Systemic NMDA antagonist CGP-37849 produces non-specific impairment in a working memory task: The effect does not resemble those of AP5 and of lesions of the hippocampus or fornix

Neuropsychologia

Volumn 34, Issue 4, 1996, Pages 311-314

  Gutnikov, S A ^a   Rawlins, J N P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Behaviour; LTP; Nonspatial memory; Rat; Vicarious trial and error

Indexed keywords

2 AMINO 4 METHYL 5 PHOSPHONO 3 PENTENOIC ACID; 2 AMINO 5 PHOSPHONOVALERIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; BRAIN FORNIX; CONTROLLED STUDY; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; LONG TERM POTENTIATION; MALE; MOTOR PERFORMANCE; NONHUMAN; RAT; TASK PERFORMANCE; WORKING MEMORY;

EID: 0029924388     PISSN: 00283932     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3932(95)00113-1     Document Type: Article

References (15)

1. Aggleton, J. P. One trial object recognition by rats. Q. J. Exp. Psychol. 37B, 279-294, 1985.
2. Bliss, T. V. P. and Collingridge, G. L. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361, 31-39, 1993.
3. Butcher, S. P., Davis, S. and Morris, R. G. A dose-related impairment of spatial learning by the NMDA receptor antagonist, 2-amino-5-phosphonovalerate (AP5). Eur. Neuropsychopharmacol. 1, 15-20, 1990.
4. Collingridge, G. L., Kehl, S. J. and McLennan, H. Excitatory amino-acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J. Physiol. (Lond.) 334, 33-46, 1983.
5. Fagg, G. E., Olpe, H. R., Pozza, M. F., Baud, J., Steinmann, M., Schmutz, M., Portet, C., Baumann, P., Thedinga, K., Bittiger, H., Allgeier, H., Heckendorn, R., Angst, C., Brundish, D. and Dingwall, J. G. CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity. Br. J. Pharmacol. 99, 791-797, 1990.
6. Gutnikov, S. A. Behavioural studies of the NMDA system in rats [D.Phil. Thesis], Department of Experimental Psychology, University of Oxford, 1995.
7. Gutnikov, S. A., Barnes, J. C. and Rawlins, J. N. P. Working memory tasks in five-choice operant chambers: Use of relative and absolute spatial memories. Behav. Neurosci. 108, 899-910, 1994.
8. Lyford, G. L., Gutnikov, S. A., Clark, A. M. and Rawlins, J. N. P. Determinants of non-spatial working memory deficits in rats given intraventricular infusions of the NMDA antagonist AP5. Neuropsychologia 31, 1079-1098, 1993.
9. McNaughton, B. L. Activity dependent modulation of hippocampal synaptic efficacy: Some implications for memory processes. In The Neurobiology of the Hippocampus, W. Seifert (Editor), pp. 233-252. Academic Press, London, 1983.
10. 3H]glutamate-binding sites in rat brain. J. Neurosci. 5, 2909-2919, 1985.
11. Morris, R. G. M., Anderson, E., Lynch, G. S. and Baudry, M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319, 774-776, 1986.
12. Muenzinger, K. F. and Fletcher, F. M. Motivation in learning: VI. Escape from electric shock compared with hunger-food tension in the visual discrimination habit. J. Comp. Psychol. 22, 79-91, 1936.
13. Raffaele, K. C. and Olton, D. S. Hippocampal and amygdaloid involvement in working memory for nonspatial stimuli. Behav. Neurosci. 102, 355-369, 1988.
14. Rawlins, J. N. P., Lyford, G. L., Seferiades, A., Deacon, R. M. J. and Cassaday, H. J. Critical determinants of non-spatial working memory deficits in rats with conventional lesion of hippocampus or fornix. Behav. Neurosci. 107, 420-433, 1993.
15. Teyler, T. J. and Discenna, P. Long-term potentiation as a candidate mnemonic device. Brain Res. Rev. 7, 15-28, 1984