Degeneration of human oncogenes and mitochondrial genes occurs in cells that exhibit age-related pathology

Experimental Gerontology

Volumn 31, Issue 1-2, 1996, Pages 253-265

  Cortopassi, Gino ^a   Liu, Yafei ^a   Hutchin, Timothy ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

aging; Bcl 2; mitochondria; non Hodgkin's lymphoma; PCR; programmed cell death; somatic mutation assays

Indexed keywords

CARCINOGEN; CIGARETTE SMOKE; DNA; DOPAMINE; HYDROGEN PEROXIDE; MITOCHONDRIAL DNA; OXYGEN; PROTEIN P53; SUPEROXIDE; SUPEROXIDE DISMUTASE;

AGING; ARTICLE; CANCER RISK; CELL DEATH; CELL DEGENERATION; DNA REPLICATION; DOSE RESPONSE; GENE; GENE DELETION; GENE MUTATION; GENOTYPE; HUMAN; LYMPHOMA; MITOCHONDRION; NONHUMAN; ONCOGENE; PARKINSONISM; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC MUTATION; SUBSTANTIA NIGRA; SUNLIGHT;

EID: 0029924533     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/0531-5565(95)00021-6     Document Type: Article

References (43)

1. ARMITAGE, P. and DOLL, R. The age distribution of cancer and a multistage theory of carcinogenesis. Br. J. Cancer 8, 1-9, 1954.
2. ARNHEIM, N. and CORTOPASSI, G.A. Deleterious mitochondrial mutations accumulate in aging human tissue. Mutat. Res. 275, 157-167, 1992.
3. ASTER, J.C., KOBAYASHI, Y., SHIOTA, M., MORI, S., and SKLAR, J. Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients. Am. J. Pathol. 141, 291-299, 1992.
4. BAKHSHI, A., JENSEN, J.P., GOLDMAN, P. WRIGHT, J.J., McBRIDE, O.W., EPSTEIN, A.L., and S.J. KORSMEYER, S.J. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 47, 899-906; 1985.
5. BELL, D., LIU, Y., and CORTOPASSI, G.A. bcl-2 oncogene translocation occurs with increased frequency in the peripheral blood of heavy smokers. JNCI 87, 223-224, 1995.
6. BROWN, L.M., EVERETT, G.D. GIBSON, R. BURMEISTER, L.F., SCHUMAN, L.M., and BLAIR, A. Smoking and risk of nonHodgkin's lymphoma and multiple myeloma. Cancer Causes Control 3, 49-55, 1992.
7. CHANCE, B., SIES, H., and BROVERIS, A. Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59, 527-605, 1979.
8. CLEETER, M. W., COOPER, J.M., and SCHAPIRA, A.H. Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: Evidence for free radical involvement. J. Neurochem. 58, 786-789, 1992.
9. CORRAL-DEBRINSKI, M., STEPIEN, G., SHOFFNER, J.M., LOTT, M.T., KANTER, K., and WALLACE, D.C. Hypoxemia is associated with mitochondrial DNA damage and gene induction: Implications for cardiac disease. JAMA 266, 1812-1816, 1991.
10. CORRAL-DEBRINSKI, M., HORTON, T., LOTT, M.T., SHOFFNER, J.M., BEAL, M.F., and WALLACE, D.C. Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age. Nature Genet. 2, 324-329, 1990.
11. CORTOPASSI, G.A. and ARNHEIM, N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acid Res. 18, 6972-6933, 1990.
12. CORTOPASSI, G.A. and ARNHEIM, N. Using the polymerase chain reaction to estimate mutation frequencies and rates in human cells. Mutat. Res. 18, 6927-6933, 1992.
13. CORTOPASSI, G.A., SHIBATA, D., SOONG, N.W., and ARNHEIM, N. A pattern of accumulation of somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. USA 89, 7370-7374, 1992.
14. CORTOPASSI, G.A. and WANG, E. Modeling the effects of age-related mtDNA mutation accumulation; Complex I deficiency, superoxide and cell death. Biochim. Biophys. Acta 1271, 171-176, 1995.
15. CRESCENZI, M., SETO, M., HERZIG, G.P., WEISS, P.D., GRIFFITH, R.C., and KORSMEYER, S.J. Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease. Proc. Natl. Acad. Sci. USA 85, 4869-4873, 1988.
16. DEVESA, S.S. and FEARS, T. Non-Hodgkin's lymphoma time trends: United States and international data. Cancer Res. 52, 5432s-5440s, 1992.
17. DiMAURO, S. and WALLACE, D.C. Mitochondrial DNA in Human Pathology, Raven Press, New York, 1993.
18. FEARON, E.R. and VOGELSTEIN, B. A genetic model for colorectal tumorgenesis. Cell 61, 759-767, 1990.
19. HARMAN, D. The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20, 145-147, 1972.
20. HARVEY, P.H., MARTIN, R.D., and CLUTTON-BROCK, T.H. In: Primate Societies, Smuts, B.B, Cheney, D.L., Seyfarth, R.M., Wrangham, R.W., and Struhsaker, T.T. (Editors), p. 185, University of Chicago Press, Chicago, 1987.
21. HOCKENBERRY, D.M., OLTVAI, Z.N., YIN, X., MILLIMAN, C.L., and KORSMEYER, S.J. Bcl-2 functions in an antiexidant pathway to prevent apoptosis. Cell 75, 241-251, 1993.
22. HOLT, I.J., HARDING, A.E., and MORGAN-HUCHES, J.A. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 331, 717-719, 1988.
23. LEE, W.H., BOOKSTEIN, R., HONG, F., YOUNG, L.H., SHEW, J.Y., and LEE, E.Y.H.P. Human retinoblastoma susceptibility gene: Cloning identification and sequence. Science 241, 1394-1399, 1987.
24. LIMPENS, J., DE JONG, D., VAN KEIRKEN, J.H.J.M., PRICE, C.G.A., YOUNG, B.D., VAN OMMEN, G.B., and KLUIN, P.M. Bcl2/JH rearrangements in benign lymphoid tissues with follicular hyperplasia. Oncogene 6, 2271-2276, 1991.
25. LINET, M.S., McLAUGHLIN, J.K., HSING, A.W., WACHOLDER, S., CHIEN, H.T.C., SCHUMAN, L.M., BJELKE, E., and BLOT, W.J. Is cigarette smoking a risk factor for non-Hodgkin's lymphoma or multiple myeloma? Results from the Lutheran brotherhood cohort study. Leukemia Res. 16, 621-624, 1992.
26. LIU, Y., HERNANDEZ, T., SHIBATA, D., and CORTOPASSI, G.A. BCL2 translocation frequency rises with age in humans. Proc. Natl. Acad. Sci. USA 91, 8910-8914, 1994.
27. LOEB, L.A., PRESTON, B.D., SNOW, E.T., and SCHAAPER, R.M. Apurinic sites as common intermediates in mutagenesis. Basic Life Sci. 38, 341-347, 1986.
28. MASUI, T., YOAKUM, G.H., LECHNER, J.F., WILLEY, J.C., AMSTAD, P., TRUMP, B.T., and HARRIS, C.C. In vitro carcinogenesis studies of human bronchial epithelial cells. In: Mechanisms in Tobacco Carcinogenesis, Hoffmann, D. and Harris, C.C. (Editors), Cold Spring Harbor Laboratory, New York, 1986.
29. MEDVEDEV, Z.A. An attempt at a rational classification of theories of aging. Biol. Rev. 65, 375-398, 1990.
30. MUNSCHER, C., MULLER-HOCKER, J., and KADENBACH, B. Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA. Biol. Chem. Hoppe-Seyler, 374, 1099-1104, 1993.
31. NAKAZAWA, H., D. ENGLISH, D., RANDELL, P.L., NAKAZAWA, K., MARTEL, N., ARMSTRONG, B.K., and YAMASAKI, H. UV and skin cancer: Specific p53 gene mutation in normal skin as a biologically relevant exposure measurement. Proc. Natl. Acad. Sci. USA 91, 360-36 1994.
32. OLTVAI, Z.N., MILLIMAN, C.L., and KORSMEYER, S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 74, 609-619, 1993.
33. SAIKI, R.K., SCHARF, S., FALOONA, F., MULLIS, K.B., HORN, G.T., ERLICH, H.A., and ARNHEIM, N. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230, 1350-1354, 1985.
34. SCHWARTZ, G.G. Chromosomal aberrations. In: Biological Markers in Epidemiology, Hulka, B.S., Eilcosky, T.C., and Griffith, J.D. (Editors), Oxford University Press, New York, 1990.
35. SETO, M., JAEGER, U., HOCKETT, R.D., GRANINGER, W., BENNETT, S., GOLDMAN, P., and KORSMEYER, S.L. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J. 7, 123-131, 1988.
36. SIMONETTI, S., CHEN, X., DiMAURO, S., and SCHON, E.A. Accumulation of deletions in human mitochondrial DNA during normal aging: Analysis by quantitative PCR. Biochim. Biophys. Acta 1180, 113-122, 1992.
37. SOONG, N.W., HINTON, D.R., CORTOPASSI, G.A., and ARNHEIM, N. Mosaicism for a somatic mitochondrial DNA mutation in adult human brain. Nature Genet. 2, 318-350, 1992.
38. STRAUSS, G.H. and ALBERTINI, R.J. Enumeration of 6-thioguanine resistant peripheral blood lymphocytes in man as a potential test for somatic mutations arising in vivo. Mutat. Res. 61, 353-379, 1979.
39. SZILARD, L. On the nature of the aging process. Proc. Natl. Acad. Sci. USA 45, 35-40, 1959.
40. TSUJIMOTO, Y., FINGER, L.R., TUNIS, J., NOWELL, P.C., and CROCE, C.M. Cloning of the chromosomic breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226, 11097-1099, 1984.
41. TURRENS, J.K. and BOVERIS, A. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem. J. 191, 421-427, 1980.
42. WANG, E. and CORTOPASSI, G.A. Mice with duplications and deletions at the Tme locus have altered MnSOD activity. J. Biol. Chem. 269, 22463-22465, 1994.
43. YUNIS, J.J., FREZZERA, G., OKEN, M.M., McKENNA, J., THEOLOGIDES, A., and ARNESEN, M. Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer. N. Engl. J. Med. 316, 79-84, 1987.