Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 3, 1996, Pages 1189-1196

  Thorner, Michael ^a   Rochiccioli, Pierre ^b   Colle, Michel ^c   Lanes, Roberto ^d   Grunt, Jerome ^e   Galazka, Andrew ^f   Landy, Hal ^f   Eengrand, Patrick ^f   Shah, Samir ^f  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b CHU PURPAN   (France)

^c Centre d'Endocrinologie Pediatrique   (France)

^d Hospital Central Dr Carlos Avelo   (Venezuela)

^e CHILDREN S MERCY HOSPITAL   (United States)

^f Serono International SA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RELEASING FACTOR; SERMORELIN;

ADOLESCENT; ARTICLE; BODY HEIGHT; CHILD; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; FEMALE; GROWTH ACCELERATION; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HORMONE DETERMINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADOLESCENT; ANTIBODIES; CHILD; CHILD DEVELOPMENT; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; FORECASTING; GROWTH HORMONE; HUMANS; INJECTIONS, SUBCUTANEOUS; SERMORELIN; TIME FACTORS; TREATMENT OUTCOME;

EID: 0029924189     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.3.1189     Document Type: Article

References (47)

1. Guillemin R, Brazeau P, Bohlen P, Esch F, Ling N, Wehrenberg WB. 1982 Growth hormone-releasing factor from a human pancreatic tumour that caused acromegaly. Science. 218:585-587.
2. Rivier J, Speiss J, Thorner M, Vale W. 1982 Characterization of growth hormone-releasing factor from a human pancreatic islet tumor. Nature. 300: 276-278.
3. Borges JLC, Blizzard RM, Evans WS, et al. 1983 Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin-C levels in patients with idiopathic growth hormone deficiency. Lancet. 2:119-124.
4. Grossman A, Savage MO, Wass JAH, et al. 1983 Growth hormone-releasing factor in growth hormone deficiency: demonstration of a hypothalamic defect in growth hormone release. Lancet. 2:127-138.
5. Thorner MO, Reschke J, Chitwood J, et al. 1985 Acceleration of growth in two children treated with human growth hormone-releasing factor. N Engl J Med. 312:4-9.
6. Romer TE, Rymkiewicz-Kluczynska B, Olivier M, Sagnard L, Szarras-Czapnik M.. 1991 Growth hormone-releasing hormone reverses secondary somatotroph unresponsiveness. J Clin Endocrinol Metab. 72:503-506.
7. Butenandt O, Staudt B.. 1989 Comparison of growth hormone releasing hormone therapy and growth hormone therapy in growth hormone deficiency. Eur J Pediatr. 148:393-395.
8. Ross RJM, Rodda C, Tsagarakis S, et al. 1987 Treatment of growth-hormone deficiency with growth hormone releasing hormone. Lancet. 1:5-8.
9. Bozzola M, Biscaldi I, Cisternino M, et al. 1990 Long-term growth hormone-releasing hormone and biosynthetic GH therapy in GH-deficient children: comparison of therapeutic effectiveness. J Endocrinol Invest. 13:153-163.
10. Low LCK, Wang C, Cheung PT, et al. 1988 Long term pulsatile growth hormone-releasing hormone therapy in children with GH deficiency. J Clin Endocrinol Metab. 66:611-617.
11. Thorner MO, Rogol AD, Blizzard RM, et al. 1988 Acceleration of growth rate in growth hormone-deficient children treated with human growth hormone-releasing hormone. Pediatr Res. 24:145-151.
12. Wit JM, Otten BJ, Waelkens JJ, et al. 1987 Short-term effect on growth of two doses of GRF 1-44 in children with growth hormone deficiency: comparison with growth induced by methionyl-GH administration. Horm Res. 27:181-189.
13. Duck SC, Schwarz HP, Costin G, et al. 1992 Subcutaneous growth hormone-releasing hormone therapy in growth hormone-deficient children: first year of therapy. J Clin Endocrinol Metab. 75:1115-1120.
14. Rochiccioli PE, Tauber M-T, Coude F-X, et al. 1987 Results of 1-year growth hormone-releasing hormone (1-44) treatment on growth, somatomedin C, and 24-hour GH secretion in six children with partial GH deficiency. J Clin Endocrinol Metab. 65:268-274.
15. Lanes R, Carrillo E, Venezuelan Collaborative Study Group. 1994 Long term therapy with a single daily subcutaneous dose of growth hormone releasing hormone (1-29) in prepubertal growth hormone deficient children. J Pediatr Endocrinol. 7:303-308.
16. Tanner JM, Whitehouse, RH, Takishi M. 1966 Standards from birth to maturity for height, weight, height velocity, weight velocity. British children, 1965. Arch Dis Child. 41:613-635.
17. Sempé M, Pédron G, Roy-Pernot MP. 1979 Auxologie/méthode et séquences. Paris: Theraplix; 25-26.
18. Hernandez M, Castellet J, Narvalza JL, et al. 1981 Crecimiento y Desarollo; Publicaciones del Instituto de Crecimiento y Desarollo de la Fundation F. Bilbao: Orbegozo.
19. Hamill VV, Drizd TA, Johnson CL, Reed RB, Roche AF, Moore WM. 1979 Physical growth: National Center for Health Statistic Percentiles. Am J Clin Nutr. 32:607-629.
20. Prader A, Largo RH, Molinari, L, Isseler C. 1989 Physical growth of Swiss children from birth to 20 years of age. Helv Pediatr Acta. 52(Suppl):1-125.
21. Greulich WW, Pyle SI. 1959 Radiographic atlas of skeletal development of the hand and wrist. Stanford: Stanford University Press.
22. Marshall WA, Tanner JM. 1969 Variations in the pattern of pubertal changes in girls. Arch Dis Child. 44:291.
23. Marshall WA, Tanner JM. 1970 Variation in the pattern of pubertal changes in boys. Arch Dis Child. 45:13.
24. Zachmann M, Prader A, Kind HP, Halfliger H, Budlinger H. 1974 Testicular volume during adolescence: cross-sectional and longitudinal studies. Helv Pediatr Acta. 29:61.
25. Desbuquois B, Aurbach GD. 1971 Use of polyethylene glycol to separate free and antibody-bound peptide hormones. J Clin Endocrinol Metab. 33:732-738.
26. Petersen KG, Zeisel HJ, Kerp L. 1989 The immune response to GHRH, relationship to conformation. Horm Metab Res. 21:427-430.
27. 2): Immunoreactive plasma levels after intravenous and subcutaneous administration. J Endocrinol. 107:R5-R8.
28. Machin D, Campbell MJ. 1987 Statistical tables for the design of clinical trials. Boston: Blackwell.
29. Frasier D. 1983 Human pituitary growth hormone (hGH) therapy in growth hormone deficiency. Endocr Rev. 4:155-170.
30. Ranke MD, Blank B. 1990 Is there an auxological basis for growth promoting treatment with human growth hormone in short children? Acta Pediatr Scand. 367(Suppl):4-10.
31. Brain CE, Hindmarsh PC, Brook CDG. 1990 Continuous GHRH (1-29) NH promotes growth over 1 year in short, slowly growing children. Clin Endocrinol (Oxf). 32:153-163.
32. Lievre M, Chatelain P, Van Vliet G, et al. 1992 Treatment with growth hormone-releasing hormone (GHRH) 1-44 in children with idiopathic growth hormone deficiency: a randomised double-blind dose-effect study. Fund Clin Pharmacol. 6:359-366.
33. Iovino M, Monteleone P, Steardo L. 1989 Repetitive growth hormone-releasing hormone administration restores the attenuated growth hormone (GH) response to GH-releasing hormone testing in normal aging. J Clin Endocrinol Metab. 69:910-913.
34. Rosenfeld RG, Kemp SF, Hintz RL. 1981 Constancy of somatomedin response to growth hormone treatment of hypipituitary dwarfism. J Clin Endocrinol Metab. 53:611-617.
35. Neyzi O, Yordam N, Ocal G, et al. 1993 Growth response to growth hormone-releasing hormone (1-29)-NH2 compared with growth hormone. Acta Pediatr. 388(Suppl):16-21.
36. Chen RG, Shen YN, Yei J, et al. 1993 A comparative study of growth hormone (GH) and GH-releasing hormone (1-29)-NH2 for stimulation of growth in children with GH deficiency. Acta Pediatr. 388(Suppl):32-35.
37. McGillivray MH, Gesunheit N, Johanson A. 1994 Outcome of a three year randomized study of three times weekly versus daily somatropin treatment in prepubertal growth hormone deficient children. Pediatr Res. 35(Suppl):601.
38. Lanzi R, Tannenbaum GS. 1992 Time dependent reduction and potentiation of Growth Hormone (GH) responsiveness to GH releasing factor induced by exogenous GH. Role of somatostatin. Endocrinology. 130:1822-1828.
39. Vance ML, Kaiser DL, Evans WS, et al. 1985 Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1-40). Evidence of intermittent somatostatin secretion. J Clin Invest. 75:1584-1590.
40. Cassorla F, Mericq V, Garcia H, et al. 1995 Co-treatment with a β1-adrenergic blocking agent enhances the growth response to growth hormone-releasing hormone (GHRH) therapy in growth hormone (GH) deficient children. J Clin Endocrinol Metab. 80:2997-3001.
41. Wehrenberg WB, Ling N, Brazeau P, et al. 1982 Somatocrinin, growth hormone releasing factor, stimulates secretion of growth hormone in anesthesized rats. Biochem Biophys Res Commun. 109:382-387.
42. Sato T, Suzuki Y, Taketani T, et al. 1977 Enhanced peripheral conversion of thyroxine to triiodothyronine during hGH therapy in GH deficient children. J Clin Endocrinol Metab. 45:324-329.
43. Lippe BM, Van Herle AJ, LaFranchi SH, Uller RP, Lavin N, Kaplan SA. 1975 Reversable hypothyroidism in growth hormone-deficient children treated with human growth hormone. J Clin Endocrinol Metab. 40:612-618.
44. LaFranchi S, Hanna CE, Illingworth DR. 1985 Effect of growth hormone replacement on development of hypothyroidism and hyperlipidemia. J Pediatr. 106:588-593.
45. Pirazzoli P, Cacciari E, Mandini M, et al. 1992 Growth and thyroid function in children treated with growth hormone. J Pediatr. 121:210-213.
46. Municchi G, Malozowski S, Nisula BC, Cristiano A, Rose S. 1992 Nocturnal thyrotropin surge in growth hormone-deficient children. J Pediatr. 121:214-220.
47. Holcombe JH, Conforti PM, Wong AC, Thompson RG, Draper MW. 1990 Biosynthetic human growth hormone in the treatment of growth hormone deficiency. Acta Pediatr Scand. 367(Suppl):44-48.