Aplastic anaemia patients with clonal X-chromosome inactivation pattern in haemopoietic cells exhibit polyclonal TCRγ and IgH gene rearrangements

British Journal of Haematology

Volumn 93, Issue 2, 1996, Pages 326-332

  Melenhorst, J Joseph ^a   Fibbe, Willem E ^a   Smits, Shirley ^a   Willemze, Roel ^a   Landegent, James E ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

aplastic anaemia; clonality; immunoglobulin heavy chain; T cell receptor ; X chromosome inactivation

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; T LYMPHOCYTE RECEPTOR;

ADULT; APLASTIC ANEMIA; ARTICLE; BONE MARROW CELL; CELL CLONE; CLINICAL ARTICLE; FEMALE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; X CHROMOSOME;

EID: 0029923138     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.5171060.x     Document Type: Article

References (22)

1. Allen, R.C., Zoghbi, H.Y., Moseley, A.B., Rosenblatt, H.M. & Belmont, J.W. (1992) Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. American Journal of Human Genetics, 51, 1229-1239.
2. H locus. EMBO Journal, 7, 727-738.
3. Björkholm, M. (1992) Aplastic anaemia: pathogenic mechanisms and treatment with special reference to immunomodulation. Journal of Internal Medicine, 231, 575-582.
4. Champlin, R., Winston, H.O. & Gale, R.P. (1983) Antithymocyte globulin treatment in patients with aplastic anemia. New England Journal of Medicine, 308, 113-118.
5. + cytotoxic T lymphocyte clones from a patient with severe graft-versus-host-disease after allogeneic bone marrow transplantation: implications for graft-versus-leukemia reactivity. Blood, 86, 2821-2828.
6. Fey, M.F., Liechti-Gallati, S., Von Rohr, A., Borisch, B., Theilkäs, L., Schneider, V., Oestreicher, M., Nagel, S., Ziemiecki, A. & Tobler, A. (1994) Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M27β DNA probe. Blood, 83, 931-938.
7. Gale, R.E., Wheadon, H., Goldstone, A.H., Burnett, A.K. & Linch, D.C. (1993) Frequency of clonal remission in acute myeloid leukaemia. Lancet, 341, 138-142.
8. Gascon, P., Zoumbos, N.C., Scala, G., Djeu, J.Y., Moore, J.G. & Young, N.S. (1985) Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of antithymocyte globulin. Blood, 65, 407-413.
9. Hendriks, R.W., Chen, Z.-Y., Hinds, H., Schuurman, R.K.B. & Craig, I.W. (1992) An X chromosome inactivation assay based on differential methylation of a CpG island coupled to a VNTR polymorphism at the 5′ end of the monoamine oxidase A gene. Human Molecular Genetics, 1, 187-194.
10. Josten, K.M., Tooze, J.A., Borthwick-Clarke, C., Gordon-Smith, E.C. & Rutherford, T.R. (1991) Acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria: studies on clonality. Blood, 78, 3162-3167.
11. Liang, R., Chan, V., Chan, T.K., Wong, T., Chiu, E. & Todd, D. (1991) Detection of immunoglobulin gene rearrangement in acute and chronic lymphoid leukemias of B-cell lineage by polymerase chain reaction. American Journal of Hematology, 38, 189-193.
12. Marsh, J.C.W., Chang, J., Cowling, G.J., Testa, N.G., Hows, J.M. & Dexter, T.M. (1990) Clonality studies and long-term marrow culture to assess hemopoiesis in aplastic anemia. (Abstract). Experimental Hematology, 18, 306a.
13. Miller, S.A., Dykes, D.D. & Polesky, H.F. (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Research, 16, 1215.
14. Taylor, J.J., Rowe, D., Williamson, I.K., Christmas, S.E., Proctor, S.J. & Midleton, P.G. (1991) Detection of T-cell receptor γ chain V gene rearrangements using the polymerase chain reaction: application to the study of clonal disease cells in acute lymphoblastic leukemia. Blood, 77, 1989-1995.
15. Trainor, K.J., Brisco, M.J., Wan, J.H., Neoh, S., Grist, S. & Morley, A.A. (1991) Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood, 78, 192-196.
16. Tsuge, I., Kojima, S., Matsuoka, H., Abe, T., Kamachi, Y., Torii, S. & Matsuyama, T. (1993) Clonal haemopoiesis in children with acquired aplastic anaemia. British Journal of Haematology, 84, 137-143.
17. H locus. European Journal of Immunology, 23, 832-839.
18. Van Kamp, H., Fibbe, W.E., Jansen, R.P.M., Van der Keur, M., De Graaff, E., Willemze, R. & Landegent, J.E. (1992) Clonal involvement of granulocytes and monocytes, but not of T and B lymphocytes and natural killer cells in patients with myelodysplasia: analysis by X-linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene. Blood, 80, 1774-1780.
19. Van Kamp, H., Landegent, J.E., Jansen, R.P.M., Willemze, R. & Fibbe, W.E. (1991) Clonal hematopoiesis in patients with acquired aplastic anemia. Blood, 78, 3209-3214.
20. Viale, M., Merli, A. & Bacigalupo, A. (1991) Analysis at the clonal level of T-cell phenotype and functions in severe aplastic anemia patients. Blood, 78, 1268-1274.
21. Vogelstein, B., Fearon, E.R., Hamilton, S.R. Preisinger, A.C., Willard, H.F., Michelson, A.M., Riggs, A.D. & Orkin, S.H. (1987) Clonal analysis using recombinant DNA probes from the X-chromosome. Cancer Research, 47, 4806-1813.
22. Young, N. (1992) The problem of clonality in aplastic anemia: Dr Dameshek's riddle, restated. Blood, 79, 1385-1392.