Altered sensory processing in the somatosensory cortex of the mouse mutant barrelless

Science

Volumn 271, Issue 5257, 1996, Pages 1864-1867

  Welker, E ^a,b   Armstrong James, M ^a,b   Bronchti, G ^a,b   Ourednik, W ^a,b   Gheorghita Baechler, F ^a,b   Dubois, R ^a,b   Guernsey, D L ^a,b   Van Der Loos, H ^b   Neumann, P E ^a,b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME 11; CONTROLLED STUDY; GENE MAPPING; GENE MUTATION; HOMOZYGOTE; MOUSE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE; SOMATOSENSORY CORTEX; THALAMUS; TIME PERCEPTION;

ANIMALIA;

EID: 0029923726     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5257.1864     Document Type: Article

References (35)

1. D H Hubel and T. N Wiesel, J. Comp. Neurol. 146, 421 (1972), S. Levay, D. H. Hubel, T. N. Wiesel, ibid. 159, 559 (1975); S. Levay, M. P. Stryker, C. J. Shatz, ibid. 179, 223 (1978), M. P Stryker and W. A. Harris, J. Neurosci 6, 2117 (1986).
2. D H Hubel and T. N Wiesel, J. Comp. Neurol. 146, 421 (1972), S. Levay, D. H. Hubel, T. N. Wiesel, ibid. 159, 559 (1975); S. Levay, M. P. Stryker, C. J. Shatz, ibid. 179, 223 (1978), M. P Stryker and W. A. Harris, J. Neurosci 6, 2117 (1986).
3. D H Hubel and T. N Wiesel, J. Comp. Neurol. 146, 421 (1972), S. Levay, D. H. Hubel, T. N. Wiesel, ibid. 159, 559 (1975); S. Levay, M. P. Stryker, C. J. Shatz, ibid. 179, 223 (1978), M. P Stryker and W. A. Harris, J. Neurosci 6, 2117 (1986).
4. D H Hubel and T. N Wiesel, J. Comp. Neurol. 146, 421 (1972), S. Levay, D. H. Hubel, T. N. Wiesel, ibid. 159, 559 (1975); S. Levay, M. P. Stryker, C. J. Shatz, ibid. 179, 223 (1978), M. P Stryker and W. A. Harris, J. Neurosci 6, 2117 (1986).
5. T. A. Woolsey and H. Van der Loos, Brain Res. 17, 205 (1970), T. A. Woolsey, C. Welker, R. H Schwartz, J. Comp. Neurol. 164, 79 (1975).
6. T. A. Woolsey and H. Van der Loos, Brain Res. 17, 205 (1970), T. A. Woolsey, C. Welker, R. H Schwartz, J. Comp. Neurol. 164, 79 (1975).
7. D J. Simons, J. Neurophysiol. 54, 615 (1985); M. Armstrong-James and K. Fox, J.Comp. Neurol 263, 265 (1987).
8. D J. Simons, J. Neurophysiol. 54, 615 (1985); M. Armstrong-James and K. Fox, J.Comp. Neurol 263, 265 (1987).
9. M Armstrong-James, C. A. Callahan, M. A. Friedman, J. Comp. Neurol 303, 193 (1991), K. Fox, J Neurosci, 14, 7665 (1994).
10. M Armstrong-James, C. A. Callahan, M. A. Friedman, J. Comp. Neurol 303, 193 (1991), K. Fox, J Neurosci, 14, 7665 (1994).
11. R Lorente de Nó, Trab Lab. Invest. Biol. Univ. Madrid 20, 41 (1922); K F. Jensen and H. P. Killackey, J Neurosci. 7, 3529 (1987).
12. R Lorente de Nó, Trab Lab. Invest. Biol. Univ. Madrid 20, 41 (1922); K F. Jensen and H. P. Killackey, J Neurosci. 7, 3529 (1987).
13. S. L. Senft and T. A Woolsey, Cerebr. Cortex 1, 308 (1991); A Agmon, L. T Yang, D. K O'Dowd, E. G. Jones, J. Neurosci. 13, 5365 (1993).
14. S. L. Senft and T. A Woolsey, Cerebr. Cortex 1, 308 (1991); A Agmon, L. T Yang, D. K O'Dowd, E. G. Jones, J. Neurosci. 13, 5365 (1993).
15. R. S. Erzurumlu and S. Jhaven, Dev. Brain Res 56, 229 (1990); M. E. Blue, R. S Erzurumlu, S. Jhaveri, Cerebr. Cortex 1, 380 (1991); S Jhaven, R. S. Erzurumlu, K Crossin, Proc. Natl. Acad. Sci. U S.A. 88, 4489 (1991); B L Schlaggar and D. D. M. O'Leary, J. Comp. Neurol. 346, 90 (1994).
16. R. S. Erzurumlu and S. Jhaven, Dev. Brain Res 56, 229 (1990); M. E. Blue, R. S Erzurumlu, S. Jhaveri, Cerebr. Cortex 1, 380 (1991); S Jhaven, R. S. Erzurumlu, K Crossin, Proc. Natl. Acad. Sci. U S.A. 88, 4489 (1991); B L Schlaggar and D. D. M. O'Leary, J. Comp. Neurol. 346, 90 (1994).
17. R. S. Erzurumlu and S. Jhaven, Dev. Brain Res 56, 229 (1990); M. E. Blue, R. S Erzurumlu, S. Jhaveri, Cerebr. Cortex 1, 380 (1991); S Jhaven, R. S. Erzurumlu, K Crossin, Proc. Natl. Acad. Sci. U S.A. 88, 4489 (1991); B L Schlaggar and D. D. M. O'Leary, J. Comp. Neurol. 346, 90 (1994).
18. R. S. Erzurumlu and S. Jhaven, Dev. Brain Res 56, 229 (1990); M. E. Blue, R. S Erzurumlu, S. Jhaveri, Cerebr. Cortex 1, 380 (1991); S Jhaven, R. S. Erzurumlu, K Crossin, Proc. Natl. Acad. Sci. U S.A. 88, 4489 (1991); B L Schlaggar and D. D. M. O'Leary, J. Comp. Neurol. 346, 90 (1994).
19. S. M. Catalano, R. T. Robertson, H P. Killackey, Proc. Natl. Acad. Sci US.A 92, 2549 (1995); K. F. Jensen and H. P Killackey, J. Neurosci. 7, 3544 (1987).
20. S. M. Catalano, R. T. Robertson, H P. Killackey, Proc. Natl. Acad. Sci US.A 92, 2549 (1995); K. F. Jensen and H. P Killackey, J. Neurosci. 7, 3544 (1987).
21. H Van der Loos, E. Welker, J. Dörfl, G. Rumo, J. Hered. 77, 66 (1986).
22. W. F. Dietrich et al., Nature Genet. 7, 220 (1994).
23. G R. Belford and H. P. Killackey, J. Comp. Neurol. 183, 305 (1979); P. M. Ma, ibid. 309, 161 (1991)
24. G R. Belford and H. P. Killackey, J. Comp. Neurol. 183, 305 (1979); P. M. Ma, ibid. 309, 161 (1991)
25. H Van der Loos, Neurosci. Lett 2, 1 (1976).
26. D Durham and T. A Woolsey, J. Comp. Neurol. 223, 424 (1984).
27. O. Cases et al., Science 268, 1763 (1995)
28. Experimental procedures were approved by the Office Véténnair Cantonal (Lausanne), in accordance with Swiss laws. Tracers were injected in adult mice that were anesthetized with Nembutal (60 mg of sodium pentobarbital per kilogram of body mass, intraperitoneal) and placed in a stereotaxic frame. Biotinylated dextran (5% in water) was iontophoretically injected (2 μA of positive current, 7 s on and 7 s off for 15 min) through a glass pipette (diameter, 20 μM) Biocytin (2% in 1 M potassium acetate) was iontophoretically injected (150 nA of positive current, 1 s on and 1 s off for 10 to 15 min) through a pipette with a diameter of 1 to 3 μm After a survival period of 1 week (dextran) or 24 hours (biocytin), mice were deeply anesthetized and processed as described [M. J. Dolleman-Van der Weel, F G Wouterlood, M. P Witter, J. Neurosci Methods 51, 9 (1994)] The injection site was verified histologically
29. 14C]deoxy-D-glucose (16.5 μCi per 100 g of body mass) and placed in an obiect-filled cage for 45 min, after which they were anesthetized and their brains processed for autoradiography [E. Welker, S B. Rao, J. Dorfl, P. Melzer, H Van der Loos, J. Neurosci. 12, 153 (1992)].
30. Recordings were made from mice under urethane anesthesia (2 mg per gram of body mass, administered by intraperitoneal injections of a 10% solution in distilled water). Units were situated 350 to 480 μm below the pial surface. The center whisker was defined as that giving the largest response magnitude. Data for the surround whisker refer to the one with the shortest latency. Response magnitudes were measured by the mean number of spikes generated per 50 deflections [E Welker, M. Armstrong-James, H. Van der Loos, R. Kraftsik, Eur. J. Neurosci. 5, 691 (1993)].
31. M. Cohen-Tannoudji, C. Babinet, M. Wassef, Nature 368, 460 (1994).
32. E Garraghty and M. Sur, J. Comp. Neurol. 294, 583 (1990).
33. C. Von der Malsburg, in The Neural and Molecular Bases of Learning, J -P Changeux and M. Konishi, Eds (Wiley, New York, 1987), pp. 411-431.
34. M. Wong-Riley, Brain Res. 171, 11 (1979).
35. Our dear collaborator Hendrik Van der Loos died in October 1993 We thank N. Trapp and G. Skabardonis for technical assistance and S Catsicas, P. G. H. Clarke, A Fine, J.-P. Homung, G. M. Innocenti, and J. H. Kaas for comments on the manuscript. Supported by the Swiss National Science Foundation (grant 31-39184), the Wellcome Trust (M.A.-J.), and the Medical Research Council of Canada (grant MT-12941).