Distribution and excretion of sumatriptan in human milk

British Journal of Clinical Pharmacology

Volumn 41, Issue 3, 1996, Pages 217-221

  Wojnar Horton, R E ^a   Hackett, L P ^b   Yapp, P ^a   Dusci, L J ^b   Paech, M ^a   Ilett, K F ^b,c  

^a KING EDWARD MEMORIAL HOSPITAL   (Australia)

^b Western Australian Centre for Pathology and Medical Research   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Breast milk; Lactation; Milk:plasma ratio; Pharmacokinetics; Sumatriptan

Indexed keywords

SUMATRIPTAN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BREAST MILK; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG MILK LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; VOLUNTEER;

EID: 0029924425     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1996.tb00185.x     Document Type: Article

References (19)

1. Plosker GL, McTavish D, Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs 1994; 47: 622-651.
2. Humphrey PP, Feniuk W. Mode of action of the anti-migraine drug sumatriptan. Trends Pharmacol Sci 1991; 12: 444-446.
3. Fullerton T, Gengo FM. Sumatriptan: a selective 5-hydroxytryptamine receptor agonist for the acute treatment of migraine. Annals Pharmacother 1992; 26: 800-808.
4. Ferrari MD, Saxena PR. Clinical and experimental effects of sumatriptan in humans. Trends Pharmacol Sci 1993; 14: 129-133.
5. Fowler PA, Lacey LF, Thomas M, Keene ON, Tanner RJ, Baber NS. The clinical pharmacology, pharmacokinetics and metabolism of sumatriptan. Eur Neurol 1991; 31: 291-294.
6. Glaxo Australia Pty Ltd. Data on file for sumatriptan. 1993.
7. Lacey LF, Hussey EK, Fowler PA. Single dose pharmacokinetics if sumatriptan in healthy volunteers. Eur J Clin Pharmacol 1995; 47: 543-548.
8. Andrew PD, Birch HL, Phillpot DA. Determination of sumatriptan succinate in plasma and urine by high-performance liquid chromatography with electrochemical detection. J Pharm Sci 1995; 82: 73-76.
9. Ilett KF, Lebedevs TH, Wojnar-Horton RE, et al. The excretion of dothiepin and its primary metabolites in breast milk. Br J Clin Pharmacol 1993; 33: 635-639.
10. Thomann P. Non-compartmental analysis methods manual. TOPFIT Version 2 Pharmacokinetic and pharmacodynamic data analysis system for the PC. Heinzel G, Woloszczak R, and Thomann P. Gustav Fischer, Stuttgart, 1993; Part 2, pp 5-66.
11. Allen JC, Keller RP, Archer P, Neville MC. Studies in human lactation: milk composition and daily secretion rates of macronutrients in the first year of lactation. Am J Clin Nutr 1991; 54: 69-80.
12. Dixon CM, Saynor DA, Andrew PD, Oxford J, Bradbury A, Tarbit MH. Disposition of sumatriptan in laboratory animals and humans. Drug Metab Dispos 1993; 21: 761-769.
13. Humphrey PPA, Wasyl F, Perren MJ, Skingle M, Beresford IJM, Whalley ET. Serotonin and migraine. Ann NY Acad Sci 1990; 600: 587-600.
14. Bennett PN, and the WHO Working Group. Drugs and human lactation. First edn. Elsevier, Amsterdam, 1988.
15. Begg EJ, Atkinson HC. Partitioning of drugs into human milk. Ann Acad Med Singapore 1991; 20: 51-55.
16. Begg EJ, Atkinson HC, Duffull SB. Prospective evaluation of a model for the prediction of milk: plasma drug concentrations from physicochemical characteristics. Br J Clin Pharmacol 1992; 33: 501-505.
17. Begg EJ, Atkinson HC. Modelling of the passage of drugs into milk. Pharmacol Ther 1993; 59: 301-310.
18. Atkinson HC, Begg EJ. Prediction of drug distribution into human milk from physicochemical characteristics. Clin Pharmacokinet 1990; 18: 151-167.
19. Wilson JT. Drugs in breast milk. ADIS Press, Sydney, 1981.