Identification and functional analysis of Ly-6A/E as a thymic and bone marrow stromal antigen

Journal of Immunology

Volumn 156, Issue 7, 1996, Pages 2391-2399

  Izon, David J ^a   Oritani, Kenji ^c   Hamel, Maaike ^a   Calvo, Concepcion Revilla ^a   Boyd, Richard L ^b   Kincade, Paul W ^c   Kruisbeek, Ada M ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGEN ANTIBODY REACTION; ANTIGEN RECOGNITION; ARTICLE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STROMA CELL; T LYMPHOCYTE; THYMUS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, LY; BONE MARROW; BONE MARROW CELLS; CELL LINE; CLONING, MOLECULAR; CROSS-LINKING REAGENTS; DNA, COMPLEMENTARY; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; THYMUS GLAND;

EID: 0029925156     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (82)

1. Ritter, M. A., and R. L. Boyd. 1993. Development in the thymus: it takes two to tango. Immunol. Today 14:462.
2. Van Ewijk, W., E. W. Shores, and A. Singer. 1994. Crosstalk in the mouse thymus. Immunol. Today 15:214.
3. Zlotnik, A., and T. A. Moore. 1995. Cytokine production and requirements during T-cell development. Curr. Opin. Immunol. 7:206.
4. Peschon, J. L., P. J. Momssey, K. H. Grabstein, F. J. Ramsdell, E. Maraskovsky, B. C. Gliniak, L. S. Park, S. F. Ziegler, D. E. Williams, C. B. Ware, J. D. Meyer, and B. L. Davison. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 280:1955.
5. Von Freeden-Jeffry, U., P. Vieira, L. A. Lucine, T. McNeil, S. E. G., Burbach, and R. Murray. 1995. Lymphopenia in interleukin-7 gene deleted mice identified interleukin-7 as a nonredundant cytokine. J. Exp. Med. 181:1519.
6. DiSanto, J. P., W. Müller, D. Guy-Grand, A. Fischer, and K. Rajewski. 1995. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor y chain. Proc. Natl. Acad. Sci. USA 92:377.
7. + B cells and produces a novel growth factor affecting B and T Lineage cells. Exp. Hematol. 22:321.
8. Singer, K. H., S. M. Denning, L. P. Whichard, and B. F. Haynes. 1990. Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells. J. Immunol. 144:2931.
9. Fine, J. S., and A. M. Kruisbeek. 1991. The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development J. Immunol. 147:2852.
10. Haynes, B. F., and C. S. Heinly. 1995. Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment. J. Exp. Med. 181:1445.
11. Bowen, M. A., D. D. Patel, X. Li, B. Modrell, A. R. Malacko, W.-C. Wang, H. Marquardt, M. Neubauer, J. M. Pesando, U. Fancke, B. F. Haynes, and A. Aruffo. 1995. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J. Exp. Med. 181:2213.
12. + subset in anti-Ia-treated neonatal mice correlates with absence of thymic Ia bearing APC function. J. Exp. Med. 161: 1029.
13. + cytotoxic T cells requires interactions with class I MHC determinants. Nature 333:180.
14. + T cells in major histocompatibility complex class II-deficient mice. Science 253:1417.
15. Cosgrove, D., D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, and D. Mathis. 1991. Mice lacking MHC class II molecules. Cell 66:1051.
16. + T cells. Cell 71:1205.
17. + cytolytic T cells. Nature 344:742.
18. Zúniga-Pflücker, J. C., S. A. McCarthy, M. Weston, D. L. Longo, A. Singer, and A. M. Kruisbeek, 1989. Role of CD4 in thymocyte selection and maturation. J. Exp. Med. 169:2085.
19. + T cells. J. Exp. Med. 171:427.
20. Fung-Leung, W. P., V. A. Wallace, D. Gray, W. C. Sha, H. Pircher, H.-S. Teh, D. Y. Loh, and T. W. Mak. 1993. CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny. Eur. J. Immunol. 23:212.
21. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353:180.
22. Carlow, D. A., N. S. C. van Oers, S. J. Teh, and H. S. Teh. 1992. Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions. J. Immunol. 148:1595.
23. + thymocytes. J. Immunol. 151: 1868.
24. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179:709.
25. Foy, T. M., D. M. Page, T. J. Waldschmidt, A. Schoneveld, J. D. Laman, S. R. Masters, L. Tygrett, J. A. Ledbetter, A. Aruffo, E. Claassen, J. C. Xu, R. A. Flavell, S. Ohen, S. M. Hedrick, and R. J. Noelle. 1995. An essential role for gp39, the ligand for CD40, in thymic selection. J. Exp. Med. 182:1377.
26. Poussier, P., and M. Julius. 1994. Intestinal intraepithelial lymphocytes: the plot thickens. J. Exp. Med. 180:1185.
27. Rocha, B., D. Guy-Grand, and P. Vassalli. 1995. Extrathymic T cell differentiation. Curr. Opin. Immunol. 7:235.
28. Boyd, R. L., C. L. Tucek, D. I. Godfrey, D. J. Izon, T. J. Wilson, N. J. Davidson, A. G. D. Bean, H. M. Ladyman, M. A. Ritter, and P. Hugo. 1993. The thymic microenvironment. Immunol. Today 14:445.
29. Godfrey, D. I., D. J. Izon, T. J. Wilson, C. L. Tucek, and R. L. Boyd. 1988. Thymic stromal elements defined by mAb: ontogeny and modulation in vivo by immunosuppression. Adv. Exp. Med. Biol. 237:269.
30. Izon, D. J., D. I. Godfrey, J. D. Nieland, R. L. Boyd, and A. M. Kruisbeek. 1994. Flow cytometric analysis of thymic stromal cells reveals unexpected shared antigens between histologically defined populations of mymic stromal cells. Int. Immunol. 6:31.
31. Izon, D. J., L. A. Jones, E. E. Eynon, and A. M. Kruisbeek. 1994. A molecule expressed on accessory cells, activated T cells and thymic epithelium is a marker and promoter of T cell activation. J. Immunol. 153:2939.
32. Rock, K. L., H. Rieser, A. Bamezai, J. McGrew, and B. Benacerraf. 1989. The Ly-6 locus: a multigene family encoding phosphatidylinositol-anchored membrane proteins concerned with T cell activation. Immunol. Rev. 111:195.
33. Shevach, E. M., and P. E. Korty. 1989. Ly-6: a multigene family in search of function. Immunol. Today 10:195.
34. LeClair, K. P., R. G. E. Palfree, P. M. Flood, U. Hämmerling, and A. L. M. Bothwell. 1986. Isolation of a murine Ly-6 cDNA reveals a new multigene family. EMBO J. 5:3227.
35. LeClair, K. P., M. Rabin, M. N. Nesbitt, D. Pravtcheva, F. H. Ruddle, R. G. E. Palfree, and A. L. M. Bothwell. 1987. Murine Ly-6 multigene family is located on chromosome 15. Proc. Natl. Acad. Sci. USA 84:1638.
36. Yeh, E. T. H., H. Reiser, B. Benacerraf, and K. L. Rock. 1986. The expression, function and ontogeny of a novel T cell-activating protein, TAP, in the thymus. J. Immunol. 137:1232.
37. Spangrude, G. J., S. Heimfeld, and I. L. Weissman. 1988. Isolation and characterization of the mouse hematopoietic stem cell. Science 241:58.
38. Spangrude, G. J., Y. Aihara, I. L. Weissman, and J. Klein. 1988. The stem cell antigens Sca-1 and Sca-2 subdivide thymic peripheral T lymphocytes into unique subsets. J. Immunol. 141:3697.
39. Bamezai, A., D. Palliser, A. Berezovskaya, J. McGrew, K. Higgins, E. Lacy, and K. L. Rock. 1995. Regulation expression of Ly-6A.2 is important for T cell development. J. Immunol. 154:4233.
40. Pietrangeli, C. E., S. Hayashi, and P. W. Kincade. 1988. Stromal cell lines which support lymphocyte growth: characterization, sensitivity to radiation and responsiveness to growth factors. Eur. J. Immunol. 18:863.
41. Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
42. Kasho, T., J. Ishikawa, K. Oritani, J. Inazawa, H. Tomizawa, O. Muraoka, T. Ochi, and T. Hirano. 1994. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proc. Natl. Acad. Sci. USA 18:863.
43. Van De Rijn, M., S. Heimfeld, G. J. Spangrude, and I. L. Weissman. 1989. Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. Proc. Natl. Acad. Sci. USA 86:4634.
44. Malek, T. R., G. Onega, C. Ghan, R. A. Kroczek, and E. M. Shevach. 1986. Role of Ly-6 in lymphocyte activation. IL Induction of T cell activation by monoclonal anti-Ly-6 antibodies. J. Exp. Med. 164:709.
45. Heath, A. W., W. W. Wu, and M. C. Howard. 1994. Monoclonal antibodies to murine CD40 define two distinct epitopes. Eur. J. Immunol. 24:1828.
46. Hapel, A. J., H. S. Warren, and D. A. Hume. 1984. Different colony-stimulating factors are detected by the "interleukin-3" dependent cell lines FDC-P1 and 32D cl-23. Blood 64:786.
47. Glimcher, L., A. M. Kruisbeek, W. E. Paul, and I. Green. 1983. L Functional activity of a transformed thymic epithelial cell line. Scand. J. Immunol. 17:1.
48. Beardsly, T. R., M. Pierschbacher, G. D. Wetzel, and E. F. Hays. 1983. Induction of T-cell maturation by a cloned line of thymic epithelium (TEPI). Proc. Natl. Acad. Sci. USA 80:6005.
49. + thymocytes in vitro. J. Immunol. 145:4012.
50. Hueber, A.-O., M. Pierres, and H.-T. He. 1992. Sulfated glycans directly interact with mouse Thy-1 and negatively regulate Thy-1 mediated adhesion of thymocytes to thymic epithelial cells. J. Immunol. 148:3692.
51. Hiai, H., Y. Nish, H. Kaneshima, Y. O. Buma, and Y. Nishizuka. 1985. Thymic lymphoid-stromal cell complexes in mice: in vitro assay and mechanism of the complex formation. Exp. Hematol. 13:215.
52. Tucek, C. L., D. L Godfrey, and R. L. Boyd. 1992. Five novel antigens illustrate shared phenotype between mouse thymic stromal cells, thymocytes, and peripheral lymphocytes. Int. Immunol. 4:1021.
53. Cumano, A., K. Dorshkind, S. Gillis, and C. J. Paige. 1990. The influence of S17 stromal cells and interleukin 7 on B cell development. Eur. J. Immunol. 20:2183.
54. Brown, D. 1993. The tyrosine kinase connection: how GPI-anchored proteins activate T cells. Curr. Opin. Immunol. 5:349.
55. Gimble, J. M., K. Medina, J. Hudson, M. Robinson, and P. W. Kincade. 1993. Modulation of lymphohematopoiesis in long-term cultures by gamma-interferon: direct and indirect action on lymphoid and stromal cells. Exp. Hematol. 21:224.
56. LeClair, K. P., M. M. Bridgett, F. J. Dumont, R. G. E. Palfree, U. Hämmerling, and A. L. M. Bothwell. 1989. Kinetic analysts of Ly-6 gene induction in a T lymphoma by interferons and interleukin 1, and demonstration of Ly-6 inducibility in diverse cell types. Bur. J. Immunol. 19:1233.
57. Su, B., and A. L. M. Bothwell. 1989. Biosynthesis of a phosphatidylinositol-glycan-linked membrane protein: signals for posttranslational processing of the Ly-6E antigen. Mol. Cell. Biol. 9:3369.
58. Su, B., G. L. Waneck, R. A. Flavell, and A. L. M. Bothwell. 1991. The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E-mediated T cell activation. J. Cell Biol. 112:377.
59. Stefanová, I., V. Horejsí, I. J. Ansotegui, W. Knapp, and H. Stockinger. 1991. GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science 254:1016.
60. Brown, D. 1993. The tyrosine kinase connection: how GPI-anchored proteins activate T cells. Curr. Opin. Immunol. 5:349.
61. Dumont, F. J., R. Dijkmans, R. G. E. Palfree, R. D. Bote, and L. Coker. 1987. Selective up-regulation by interferon-γ of surface molecules of the Ly-6 complex in resting T cells: the Ly-6A/E and TAP antigens are preferentially enhanced. Eur. J. Immunol. 17:1183.
62. Bamezai, A., H. Reiser, and K. L. Rock. 1988. T cell receptor/CD3 negative variants are unresponsive to stimulation through the Ly-6 encoded molecule, TAP. J. Immunol. 141:1423.
63. Sussman, J. J., T. Saito, E. M. Shevach, R. N. Germain, and J. D. Ashwell. 1988. Thy-1- and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex. J. Immunol. 140:2520.
64. Galy, A. H. M., and H. Spits. 1992. CD40 is functionally expressed on human thymic epithelial cells. J. Immunol. 149:775.
65. MacNeil, I., J. Kennedy, D. I. Godfrey, N. A. Jenkins, M. Masciantonio, C. Mineo, D. J. Gilbert, N. G. Copeland, R. L. Boyd, and A. Zlotnik. 1993. Isolation of a cDNA encoding thymic shared antigen-1. J. Immunol. 151:6913.
66. Melchers, F., and K. Shortman. 1995. Lymphocyte development. Curr. Opin. Immunol. 7:173.
67. Kincade, P. W. 1994. B lymphopoiesis: global factors, local control. Proc. Natl. Acad. Sci. USA 91:2888.
68. Classon, B. I., and L. Coverdale. 1994. Mouse stem cell antigen Sca-2 is a member of the Ly-6 family of cell surface proteins. Proc. Natl. Acad. Sci. USA 91:5296.
69. Fleming, T. J., M. L. Fleming, and T. R. Malek. 1993. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J. Immunol. 151:2399.
70. Montecino-Rodriguez, E., K. S. Landreth, and K. Dorshkind. 1994. Differential expression of bone marrow stromal cell-surface antigens on myeloid and lymphoid cells. Hybridoma 13:175.
71. Sudo, T., M. Ito, Y. Ogawa, M. lizuka, H. Kodama, T. Kunisada, S.-I. Hayashi, M. Ogawa, K. Sakai, S. Nishikawa, and S.-I. Nishikawa. 1989. Interleukin 7 production and function in stromal cell-dependent B cell development. J. Exp. Med. 170:333.
72. Jarvis, L. J., and T. W. LeBien. 1993. Stimulation of human bone marrow stromal cell tyrosine kinases and IL-6 production by contact with B lymphocytes. J. Immunol. 155:2359.
73. Miyake, K., K. Medina, K. Ishihara, M. Kimoto, R. Auerbach, and P. W. Kincade. 1991. A VCAM-like adhesion molecule on marine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. J. Cell. Biol. 114:557.
74. Bamezai, A., and Rock, K. L. 1995. Overexpressed Ly-6A.2 mediates cell-cell adhesion by binding a ligand expressed on thymocytes. Proc. Natl. Acad. Sci. USA. 92:4294.
75. Johnson, R., D. W. Lancki, and F. W. Fitch. 1993. Accessory molecules involved in antigen-mediated cytolysis and lymphokine production by cytotoxic T lymphocyte subsets. 1. Identification of functions for the T cell surface molecules Ly-6C and Thy-1. J. Immunol. 151:2986.
76. Wegener, A.-M. K., F. Letoumeur, A. Hoeveler, T. Brocker, F. Lutom, and B. Malissen. 1992. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68:83.
77. Codias, E. K., T. J. Fleming, C. M. Zacharchuk, J. D. Ashwell, and T. R. Malek. 1992. Role of Ly-6A/E and T cell receptor-ζ for IL-2 production: phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a ζ-independent pathway. J. Immunol. 149:2825.
78. Surh, C. D., and I. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
79. Lee, M. Y., K. L. Fevold, K. Dorshkmd, R. Fukunaga, S. Nagata, and C. Rosse. 1993. In vivo and in vitro suppression of primary B lymphocytopoiesis by tumor-derived and recombinant granulocyte colony-stimulating factor. Blood 82:2062.
80. Dorshkind, K. 1991. In vivo administration of recombinant granulocyte-macrophage colony-stimulating factor results in a reversible inhibition of primary B lymphopoiesis. J. Immunol. 146:4204.
81. Engelhard, D., K. S. Landreth, N. Kapoor, P. W. Kincade, L. E. DeBault, A. Theodore, and R. A. Good. 1983. Cycling of peripheral blood and marrow lymphocytes in cyclic neutropenia. Proc. Natl. Acad. Sci. USA 80:5734.
82. Ogawa, M., Y. Matsuzaki, S. Nishikawa, S. Hayashi, T. Kunisada, T. Sudo, T. Kina, H. Nakaucbi, and S. Nishikawa. 1991. Expression and function of c-kit in hemopoietic progenitor cells. J. Exp. Med. 174:63.