Profound increase of Helicobacter pylori urease activity in gastric antral mucosa at low pH

Digestive Diseases and Sciences

Volumn 41, Issue 5, 1996, Pages 944-949

  Miederer, Siegfried E ^a,b   Grübel, Peter ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Evangelisches Johannes Krankenhaus   (Germany)

Author keywords

ammonia; gastric mucosal barrier; Helicobacter pylori; urease

Indexed keywords

AMMONIA; UREASE;

ARTICLE; CLINICAL ARTICLE; ENZYME ACTIVITY; GASTRITIS; HUMAN; HUMAN TISSUE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STOMACH MUCOSA; STOMACH MUCOSA LESION; STOMACH PH;

EID: 0029924548     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02091535     Document Type: Article

References (35)

1. Goodwin CS, Armstrong JA, Marshall BJ: Campylobacter pyloridis, gastritis, and peptic ulceration. J Clin Pathol 39:353-365, 1986
2. Rauws EAJ, Langenberg W, Houthoff HJ, Zanen HC, Tytgat GNJ: Campylobacter pyloridis-associated chronic active antral gastritis. Gastroenterology 94:33-40, 1988
3. Megraud F: Epidemiology of Helicobacter pylori infection. Gastroenterol Clin North Am 22:(1)73-88, 1993
4. Hessey SJ, Spencer J, Wyatt JI, Sobala G, Rathbone BJ, Axon AT, Dixon MF: Bacterial adhesion and disease activity in Helicobacter-associated chronic gastritis. Gut 31:134-138, 1990
5. Allen A, Flemström G, Garner A, Kivilaakso E: Gastroduodenal mucosal protection. Physiol Rev 73:(4)823-857, 1993
6. Dunn BE, Roop II RM, Sung CC, Sharma SA, Perez-Perez GI, Blaser MJ: Identification and purification of a cpn60 heat shock protein homolog from Helicobacter pylori. Infect Immun 60:1946-1951, 1992
7. Eaton KA, Morgan DR, Krakowka S: Motility as a factor in the colonization of gnotobiotic piglets by Helicobacter pylori. J Med Microbiol 37:123-127, 1992
8. Fauchere JL, Blaser MJ: Adherence of Helicobacter pylori cells and its surface components to HeLa cell membranes. Microb Pathogen 9:1-13, 1990
9. Ferrero RL, Lee A: The importance of urease in acid protection for the gastric-colonizing bacteria Helicobacter pylori and H. felis sp. nov. Microb Ecol Health Dis 4:121-134, 1991
10. Leunk RD: Production of a cytotoxin by Helicobacter pylori. Rev Infect Dis 13(suppl 8):686-689, 1991
11. Marshall BJ, Barrett LJ, Prakash C, McCallum RW, Guerrant RL: Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid. Gastroenterology 99:697-702, 1990
12. Sidebotham RL, Batten JJ, Karim QN, Spencer J, Baron JH: Breakdown of gastric mucus in presence of Helicobacter pylori. J Clin Pathol 44:52-57, 1991
13. Hu LT, Mobley HLT: Purification and N-terminal analysis of urease from Helicobacter pylori. Infect Immun 58:992-998, 1990
14. Perez-Perez GI, Olivares AZ, Cover TL, Blaser MJ: Characteristics of Helicobacter pylori variants selected for urease deficiency. Infect Immun 60:3658-3663, 1992
15. Eaton KA, Brooks CL, Morgan DR, Krakowka S: Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun 59:2470-2475, 1991
16. McColm AA, Bagshaw J, O'Malley C, McClaren A: Is urease a lethal target for therapy of Helicobacter pylori? Microb Ecol Health Dis 4(S):S145, 1991
17. Smoot DT, Mobley HLT, Chippendale JF, Lewison JF, Resau JH: Helicobacter pylori urease is toxic to human gatstric epithelial cells. Infect Immun 58:1992-1994, 1990
18. Hazell SL, Opekun AR, Graham DY: Survival of Campylobacter pylori in acidic environments is independent of urease activity. Gastroenterology 96:A201, 1989
19. Goldie J, Jalali S, Hunt RH, Richardson-McMaster MR: Study of media and pH requirements for the growth of Campylobacter pylori. Gastroenterology 94:(5)A150, 1988
20. Rathbone BJ, West AP, Wyatt JI, Johnson AW, Tompkins DS, Heatley RV: Campylobacter pyloridis, urease, and gastric ulcers. Lancet 12:400-401, 1986
21. DaFonseca-Wollheim F: Die direkte Plasmaammoniak-Bestimmung ohne Enteiweissung. Klin Chem Klin Biochem 11:426, 1973
22. Loffeld RL, Stobberingh E, Arends JW: A review of diagnostic techniques for Helicobacter pylori infection. Dig Dis Sci 11:173-180, 1993
23. Kawano S, Tsuji M, Sato N, Kamada T: A role of ammonia in Campylobacter pylori induced gastric mucosal damage. Gastroenterology 96:A252, 1988 (abstract)
24. Armstrong WM: Cellular mechanisms of ion transport in the small intestine. In Physiology of the Gastrointestinal Tract. LR Johnson (ed). New York, Raven Press, 1987, pp 1251-1270
25. Takeuchi K, Ohuchi T, Harada H, Okabe S: Irritant and protective action of urea-urease ammonia in rat gastric mucosa. Different effects of ammonia and ammonium ion. Dig Dis Sci 40:(2)274-281, 1995
26. Murakami M, Saita H, Teramura S, Dekigai H, Asagoe K, Kusaka S, Kita T: Gastric ammonia has a potent ulcerogenic action on the rat stomach. Gastroenterology 105:1710-1715, 1993
27. Riddell RH: Helicobacter pylori - some what, why, and how morphologic issues. Scand J Gastroenterol 26(suppl 187):87-84, 1991
28. Turnberg LA: Gastric mucus, bicarbonate and pH gradients in mucosal protection. Clin Invest Med 10:178-180, 1987
29. Wallace JL, Bell CJ: Gastroduodenal mucosal defense. Curr Opin Gastroenterol 9:902-908, 1993
30. Rapier RC, Dreilinger AD, Nyberg LM, Koss MA, Hogan DL, Isenberg JI: Helicobacter pylori diminishes proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer disease. Gastroenterology 106:(4)A164, 1994 (abstract)
31. Cussac V, Ferrero RL, Labigne A: Expression of Helicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions. J Bacteriol 174:2466, 1992
32. Evans DJ, Evans DG, Kirkpatrick SS, Graham DY: Characterization of the Helicobacter pylori urease and purification of its subunits. Microb Pathogen 10:15-26, 1991
33. Ormand JE, Talley NJ: Campylobacler pylori, mucus, and peptic ulceration. A dynamic interaction. J Clin Gastroenterol 5:492-495, 1989
34. Bauerfeind P, Foxall P, McDuff R, Mobley HLT: Expression and release of Helicobacter pylori urease at various pH levels. Am J Gastroenterol 89:(8)1285, 1994 (abstract)
35. Talley NJ, Ormand JE, FHe CA, Zinsmeister AR: Stability of pH gradients in vivo across the stomach in Helicobacter pylori gastritis, dyspepsia, and health. Am J Gastroenterol 87:(5)590-594, 1992