Relationship between structural and hemodynamic heterogeneity in microvascular networks

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 270, Issue 2 39-2, 1996, Pages

  Pries, A R ^a   Secomb, T W ^b   Gaehtgens, P ^b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b NONE

Author keywords

hematocrit; hemodynamics; network architecture; topology; transit time

Indexed keywords

ARTICLE; BLOOD FLOW; CONDUCTANCE; CONTROLLED STUDY; GEOMETRY; HEMATOCRIT; HEMODYNAMICS; MALE; MESENTERY; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT; SIMULATION; STRUCTURE ANALYSIS; TOPOGRAPHY;

EID: 0029925589     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.270.2.h545     Document Type: Article

References (23)

1. Dawant, B., M. Levin, and A. S. Popel. Effect of dispersion of vessel diameters and lengths in stochastic networks. I. Modeling of microcirculatory flow. Microvasc. Res. 31: 203-222, 1986.
2. Duling, B. R., and D. H. Damon. An examination of the measurement of flow heterogeneity in striated muscle. Circ. Res. 60: 1-13, 1987.
3. Ellsworth, M. L., A. S. Popel, and R. N. Pittman. Assessment and impact of heterogeneities of convective oxygen transport parameters in capillaries of striated muscle: experimental and theoretical. Microvasc. Res. 35: 341-362, 1988.
4. Fenton, B. M., and B. W. Zweifach. Microcirculatory model relating geometrical variation to changes in pressure and flow rate. Ann. Biomed. Eng. 9: 303-321, 1981.
5. Frazer, P. A., L. H. Smaje, and V. Verrinder. Microvascular pressures and filtration coefficients in the cat mesentery. J. Physiol. Lond. 283: 439-456, 1978.
6. Gaehtgens, P., A. R. Pries, and K. Ley. Topological approach to the analysis of microvessel structure and hematocrit distribution. In: Microvascular Networks: Experimental and Theoretical Studies, edited by A. S. Popel and P. C. Johnson. Basel, Switzerland: Karger, 1986, p. 52-60.
7. House, S. D., and H. H. Lipowsky. Microvascular hematocrit and red cell flux in rat cremaster muscle. Am. J. Physiol. 252 (Heart Circ. Physiol. 21): H211-H222, 1987.
8. Levin, M., B. Dawant, and A. S. Popel. Effect of dispersion of vessel diameters and lengths in stochastic networks. II. Modeling of microvascular hematocrit distribution. Microvasc. Res. 31: 223-234, 1986.
9. Ley, K., A. R. Pries, and P. Gaehtgens. Topological structure of rat mesenteric microvessel networks. Microvasc. Res. 32: 315-332, 1986.
10. Lipowsky, H. H., S. Usami, and S. Chien. In vivo measurements of "apparent viscosity" and microvessel hematocrit in the mesentery of the cat. Microvasc. Res. 19: 297-319, 1980.
11. Murray, J. D. Mathematical Biology Berlin: Springer-Verlag, 1993.
12. Potter, R. F., and A. C. Groom. Capillary diameter and geometry in cardiac and skeletal muscle studied by means of corrosion casts. Microvasc. Res. 25: 68-84, 1983.
13. Pries, A. R., A. Fritzsche, K. Ley, and P. Gaehtgens. Redistribution of red blood cell flow in microcirculatory networks by hemodilution. Circ. Res. 70: 1113-1121, 1992.
14. Pries, A. R., and P. Gaehtgens. Dispersion of blood cell flow in microvascular networks. In: Microvascular Mechanics: Hemodynamics of Systemic and Pulmonary Microcirculation, edited by J. S. Lee and T. C. Skalak. New York: Springer-Verlag, 1989, p. 50-64.
15. Pries, A. R., K. Ley, and P. Gaehtgens. Generalization of the Fahraeus principle for microvessel networks. Am. J. Physiol. 251 (Heart Circ. Physiol. 20): H1324-H1332, 1986.
16. Pries, A. R., T. W. Secomb, and P. Gaehtgens. Structure and hemodynamics of microvascular networks: heterogeneity and correlations. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H1713-H1722, 1995.
17. Pries, A. R., T. W. Secomb, P. Gaehtgens, and J. F. Gross. Blood flow in microvascular networks-experiments and simulation. Circ. Res. 67: 826-834, 1990.
18. Pries, A. R., T. W. Secomb, T. Gessner, M. B. Sperandio, J. F. Gross, and P. Gaehtgens. Resistance to blood flow in microvessels in vivo. Circ. Res. 75: 904-915, 1994.
19. Renkin, E. M. Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscle. Am. J. Physiol. 197: 471-491, 1959.
20. Renkin, E. M. Regulation of the microcirculation. Microvasc. Res. 30: 251-263, 1985.
21. Sarelius, I. H. An analysis of microcirculatory flow heterogeneity using measurements of transit time. Microvasc. Res. 40: 88-98, 1990.
22. Zweifach, B. W. Quantitative studies of microcirculatory structure and function. I. Analysis of pressure distribution in the terminal vascular bed in cat mesentery. Circ. Res. 34: 843-857, 1974.
23. Zweifach, B. W., and H. H. Lipowsky. Quantitative studies of microcirculatory structure and function. III. Microvascular hemodynamics of cat mesentery and rabbit omentum. Circ. Res. 41: 380-390, 1977.