Recovery from NMDA-induced intracellular acidification is delayed and dependent on extracellular bicarbonate

American Journal of Physiology - Cell Physiology

Volumn 270, Issue 2 39-2, 1996, Pages

  Canzoniero, L M T ^a   Sensi, S L ^a   Choi, D W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2',7' bis(carboxyethyl) 5(6) carboxyfluorescein; acidity; cortex; cortical neurons; glutamate; N methyl D aspartate; pH

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 2,7 BIS(CARBOXYETHYL) 6 CARBOXYFLUORESCEIN; 4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 (N ETHYL N ISOPROPYL)AMILORIDE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ACIDIFICATION; ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL PH; DOSE RESPONSE; EMBRYO; ION EXCHANGE; MOUSE; NERVE CELL CULTURE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL;

EID: 0029925292     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.270.2.c593     Document Type: Article

References (43)

1. 2. J. Biol. Chem. 264: 10008-10014, 1989.
2. Ahmed, Z., and J. A. Connor. Intracellular pH changes induced by calcium influx during electrical activity in molluscan neurons. J. Gen. Physiol. 75: 403-426, 1980.
3. Aickin, C. C. Intracellular pH regulation by vertebrate muscle. Annu. Rev. Physiol. 48: 349-361, 1986.
4. Aronson, P. S., and S. E. Bounds. Harmaline inhibition of Na-dependent transport in renal microvillus membrane vesicles. Am. J. Physiol. 238 (Renal Fluid Electrolyte Physiol 7): F210-F217, 1980.
5. Beaty, D. M., B. M. Chronwall, D. E Howard, T. B. Wiegmann and S. J. Morris. Calcium regulation of intracellular pH in pituitary intermediate lobe melatropes. Endocrinology 133: 972-984, 1993.
6. 3, and metabolic inhibitors. J. Gen. Physiol. 67: 91-112, 1976.
7. Boron, W. F., and J. M. Russel. Stoichiometry and ion dependencies of the intracellular pH regulation mechanism in squid giant axons. J. Gen. Physiol. 81: 373-399, 1983.
8. Busa, W. B. Mechanisms and consequences of pH-mediated cell regulation. Annu. Rev. Physiol. 48: 389-402, 1986.
9. Cabantchick, Z. I., P. A. Knauf, and A. Rothstein. The anion transport system of the red blood cell. The role of membrane protein evaluated by the use of probes. Biochim. Biophys. Acta 515: 239-302, 1978.
10. Carafoli, E. Intracellular calcium homeostasis. Annu. Rev. Biochem. 56: 395-433, 1987.
11. Chesler, M. The regulation and modulation of pH in nervous system. Prog. Neurobiol. Oxf. 34: 401-427, 1990.
12. Choi, D. W. Calcium mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11: 465-469, 1988.
13. Deitmer, J. W., and T. Munsch. Kainate/glutamate induced changes in intracellular calcium and pH in leech glial cells. Neuroreport 3: 693-696, 1992.
14. Dixon, D. B., K. I. Takahashi, and D. R. Copenhagen. L-Glutamate suppress HVA calcium current in catfish horizontal cells by raising proton concentration. Neuron 11: 267-277, 1993.
15. Endres, W., K. Ballanyi, G. Serve, and P. Grafe. Excitatory amino acids and intracellular pH in motoneurons of isolated frog spinal cord. Neurosci. Lett. 72: 54-58, 1986.
16. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J. Neurosci. 13: 1993-2000, 1993.
17. Hartley, Z., and J. M. Dubinsky. Changes in intracellular pH associated with glutamate excitotoxicity. J. Neurosci. 13: 4690-4699, 1993.
18. Irwin, R. P., S. Lin, R. T. Long, and S. M. Paid. N-methyl-D aspartate induces a rapid, reversible, and calcium-dependent intracellular acidosis in cultured fetal rat hippocampal neurons. J. Neurosci. 14: 1352-1357, 1994.
19. Kaku, D. A., R. G. Giffard, and D. W. Choi. Neuroprotective effects of glutamate antagonists and extracellular acidity. Science Wash. DC 260: 1516-1518, 1993.
20. Kraig, R. P., W. A. Pulsinelli, and F. Plum. Heterogeneous distribution of hydrogen and bicarboante ions during complete brain ischemia. Prog. Brain Res. 63: 155-166, 1985.
21. Lazdunski, M., C. Frelin, and P. Vigne. The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J. Mol. Cell. Cardiol. 17: 1029-1042, 1985.
22. MacDermott, A. B., M. Mayer, G. L. Westbrook, S. J. Smith, and J. L. Barker. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature Lond. 321: 519-522, 1986.
23. Meech, R. W., and R. C. Thomas. The effect of calcium injection on the intracellular sodium and pH of snail neurons. J. Physiol. Lond. 265: 867-879, 1977.
24. + on the electrical properties of excitable cells. Ann. Rev. Neurosci. 7: 257-278, 1984.
25. Nachsen, D. A., and P. Drapeau. The regulation of cytosolic pH in isolated presynaptic nerve terminals from rat brain. J. Gen. Physiol. 91: 289-303, 1988.
26. Newman, E. A. Sodium-bicarbonate cotransport in retinal Müller (glial) cells of the salamander. J. Neurosci. 11: 3972-3983, 1991.
27. Nichols, D. G. A role for the mitochondrion in the protection against calcium overload? Prog. Brain Res. 63: 97-106, 1985.
28. Ou-yang, Y., P. Mellergård, and B. K Siesjö. Regulation of intracellular pH in single rat cortical neurons in vitro: a microspectrofluorimetric study. J. Cereb. Blood Flow Metab. 13: 827-840, 1993.
29. Pocock, G., and C. D. Richards. Hydrogen ion regulation in rat cerebellar granule cells studied by single-cell fluorescence microscopy. Eur. J. Neurosci. 4: 136-143, 1992.
30. + exchanger. J. Biol. Chem. 266: 2739-2745, 1991.
31. 2- in lymphocytes. J. Cell Biol. 95: 189-196, 1982.
32. Roos, A., and W. F. Boron. Intracellular pH. Physiol. Rev. 61: 296-434, 1981.
33. Rose, K., M. P. Goldberg, and D. W. Choi. Cytotoxicity in murine neocortical cell culture. In : In Vitro Biological Systems, Methods in Toxicology, edited by C. A. Tyson and J. M. Frazier. San Diego, CA: Academic Press, 1992, p. 46-60.
34. Rothman, S. M. The neurotoxicity of excitatory amino acids is produced by passive chloride influx. J. Neurosci. 5: 1483-1489, 1985.
35. 3 exchange. J. Physiol. Lond. 475: 59-67, 1994.
36. 2+ dependent reduction in intracellular pH in cortical neurons; recovery depends on extracellular bicarbonate (Abstract). Soc. Neurosci. 19: 196.1, 466, 1993.
37. Siesjo, B. K., C. D. Aghard, and F. Bengtsson. Free radicals and brain damage. Cereb. Brain Metab. Rev. 1: 165-211, 1989.
38. +. Proc. Natl. Acad. Sci. USA 87: 6445-6449, 1990.
39. Thomas, J. A., R. N. Buchsbaum., A. Zimniak, and E. Racker. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 18: 2210-2218, 1979.
40. Thomas, R. C. The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurons. J. Physiol. Lond. 273: 317-338, 1977.
41. Trivedi, B., and W. Danforth. Effect of pH on the kinetics of frog muscle phosphofructokinase. J. Biol. Chem. 241: 4110-4114, 1966.
42. Ui, M. A role of phosphofructokinase in pH-dependent regulation of glycolisis. Biochim. Biophys. Acta 124: 310-322, 1966.
43. Waxman, L. Calcium-activated proteases in mammalian tissues. Meth. Enzymol. 80: 664-680, 1981.