Decrease in benzodiazepine receptor binding in a patient with Angelman syndrome detected by iodine-123 iomazenil and single-photon emission tomography

European Journal of Nuclear Medicine

Volumn 23, Issue 5, 1996, Pages 598-604

  Odano, Ikuo ^a   Anezaki, Toshiharu ^b   Ohkubo, Masaki ^a   Yonekura, Yoshiharu ^d   Onishi, Yoshihiro ^c   Inuzuka, Takashi ^b   Takahashi, Makoto ^a   Tsuji, Shuji ^b  

^a NIIGATA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c Biomedical Imaging Research Center   (Japan)

^d Nihon Medi Physics   (Japan)

Author keywords

Angelman syndrome; Benzodiazepine receptor; Cerebral blood flow; GABA(A) receptor; Iodine 123 iomazenil

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; IODINE 123; IOFETAMINE I 123; IOMAZENIL; RECEPTOR SUBUNIT;

ADULT; ARTICLE; BASAL GANGLION; BRAIN BLOOD FLOW; CASE REPORT; CEREBELLUM; CHROMOSOME 15Q; CHROMOSOME PAIRING; CLINICAL FEATURE; DRUG RECEPTOR BINDING; FEMALE; FRONTAL CORTEX; HAPPY PUPPET SYNDROME; HUMAN; NEUROTRANSMISSION; RECEPTOR DENSITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TEMPORAL CORTEX;

EID: 0029925532     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00833400     Document Type: Article

References (28)

1. Angelman H. 'Puppet' children. A report on three cases. Dev Med Child Neurol 1965; 7: 681-688.
2. Williams CA, Gray BA, Hendrickson JE, Stone JW, Cantu ES. Incidence of 15q deletions in the Angelman syndrome: a survey of twelve affected persons. Am J Med Genet 1989; 32: 339-345.
3. Beuten J, Mangelschots K, Buntinx I, Coucke P, Brouwer OF, Hennekam RCM, van Broeckhoven C, Willems PJ. Molecular study of chromosome 15 in 22 patients with Angelman syndrome. Hum Genet 1993; 90: 489-495.
4. A receptor β3 subunit to the Angelman/Prader-Willi region of human chromosome 15. Am J Hum Genet 1991; 49: 330-337.
5. A receptor β3-subunit gene. Lancet 1992; 339: 366-367.
6. Olsen RW. The GABA postsynaptic membrane receptor-ionophore complex. Mol Cell Biochem 1981; 39: 261-279.
7. Beer HF, Blauenstein PA, Hasler PH, Delaloye B, Riccabona G. Bangerl I, Hunkeler W, Bonetti EP, Pieri L, Richards G, Schubiger PA. In vivo and in vitro evaluation of iodine-123-Ro 16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors. J Nucl Med 1990; 31: 1007-1014.
8. 123I]iomazenil in healthy human subjects. Psychiatry Res Neuroimaging 1992; 45: 67-77.
9. 18FDG-PET and ictal EEG findings in patients with medically intractable complex partial seizures. Acta Neurochir Suppl (Wien) 1990; 50: 95-99.
10. Bartenstein P, Ludolph A, Schober O, Lottes G, Scheidhauer K, Sciuk J, Beer H-F. Benzodiazepine receptors and cerebral blood flow in partial epilepsy. Eur J Nucl Med 1991; 18: 111-118.
11. Johnson EW, de Lanerolle NC, Kim JH, Sundaresan S, Spencer DD, Mattson RH, Zoghbi SS, Baldwin RM, Hoffer PB, Seibyl JP, Innis RB. "Central" and "peripheral" benzodiazepine receptors: opposite changes in human epileptogenic tissue. Neurology 1992; 42: 811-815.
12. Yonekura Y, Onishi Y, Mukai T, Nishizawa S, Tanaka F, Okazawa H, Ishizu K, Fujita T, Tamaki N, Shibasaki H, Konishi J. Simple quantification of benzodiazepine receptor binding with I-123 iomazenil SPECT using standard arterial input function and table look-up method. J Nucl Med 1994; 35 (Suppl): 194.
13. Onishi Y, Yonekura Y, Mukai T, Nishizawa S, Tanaka F, Okazawa H, Ishizu K, Fujita T, Shibasaki H, Konishi J. Simple quantification of benzodiazepine receptor binding and ligand transport using iodine-123-iomazenil and two SPECT scans. J Nucl Med 1995; 36: 1201-1210.
14. Onishi Y, Yonekura Y, Nishizawa S, Tanaka F, Okazaki H, Ishizu K, Fujita T, Konishi J, Mukai T. Noninvasive quantification of iodine-123-iomazenil SPECT. J Nucl Med 1996; 37: 374-378.
15. 125I labeled iodobenzodiazepines. Appl Radiat Isot 1991; 42: 173-175.
16. 11C]flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography. J Cereb Blood Flow Metab 1991; 11: 735-744.
17. Abi-Dargham A, Laruelle M, Seibyl J, Rattner Z, Baldwin RM, Zoghbi SS, Zeu-Ponce Y, Bremner JD, Hyde TM, Charney DS, Hoffer PB, Innis RB. SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms. J Nucl Med 1994; 35: 228-238.
18. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welche ML. A quantitative method for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 1984; 15: 217-227.
19. 123I]iodoamphetamine (IMP) tomography. J Nucl Med 1982; 23: 196-203.
20. 123I]-iodoamphetamine SPECT. Nucl Med Commun 1994; 15: 560-564.
21. A receptors. FASEB J 1990; 4: 1469-1480.
22. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci 1992; 12: 4151-4172.
23. Knoll JHM, Cheng SD, Lalande M. Allele specificity of DNA replication timing in the Angelman/Prader-Willi syndrome imprinted chromosomal region. Nature Genet 1994; 6: 41-46.
24. Nicholls RD, Gottlieb W, Russell LB, Davda M. Horsthemke B, Rinchik EM. Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse. Proc Natl Acad Sci USA 1993; 90: 2050-2054.
25. Knoll JHM, Sinnett D, Wagstaff J, Glatt K, Wilcox AS, Whiting PM, Wingrove P, Sikela JM, Lalande M. FISH ordering of reference markers and of the gene for the α5 subunit of the γ-aminobutyric acid receptor (GABA5) within the Angelman and Prader-Willi syndrome chromosomal regions. Hum Mol Genet 1993; 2: 183-189.
26. Cattanach BM, Barr JA, Evans KP, Burtenshaw M, Beechey CV, Left SE, Brannan CI, Copeland NG, Jenkins NA, Jones J. A candidate mouse model for Prader-Willi syndrome which shows an absence of Snrpn expression. Nature Genet 1992; 2: 270-274.
27. Jay V, Becker LE, Chan F-W, Perry TL. Puppet-like syndrome of Angelman: a pathologic and neurochemical study. Neurology 1991; 42: 416-422.
28. Enna SJ, Karbon EW. GABA receptors: an overview. In: Olsen RW, Venter JC, eds. Benzodiazepine/GABA receptors and chloride channels: structural and functional properties. New York: Alan R. Liss, 1986: 41-56.