Hypothalamic lesions induce obesity and sex-dependent glomerular damage and increases in blood pressure in rats

Hypertension

Volumn 27, Issue 4, 1996, Pages 926-932

  Baylis, Chris ^a,c   Samsell, Lennie ^a   Racusen, Lorraine ^b   Gladfelter, Wil ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

glomerulus; hypothalamus; lipids; obesity; renal hemodynamics

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ANIMAL MODEL; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; FEEDING BEHAVIOR; FEMALE; GLOMERULOPATHY; HYPERLIPIDEMIA; HYPOTHALAMUS; KIDNEY BLOOD FLOW; LIPID BLOOD LEVEL; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAT; RENOVASCULAR HYPERTENSION; RISK FACTOR; SEX DIFFERENCE;

EID: 0029923377     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.27.4.926     Document Type: Article

References (40)

1. Hall JE. Renal and cardiovascular mechanisms of hypertension in obesity. Hypertension. 1994;23:381-394.
2. Jennette JC, Charles L, Grubb W. Glomerulomegaly and focal segmental glomerulosclerosis associated with obesity and sleep apnea syndrome. Am J Kidney Dis. 1987;10:470-472.
3. Warnke RA, Kempson RL. The nephrotic syndrome in massive obesity: a study by tight, immunofluorescence and electron microscopy. Arch Pathol Lab Med. 1978;102:431-438.
4. Kasiske BL, O'Donnell MP, Cleary MP, Keane WF. Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats. Kidney Int. 1988;33:667-672.
5. Keane WF, Kasiske BL, O'Donnell MP, Schmitz PG. Therapeutic implications of lipid-lowering agents in the progression of renal disease. Am J Med. 1989;87:5-21N-5-24N.
6. Diamond JR. Hyperlipidemia of nephrosis: pathophysiologic role in progressive glomerular disease. Am J Med. 1989;87:5-25N-5-29N.
7. Olson JL, Wilson SK, Heptinstall RH. Relation of glomerular injury to preglomerular resistance in experimental hypertension. Kidney Int. 1986;29:849-857.
8. Os I, Kjeldsen SE, Norby G, Eide I, Lande K, Hjermann J, Westheim A. Sex differences in essential hypertension. J Intern Med. 1993;233:13-19.
9. Freedman DS, Jacobsen SJ, Barboriak JJ, Sobocinski KA, Anderson AJ, Kissebach AH, Sasse EA, Gruchow HW. Body fat distribution and male/female differences in lipids and lipoproteins. Circulation. 1990;81:1498-1506.
10. Baylis C. Age-dependent glomerular damage in the rat: dissociation between glomerular injury and both glomerular hypertension and hypertrophy: male gender as a primary risk factor. J Clin Invest. 1994;94:1823-1829.
11. Brobeck JR, Tepperman J, Long CNH. Experimental hypothalamic hyperphagia in the albino rat. Yale J Biol Med. 1943;15:831-853.
12. Reisin E, Wilson JR, Frohlich ED. Hypertension and obesity in rats with ventromedial-hypothalamic lesions and low salt intake. J Hypertens. 1987;5:173-178.
13. Konig JFR, Klippel RA. The Rat Brain: A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stein. New York. NY: Williams & Wilkins Co: 1963.
14. Pedegrino LJ, Pellegrino AS, Cushman AJ. A Stereotaxic Atlas of the Rat Brain. New York, NY: Plenum Publishing Corp; 1967.
15. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
16. Baylis C, Deen WM, Myers B, Brenner BM. Effects of some vasodilator drugs on transcapillary fluid exchange in renal cortex. Am J Physiol. 1976;230:1148-1158.
17. Lowry OH, Rosebrough NJ, Farr AJ, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
18. Kluver H, Berrera E. A method for the combined staining of cells and fibers in the nervous system. J Neuropathol Exp Neurol. 1953;12:400-403.
19. Munger K, Baylis C. Sex differences in renal hemodynamics in rats. Am J Physiol. 1988;254:F223-F231.
20. Baylis C, Foulks C, Samsell L, Engels K. Short term natriuretic responses in the conscious Zucker obese rat. Clin Exp Hypertens A. 1991;13:1153-1167.
21. Chen Y-F, Meng Q-C. Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent. Life Sci. 1991;48:85-96.
22. Ashton N, Balment RJ. Sexual dimorphism in renal function and hormonal status of New Zealand genetically hypertensive rats. Acta Endocrinol. 1991;124:91-97.
23. Crofton JT, Share L, Brooks DP. Gonadectomy abolishes the sexual dimorphism in DOC-salt hypertension in the rat. Clin Exp Hypertens A. 1989;11:1249-1261.
24. Malyusz M, Ehrens HJ, Wrigge P. Effect of castration on the experimental renal hypertension in the rat. Nephron. 1985;40:96-99.
25. Brenner BM. Nephron adaptation to renal injury or ablation. Am J Physiol. 1985;249:F324-F337.
26. O'Donnell MP, Kasiske BL, Cleary MP, Keane WF. Effects of genetic obesity on renal structure and function in the Zucker rat, II: micropuncture studies. J Lab Clin Med. 1985;106:605-610.
27. Schmitz PG, O'Donnell MP, Kasiske BL, Katz SA, Keane WF. Renal injury in obese Zucker rats: glomerular hemodynamic alterations and effects of enalapril. Am J Physiol. 1992;263:F496-F502.
28. Daniels BS, Hostetter TH. Adverse effects of growth in the glomerular microcirculation. Am J Physiol. 1990;258:F1409-F1416.
29. Gray JE, van Zwieten MJ, Hollandes CF. Early light microscopic changes of chronic progressive nephrosis in several strains of aging laboratory rats. J Gemntol. 1982;37:142-150.
30. Yee WW, Takahashi S, Kawashima S. Age-related changes and sex difference in Ihe ultrastructure of renal glomerulus in Wistar/Tw rats. Zoological Sci. 1989;6:777-788.
31. Riedel M, Rafflenbeul W, Lichtlen P. Ovarian sex steroids and atherosclerosis. Clin Pharmacol. 1993;71:406-412.
32. Baylis C, Wilson CB. Sex and the single kidney. Am J Kidney Dis. 1989;13:290-298.
33. Lombet JR. Adler SG, Anderson PS, Nast CC, Olsen DR, Glassock RJ. Sex vulnerability in the subtotal nephrectomy model of glomerulosclerosis in the rat. J Lab Clin Med. 1989;114:66-74.
34. Remuzzi A, Puntorieri S, Alfano M, Macconi D, Abbate M, Bertani T, Remuzzi G. Pathophysiologic implications of proteinuria in a rat model of progressive glomerular injury. Lab Invest. 1992;67:572-579.
35. Shimamura T. Relationship of dietary intake to the development of glomerulosclerosis in obese Zucker rats. Exp Mol Pathol. 1982;36:423-434.
36. Sakemi T, Toyoshima H, Morito F. Testosterone eliminates the attenuating effect of castration on the progressive glomerular injury in hypercholesterolemic male Imai rats. Nrphron. 1994;67:469-476.
37. Hollenberg NK, Adams DF, Solomon HS, Rashid A, Abrams HL, Merrill JP. Senescence and the renal vasculature in normal man. Circ Res. 1974;34:309-316.
38. Gretz N, Zeier M, Geberth S, Strauch M, Ritz E. Is gender a determinant for evolution of renal failure? A study of autosomal dominant polycystic kidney disease. Am J Kidney Dis. 1989;14:178-183.
39. West KM, Erdreich L, Stober JA. A detailed study of risk factors for retinopathy and nephropathy in diabetes. Diabetes. 1980;29:501-508.
40. USRDS annual data report. Am J Kidney Dis. 1990;16(suppl 2):22-27.