tissues of the rat: Implications for receptor-mediated immune modulation by cannabinoids. J Pharmacol Exp Ther 268: 1612-1623, 1994.
45. 9-Tetrahydrocannabinol, cytokines, and immunity to Legionella pneumophila. Proc Soc Exp Biol Med 209: 205-212, 1995.