The antiinfluenza activity of pyrrolo[2,3-d]pyrimidines

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 5, 1996, Pages 565-568

  Sznaidman, Marcos L ^a   Meade, Eric A ^a   Beauchamp, Lilia M ^a   Russell, Stuart ^b   Tisdale, Margaret ^b  

^a Burroughs Wellcome Co   (United States)

^b WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; ANTIVIRUS AGENT; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG SYNTHESIS; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFLUENZA; INFLUENZA VIRUS A; INFLUENZA VIRUS B; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION;

EID: 0029925337     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00070-4     Document Type: Article

References (7)

1. 1H-NMR and mass spectra. Melting points are: 5: 192-196 °C, 7: 218-221 °C, 9: 193-195 °C, 11: 160-162 °C, 13: 170-173 °C, 15: 180-182 °C.
2. West, R. A.; Beauchamp, L. J. Org. Chem. 1961, 26, 3809.
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4. Tisdale, M.; Appleyard, G.; Tuttle, J. V.; Nelson, D. J.; Nusinoff-Lehrmann, S.; Al Nakib, W.; Stables, J. N.; Purifoy, D. J. M.; Powell, K. L.; Darby, G. Antiviral Chem. Chemoter. 1993, 4, 281.
5. Davies, W. L.; Grunert, R. R.; Haff, R. F.; McGahen, J. W.; Neumayer, E. M.; Paulshock, M.; Watts, J. C.; Wood, T. R.; Hermann, E. C.; Hoffmann, C. E. Science 1964, 144, 862.
6. Compound 9 was administered by oral gavage to a group of 5 male 20 g Balb/c mice in three doses of 50 mg/Kg. Animals were dosed 4 h before aerosol challenge with A/Sweden/50 and 4 and 20 h after challenge. A positive control group were given 50 mg/Kg of Amantadine, and a negative control group were untreated. All animals were killed at 24 h and the lunge removed for virus titration. Compound 9 had no antiviral effect.
7. Mazel, P. Fundamentals of Drug Metabolism and Drug Disposition; LaDu, B. N.; Mandel, G. H.; Leong Way, E., Eds.; The Williams and Wilkins Co.: Baltimore, 1971; pp 527-545.